malhar

50 posts

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malhar

malhar

@malhar317

cto @origin_bio, @ycombinator, prev: uiuc cs @siebelschool

San Francisco Katılım Temmuz 2023
924 Takip Edilen1.1K Takipçiler
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malhar
malhar@malhar317·
Cell and gene therapies have the potential to offer a much higher quality of life to patients. Getting transcriptional control right is going to unlock a whole new class of them. Happy to share a small preview into Axis’ ability to design novel regulatory DNA sequences. It’s so obvious that evolution has only explored a drop in the whole ocean. Now finally with AI can we start to take a deep dive.
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Y Combinator@ycombinator

Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…

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Garry Tan
Garry Tan@garrytan·
AI x Bio teams like Origin have coding agents, scaling laws, and a wave of big biotech deals all at their backs. This is barely touched territory. Crazy what this small team can do now.
Yash Rathod@YashRathod_75

Today, we're excited to release 10,000 fully AI-designed enhancer sequences for the research community. Axis was prompted to design sequences with targeted activity in one of three widely used cell-lines. AI allows us to explore a vast design space, going beyond the natural genome.

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Yash Rathod
Yash Rathod@YashRathod_75·
Today, we're excited to release 10,000 fully AI-designed enhancer sequences for the research community. Axis was prompted to design sequences with targeted activity in one of three widely used cell-lines. AI allows us to explore a vast design space, going beyond the natural genome.
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Viraj Doshi
Viraj Doshi@viraj9451·
Muon can accelerate LLM training, but does that benefit transfer to regulatory DNA sequence modeling with its different data distribution? 🧬 Our results show that Muon with independent weight decay (MuonW) hits our validation perplexity target in ~37% fewer FLOPs than the best Adam configuration.
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Y Combinator
Y Combinator@ycombinator·
.@PirisLabs delivers low-latency, low-cost AI inference by eliminating the memory wall using full-stack optical interconnects and a purpose-built software stack. Congrats on the launch Ali & Keyvan! ycombinator.com/launches/PQd-p…
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Y Combinator
Y Combinator@ycombinator·
.@dittobio discovers drugs for autoimmune diseases by harnessing parasite biology. Viruses, ticks, and worms have experimented over millions of years to create proteins that control the human immune system. Ditto Bio is using AI to identify these natural, drug-like proteins and engineer them into next-generation autoimmune therapies. Congrats on the launch @AdairLBorges, @Mezarque, and @emilycpierce! ycombinator.com/launches/PNb-d…
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malhar
malhar@malhar317·
@agupta Thanks Ankit! It’s awesome learning from you :)
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Ankit Gupta
Ankit Gupta@agupta·
This is a very special team. True pair of polymaths at the intersection of computer science and biology. Their first model beat Deepmind's AlphaGenome on benchmarks and they're now using that to design cell and gene therapies. Congrats on the launch!
Y Combinator@ycombinator

Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…

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Hunter
Hunter@hunterharloff·
Transformers extending to bio is one of those things that just feels obvious - what is the molecular machinery of life, if not a language? Yash & Malhar are the real deal. Wicked sharp. Excited to support them as they shred legacy approaches.
Y Combinator@ycombinator

Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…

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Yash Rathod
Yash Rathod@YashRathod_75·
We're still in the early days of durable and long lasting drugs based on transcriptional control - similar to where mRNA medicines were many years ago! With AI designed regulatory DNA and millions of sequences we're lab testing, we aim to precisely program gene expression @origin_bio
Y Combinator@ycombinator

Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…

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Sandro Herbig
Sandro Herbig@sandroherbig·
Excited to cofound @merge. Our goal is to maximize human agency by building very high bandwidth brain computer interfaces that enable us to seamlessly interface with AI. We hope to build products that unlimit our ability to imagine and create. If this sounds exciting – Join us!
Merge Labs@merge

Hello world! 👋 We are Merge Labs – a research lab with the long-term mission of bridging biological and artificial intelligence to maximize human ability, agency and experience. Read more about it from our founding team + join us: merge.io

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Liam Bai
Liam Bai@liambai21·
Keytruda is one of the most important cancer drugs in history, saving countless lives and generating $30B per year in sales. But how does it work? I break down the molecular mechanisms in this blog post, with interactive visualizations 👇
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Keşfet

@trainburt @bobbyzhong333 @zerodaykurt @narendramodi @origin_bio @PirisLabs @dittobio @AdairLBorges