Laurits Frøssing

Deligthed to see our paper out, demonstrating a universal role of mast cells in asthma - but with different localizations across asthma phenotypes. #asthma #phenotype #ahr. #mastcellsmatter jacionline.org/article/S0091-…

@doclip1 I agree that T2-low is where we lack options and assessment of Teze on strictly T2-low would be very enlightning albeit difficult to recruit to as you highlight. IMHO a key step is moving away from a definition based on the absence of T2 to the presence of something.

@lauritsfrossing Also by the same token should we use a lower cut point for FeNO to define true T2 low in more severe pts ?

Here we have an analysis of T2 biomarkers across a range of asthma severities from BREATHE cohort lnkd.in/eB2zjWSG   The main reason I am posting this is that I don’t resonate with the rather high prevalence (34%) of so called T2 low severe asthma…lnkd.in/ewvQJDuT

@doclip1 We have been cautious with the terminology in both papers ie "no biomarkers elevated" rather than "T2-low" for this exact reason.

@doclip1 I believe we agree on the prevalence of true T2-low - it is rare - and I do not believe the references Venn-diagram is fit to identify true T2-low as would lower cutoffs for both IgE and B-eos would be needed IMO.

Happy to see our research highlighted by the ERS! A key takeaway for daily practice is the need for routine airway inflammometry - not only in specialized SA clinics - as eosinophilia otherwise is overlooked in a large proportion of patients @RespBispebjerg @PluZdk @CPorsbjerg

Extremely proud to share our first study coming out of the VITAL study: "Allergen Immunotherapy Enhances Airway Epithelial Antiviral Immunity in Patients with Allergic Asthma" atsjournals.org/doi/abs/10.116… #asthma #Immunology #Immunotherapy @RespBispebjerg

Happy to see our Lancet seminar on asthma out! sciencedirect.com/science/articl…

Vi bruger tid & kræfter i @akutberedskabet på at tage os af folk, der har drukket for meget - og faktisk kan du hjælpe! Se Karl fortælle om det her, og del meget gerne videoen. #sundpol #dkpol @RegionH

Calling all translational researchers with an interest in airways immunology og strong team skills! Excellent opportunity to be part of a truly clinical translational team - in a fantastic era of targeted immune treatments - with a strong focus on impact! ofir.dk/resultat/wanti…

@CPorsbjerg #bronchiectasis #severeasthma #eosinophilia

Exiciting times ahead with studies assessing treatments targeting both inhibiting of eosinophil degranulation (LTRA) and also IL5 (mepo -> Uni of Catania @Crimillina) @RespBispebjerg @JACIGlobal @jacionline

Excited to share our recent findings highlighting airway eosinophilia - and in particular eosinophil degranulation - as a key player in severe asthma patients with bronchiectasis. jaci-global.org/article/S2772-…

Time to consider allergen immunotherapy in asthma patients with frequent infection driven flare-ups? Exciting findings from @CWhlk @RespBispebjerg #diseasemodification #preventsevereasthma #asthma #allergy #infections #exacerbations bit.ly/3SiPbaY

@katiejbaines Thank you Katie, hope everything is well with you. Time flies.

@lauritsfrossing Congratulations!

In this real life cohort of asthma patients we compare expression of biomarkers - including induced sputum - across asthma severity. openres.ersjournals.com/content/early/…

A huge thanks to all coauthors and collaborators for their huge contributions. @RespBispebjerg @CPorsbjerg @PluZdk @ERSpublications

We find T2 inflammation to be more prevalent in SA and that biomarker expression relating to more than one pathway to be a particular trait of SA. Our findings also highlight the need for clinically feasible airway inflammometry as 22% of patients had airway eos without blood eos

In patients with severe asthma, former smoking history is associated with eosinophilic airway inflammation and activation, relative insensitivity to steroids, and airway autoimmunity. Study in @ERSpublications. #pulmonology @lauritsfrossing @DrMMukherjee fal.cn/3nJlV