Stephan Köstlbacher

🚀 Identifying new eukaryotic signature proteins in Asgard archaea has been a fun, exciting, at times overwhelming (so many protein structures) but fulfilling ride so far with @Ettema_lab at @MIB_WUR

Interested in extremophiles, circular economy, novel genomic tools and biotechnology?🦠🏞️ looking for a lab to do a postdoc? 🤓 our lab invites applicants for the following call: #JuanDeLaCierva from @AgEInves tinyurl.com/y78ueh5v. PM for more info.

📢We invite candidates strongly interested in 𝗶𝗻𝘁𝗲𝗿𝗱𝗶𝘀𝗰𝗶𝗽𝗹𝗶𝗻𝗮𝗿𝘆 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗶𝗻 𝗺𝗼𝗱𝗲𝗿𝗻 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 to apply for 𝗳𝘂𝗹𝗹𝘆-𝗳𝘂𝗻𝗱𝗲𝗱 𝗣𝗵𝗗 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀. Curious to learn more? See this 🧵 or visit imprs-marburg.mpg.de

Our study on drug-gut microbiome interactions is out! 🦠💊 @NatureMicrobiol We show that the #Parkinson's drug entacapone induces iron deficiency in microbes, leading to selective inhibition of microbial activity. Check the full story here: rdcu.be/d0ZAQ

Microbial species and intraspecies units exist and are maintained by ecological cohesiveness coupled to high homologous recombination nature.com/articles/s4146…

Genome dynamics across the evolutionary transition to endosymbiosis @CurrentBiology by @sio_stef et al from Gregory Hurst @TheLadybirdman with @acdarby, @kaylacking, Mike Brockhurst cell.com/current-biolog…

How can a symbiont be located at the center of a host cell while still being an epibiont!? Please read and be astonished about the symbiosis between Anaerameoba and sulfate-reducing bacteria! Now out in Nature Communications! rdcu.be/dZGNe (1/11)

Ein @ERC_Research Synergy Grant, der mit 9,9 Millionen Euro dotiert ist, geht an ein internationales Team – 2,5 Millionen Euro davon erhält die Mikrobiologin Katharina Kitzinger von der Uni Wien.🎉 Mehr dazu: ⤵ medienportal.univie.ac.at/media/aktuelle…

Three weeks left to apply for this exciting PhD position focusing on eukaryotic genome evolution! Come work with us at @MIB_WUR! Please RT #PhDposition #evolution @WUR 🦠🧬🧐

🚨 New preprint alert! 🚨 Our latest work on Escherichia coli and the regulation of DNA replication initiation via DnaA titration on the chromosome, led by Lorenzo Olivi. Here’s a thread summarizing our findings. 🧵👇 @WUR @Ettema_lab @HohlbeinLab et al. biorxiv.org/content/10.110…

Now online the latest work of Lorenzo Olivi, @koestlste @NicoC_MicSynBio @Ettema_lab @HohlbeinLab et al. biorxiv.org/content/10.110…

New preprint out showing exciting insights on how genome replication is controlled in E. coli, also by titration!Great work led by the amazing Lorenzo Olivi and great bioinformatics by @koestlste @MIB_WUR . And great collaborations with @HohlbeinLab Pieter-Rein ten Wolde @_amolf

New study in: doi.org/10.1080/194909… Using nanopore sequencing, we identified microbial traits linked to severe brain injury in preterm infants. Enterobacteriaceae predominance ties to poor neurodevelopment, revealing potential therapeutic targets! 🧠 #Microbiome #Brain

Great work by Lorenzo Olivi, @koestlste and other colleagues from @MIB_WUR, reporting experimental and computational evidence for titration-based replication control in E. coli!

Our findings pave the way for further studies on how chromosomal organization and DnaA dynamics contribute to the control of DNA replication. Stay tuned for more! 📚 Read the full preprint here: biorxiv.org/content/10.110… #DNAReplication #Ecoli #DnaA #Genomics #Preprint

This study provides the first experimental evidence of DnaA titration on the chromosome in E. coli. This titration helps stabilize DNA replication initiation, especially in slow-growing cells, preventing premature re-initiation events. 🧬🔒