Darrell Kotton

Our hands-on cell culture course @CReM_Boston for making lung out of iPSCs has kicked off and is running all week. Those smiles you see are from day 2: making endoderm, the first step to engineering lung epithelium! #itsthecells! #helpisontheway! @BU_Tweets @The_BMC

Miriam O'Day, A1F Senior Policy Consultant, is representing the Alpha-1 Foundation at the 2026 NORD Rare Disease Scientific Symposium in Arlington, VA. This year's theme, "Advancing Innovation in Rare Disease Research," brings together a dynamic community of researchers, clinicians, industry leaders, and advocates to spark the conversations and connections that drive science forward. @RareDiseases

Congratulations to Dr. Christine Reardon for receiving the Henry D. Chadwick Medal at MTS 2026! You are so loved by your colleagues, trainees, and patients. We thank you for your expertise in intensive care medicine, lung cancer, and neuromuscular respiratory disease.

Congrats to Dr. Andrew Wilson's Lab and MD/PhD student/first author, Carly Merritt on their new paper: "AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema" biorxiv.org/content/10.648…

Congratulations to Dr. Chris Reardon, this years Chadwick Medal awardee ⁦@MassThoracic⁩ 2026! Our once and always program director ⁦@The_BMC⁩ Pulmonary.

Great to be at the Mass Thoracic Society 2026 ⁦@MassThoracic⁩ annual meeting where MTS President Finn Hawkins is now kicking off the day!

Base editing in vivo is here! so exciting! Beam Therapeutics Announces Update on BEAM-302 for alpha-1 antitrypsin deficiency .alpha1.org/beam-therapeut…

Today, Beam announced updated safety and efficacy data from the ongoing Phase 1/2 trial of BEAM-302 in alpha-1 antitrypsin deficiency (AATD) and the selection of 60 mg as the optimal biological dose to advance into pivotal development to support potential accelerated approval.

The Kotton Lab announces our latest biorxiv posting; a collaboration with the labs of Jessie Huang @hjhjess and Will Zacharias. "The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells" biorxiv.org/content/10.648…

Such a treat to tell our story of how discovering a previously unknown mechanism that controls IPF alveolar epithelial stem cell regeneration also enhances lung resilience against viral infection.

We are back with the 4th edition of this fantastic lung meeting and what a busy day the #FusionLung26 crowd have had! Amazing talks, sharp questions, and lots of ideas to take back to the lab. We even made time for a quick snorkelling excursion along the beautiful Playa Mujeres coastline 🚤 🔬We are wrapping up this inspiring day with our first fantastic poster session and dinner!

Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis biorxiv.org/content/10.648…

The Kotton Lab is pleased to announce our latest work, just out @biorxivpreprint. Congrats to first author, Andrea Alber and all the team @CReM_Boston ! biorxiv.org/content/10.648…

#itsthecells #helpisontheway @The_BMC @BUMedicine @Northeastern

Just out @AJRCMB, our review of how axolotl salamander lung regeneration offers many hints for advancing human lung regeneration research for our patients: atsjournals.org/doi/abs/10.116… Thanks to first author, Aaron Dobie @CReM_Boston and senior author James Monaghan @monaghan_lab!

Thrilled to host Dr. Hao Zhu @CReM_Boston as this year's 10th anniversay Annual Anita Kurmann Memorial Lecturer! Inspiring science from the @Zhu_Lab in Anita's honor. #itsthecells

Saddened to hear of John Gurdon’s passing. A brilliant scientist, generous mentor, and endlessly curious. When he examined my PhD viva in 2006, he’d just come from doing experiments at his bench - at 73. He shaped so many careers, including mine: cam.ac.uk/research/news/…

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body. The Nobel Prize laureates identified the immune system’s security guards, regulatory T cells, thus laying the foundation for a new field of research. The discoveries have also led to the development of potential medical treatments that are now being evaluated in clinical trials. The hope is to be able to treat or cure autoimmune diseases, provide more effective cancer treatments and prevent serious complications after stem cell transplants. #NobelPrize

honored to join @stemcellreports editorial board. Looking forward to helping get the word out on the latest advances in stem cell and regenerative medicine research! #itsthecells!