Lisa Champion retweetledi
Lisa Champion
1.5K posts

Lisa Champion
@lmareechampion
Interested in anything to do with diabetes, especially T1D.
Katılım Ocak 2022
3.5K Takip Edilen379 Takipçiler
Lisa Champion retweetledi

Dr. Bernstein was the first person to believe that diabetics were truly entitled to the same blood sugars as non-diabetics. An idea that industry *literally* laughed at when Dr. Bernstein brought this idea up at conferences, while his methods to obtain normoglycemia were openly mocked and rejected by authorities in the medical community.
This clip is from a great movie produced by @LetMeBe83 called The Diabetes Solution.
youtu.be/9H163_uHfSw?si…
Definitely worth a watch 👍👍

YouTube
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Lisa Champion retweetledi

@Hoonyusi If it is cold where you are - an electric throw rug.
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Lisa Champion retweetledi
Lisa Champion retweetledi
Lisa Champion retweetledi

Type 1 diabetes was cured in mice – permanently.
In a groundbreaking study, scientists successfully halted type 1 diabetes in mice by co-transplanting blood-forming stem cells and insulin-producing islet cells from a donor. This created a mixed (chimeric) immune system — part donor, part recipient — that tolerated the new islet cells and prevented further autoimmune attacks on the pancreas.
Type 1 diabetes occurs when the immune system mistakenly destroys the body’s own insulin-producing beta cells in the pancreatic islets. The new approach essentially “resets” this faulty immune response.
- Mice first received low-dose radiation and targeted antibodies to mildly suppress (but not wipe out) their immune system.
- They were then given donor hematopoietic stem cells (to rebuild a tolerant immune system) and healthy donor pancreatic islets (to restore insulin production).
- A short course of an existing immunosuppressive drug was added to bridge the process.
The results were striking: no rejection of the transplanted cells, no graft-versus-host disease, and complete prevention or reversal of diabetes. In one group, all 19 treated mice remained diabetes-free; in another, all 9 mice with established diabetes were fully cured.
Importantly, nearly every component of this protocol — the antibodies, low-dose radiation, and immunosuppressive drugs — is already approved and routinely used in human medicine. This dramatically shortens the path to clinical trials in people.
Challenges remain, particularly the limited supply of human islet cells and the need for donor-recipient matching. However, researchers are actively developing lab-grown islets and techniques to generate larger quantities of compatible tissue.
If proven safe and effective in humans, this strategy could not only cure type 1 diabetes but also revolutionize treatment for other autoimmune conditions (such as lupus and rheumatoid arthritis) and improve outcomes in organ transplantation.
["Curing autoimmune diabetes in mice with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning." Journal of Clinical Investigation, 2025]

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Lisa Champion retweetledi
Lisa Champion retweetledi

This was the first ever beta cell transplant for type 1 diabetes... with no immunosuppression
The cells were edited to avoid immune attack and – to prove the concept – they were transplanted into the patient's forearm, where they started making insulin!

Samuel Hume@DrSamuelBHume
What's the coolest science paper of 2025 so far?
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Lisa Champion retweetledi
Lisa Champion retweetledi
Lisa Champion retweetledi
Lisa Champion retweetledi
Lisa Champion retweetledi

It's only a pipette if it comes from the Pipette region of France otherwise it's a sparkling sucky tube
Parmita Mishra@parmita
Is it pipet or pipette
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Lisa Champion retweetledi
Lisa Champion retweetledi

“Oh my god… I have no words.”
Listen to the emotional moment this year’s laureate Maria Corina Machado finds out she has been awarded the Nobel Peace Prize.
Kristian Berg Harpviken, Director of the Norwegian Nobel Institute, shared the news with her directly before it was announced to the world.
#NobelPrize #NobelPeacePrize
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Lisa Champion retweetledi

The treatment of type 1 diabetes is entering a revolutionary era.
Via @TheLancet
thelancet.com/journals/lance…
Production and transplantation of β cells derived from embryonic or induced pluripotent stem cells 👇

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Lisa Champion retweetledi

🚨The @SoleimanpourLab is hiring!!! 🚨
If you or someone you know is looking for a post-doctoral position and interested in studying mitochondria and diabetes, please get in touch (or RT)!

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