Katie Guzzetta 🌻

Gut microbes affect #cognition during #ageing nature.com/articles/d4158… #GutMicrobiome #Aging

@Nature @drdrcox @MaayanLevyPhD We identified a pathway linking microbial and metabolic changes in the gastrointestinal tract over the lifespan, peripheral inflammation, vagus nerve dysfunction, and reduced memory formation in the hippocampus. More details here: youtu.be/eUhY6KOZvOA

🔔 Antibiotics induce profound changes to the gut microbiome. Even a single course of antibiotics has lasting effects up to 8 years later. 💊🦠 nature.com/articles/s4159…

Maternal microbiome-derived propionate regulates offspring myelination via histone lactylation academic.oup.com/brain/article-…

Plus the Spotlight from the Al Nabhani lab: When infant #microbes guide mom’s milk cell.com/trends/microbi…

Time-specific bidirectional links between the maternal #microbiome, milk composition, and infant #GutMicrobiota cell.com/cell-host-micr…

We are excited to present our new study @Nature, led by @DrDrCox and performed in collaboration with the lab of @MaayanLevyPhD, in which we explore the impact of gut-brain axis aging on cognitive decline. nature.com/articles/s4158…

Featured Article: Virome enterotype dictates inflammation Gut virome enterotypes influence intestinal inflammation w/Entero-2 predominant in Crohn’s disease & proinflammatory in mice. E2 enriched in phage that ↑B. theta sphingosine & inflammation cell.com/cell-host-micr…

Intestinal interoceptive dysfunction drives #age-associated cognitive decline. #GutMicrobiome nature.com/articles/s4158…

Preterm microbiota & sepsis: Delayed microbiome maturation in preterm infants mediates Abx-induced late-onset sepsis susceptibility. DL-endopeptidase-producing bacteria prevent murine sepsis via NOD2-immune tolerance & probiotic enhances NOD2 in infants cell.com/cell-host-micr…

New online! Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut dlvr.it/TRFmKq

Determinants of FMT success · cgMLST enables high-resolution strain tracking · Intra-species dynamics, not species, drive FMT clinical efficacy across diseases · Conserved ecological strategies govern colonization · HSIM score predicts therapeutic outcomes cell.com/cell-host-micr…

We all know fibre improves bowel function, but by how much and does it vary by fibre? Huge synthesis of 113 trials in adults with normal bowel function Insoluble & low-fermentable fibres have biggest impact Great work @Prof_NickTalley & team! ajcn.nutrition.org/article/S0002-…

Virome regulates nutrient sensing Enteric virome, dominated by bacteriophages, can autonomously activate host immune signaling to modulate intestinal metabolic responses and regulate carbohydrate digestion & absorption cell.com/cell-host-micr…

Distinct prophage infections in colorectal #cancer-associated Bacteroides fragilis #GutMicrobiome nature.com/articles/s4385…

Job alert🚀We are recruiting a Bioinformatics Scientist to help guide the lab's computational research, contribute to ongoing projects, and pursue independent research. Come join us in Basel, Switzerland! More info at: tinyurl.com/nhe4epse @ETH_en @ETH_BSSE

Spatial atlas of murine gut Image-based transcriptomics inform cell-type expression & spatial organization of receptors sensing diet-, self- & microbial-derived molecules in murine gut. Work uncovers microbiota-dependent modulation of gut structure cell.com/cell-host-micr…

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health nature.com/articles/s4157…

Early-life Microbiota Disruption-Induced Deficits in the Social Brain are Sensitive to Diet cell.com/iscience/fullt…

Beautiful study showing that with age brain tissue resident macrophages, also called microglia, drive cognitive decline through a failure to clear damaged neuronal proteins and synapses. doi.org/10.1038/s41586…