Glover Lab

🔬 New lab preprint: How does the mode of oncogene activation shape PROTAC efficacy? Led by Evelina Gudauskaite, we ask whether stabilising mutations vs transcriptional upregulation have distinct consequences for targeted protein degradation. biorxiv.org/content/10.648….

Today in @NatureGenet, we report a saturation genome editing study that systematically dissects the degron of β-Catenin: one of the most frequently mutated regions of the cancer genome. Collab with @kiddevonline and @DeryaDOzdemir, among many others rdcu.be/e1Tvk

🚨 Come join us @sheffielduni for a PhD on the evolution and development of feathers and flight! 🐣🔬 This project is supervised by @Mattowers1 @AlexGFletcher, and I'm excited to be involved as a project advisor. Please share! findaphd.com/phds/project/b…

🚨 Introducing FuChi (Fucci Chicken), the first avian cell cycle reporter line. Thank you to all those who made this paper possible. I believe it really showcases the power and beauty of the chick embryo as a developmental biology model. 🐥 🥚 🔬 biorxiv.org/content/10.110…

Phewww it was some journey getting to preprint but finally here we are! Awesome fun collaboration with *ten* @roslininstitute labs represented and wider collabs too, showing that diverse IAVs can replicate in cow udders, with biggest credit to @RuteMPinto biorxiv.org/content/10.110…

🐣Chick embryo (Gallus gallus domesticus): a window into vertebrate development. From heart and limb formation to neural crest migration and axis patterning, this model has been cracking the developmental code for over a century. Image by Vincent Pasque #ModelMonday #DevBio

The 12th Avian Model Systems Meeting is happening this fall!! tinyurl.com/2s3mynw6 We hope you can join us at the Stowers Institute @ScienceStowers, Kansas City to talk all things birds, biology and breakthroughs!! 🐣🐔🪶

Only a few days left to apply for our @BBSRCWhiteRose-funded PhD project with @ChrisToseland aiming to understand how biomechanical cues crosstalk with extrinsic signals to influence cell fate decisions during hESC/NMP differentiation. Please RT! findaphd.com/phds/project/d…

My lab is advertising just one PhD studentship this year, looking at consequences of maternally acquired viral infection for foetus with @dr_sara_c , @neilmabbott1 and @lab_glover . Please see link below for further info! eur02.safelinks.protection.outlook.com/?url=https%3A%…

@Analia_hr @xiongfz Congratulations, Ana! Well deserved.

I defended my PhD today!! 🎓🥂 So honoured to have shared this journey with the @xiongfz lab!! It's been an amazing experience

The postdoc position in my lab @FBMH_UoM is open for applications until 15th November jobs.manchester.ac.uk/Job/JobDetail?… and I am also looking for a research technician jobs.manchester.ac.uk/Job/JobDetail?…! Come and have fun with Chicken embryos and single-cell Multiomics! 🐣🧬🐣

Great story from @AnaisBailles on the role of #mechanics in initiating the remarkable #Hydra reformation from #singlecells to functional #animal. Supported by @GiuliaSerafin12 HCR, @carldmodes & @zechnerlab modeling & Heino Andreas Hydra husbandry @mpicbg @csbdresden @PoLDresden

🚨 Job alert in theory/devbio/mathbio 🚨Official applications for PhD/postdoc opportunities in the Hiscock lab are now live! Check out twhiscock.github.io for links. Deadline 10 November.

Come and join the Williams lab @OfficialUoM @FBMH_UoM @The_MRC We are using single-cell Multiomics and in vivo CRISPR approaches to understand the molecular mechanisms underlying lineage segregation from the neural plate border 🐣jobs.manchester.ac.uk/Job/JobDetail?…

#CHARGEsyndrome involves aberrant #NeuralCrest development due to mutations in CHD7. @Ruth_Y_Williams @saukaspengler &co explore enhancers & tissue-specific TFs that regulate Chd7 expression in developing chick & human neural crest @TSS_Lab #PLOSBiology plos.io/4eO4wfl

We are looking for an enthusiastic PhD candidate to study the regulation of chromatin remodellers in neural crest and their role in developmental disorders. #neuralcrest #neurocristopathies #singlecell #multiome #CRISPR @smbanka @OfficialUoM @The_MRC findaphd.com/phds/project/m…

Our study decoding gastruloid symmetry breaking is now live @NatureCellBio! rdcu.be/dVMLG Thank you to the NCB edititorial team and to our reviewers for a constructive review process which helped improve our study. A thread on updates (1/n):

Grigorii & Michel’s method for staining collagen fibres (lanevol.org/projects/FGsta…) has generated multiple award-winning images. Now, we’ve won 3rd prize in @MicroscopyToday’s Published Image category & 1st prize in their Video category!🔬🐁 @UNIGEnews @genevunige @Biologie_UNIGE

🚨 Job alert in theory/devbio🚨 Funded by an ERC Starting Grant (woohoo!!), we are recruiting theory postdocs and PhD students to study how embryonic patterns self-organize. Please RT 😊 @ERC_Research @TLM_Cambridge @the_Node @SMB_MathBiology @PhysicsofLifeUK @PoLDresden 1/🧵