Mass Spec Pro

@DirtDiver1983 @TeamViewer_help Definitely. Myself and many colleagues can't connect currently.

@TeamViewer_help Unable to connect to TV servers when logging in. Something going on?

While I have enjoyed Twitter for many years, I think I'm going to give BlueSky a try. Just can't get behind Elon's recent activities.

We are sad to share news of Jean Futrell's passing. He was a GIANT of mass spec and a MIGHTY advocate & supporter of @asmsnews. Our thoughts are with Jean's family, friends, and colleagues. Learn more about Jean: asms.org/publications/j… asms.org/about/history/… #TeamMassSpec

[ASAP] Simulation of Space Charge Effects in Fourier Transform Quadrupole Ion Traps (FT-QITs) dx.doi.org/10.1021/jasms.…

[ASAP] Hybrid Quadrupole Mass Filter–Radial Ejection Linear Ion Trap and Intelligent Data Acquisition Enable Highly Multiplex Targeted Proteomics dx.doi.org/10.1021/acs.jp…

#TeamMassSpec is pretty spicy on here the last few days.

@Popher For the icr?

@chrashwood Agreed. Marketing teams of all companies take liberties with terminology, specs, etc. It's frustrating.

@chrashwood If i understand the "Zeno" process correctly, there is no way it could run in that mode at 600+ Hz

@seejbrown @chrashwood @MobilionSystems Yeah...400ms of ions with any kind of sample load on column is a gigantic number of charges

@chrashwood @MobilionSystems Challenging to interpret this paper. Not sure about the duty cycle claims - can they trap 400 ms of ions without space charge? Can they focus those ions? How does this work w/complex mix? I really want to know how midia-PASEF Compares? Best of both worlds?

@chrashwood @MobilionSystems 100% seems... very unlikely

@chrashwood @MobilionSystems Haven't read it yet. Do they take the tof efficiency into account? Most tofs are horribly inefficient.

@Popher What's wrong with the tribrid?

Comet's open-source search engine has been a boon for our proteomics methods developments (like real-time search). Over the last two-years we became curious whether Comet's search speeds could be improved to keep pace with modern instruments and large sample cohorts.

@Popher It can definitely be useful in combination with msn for unequivocally stringing together fragmentation paths (e.g. A+ -> B+ -> C+), especially when combined with hram. It’s one of the (many) things I love about tribrids.

@Popher I think the main practical difference is that you don’t get much sequential fragmentation with “cid” in traps on thermo instruments, because the excitation waveform is only exciting the precursor mz.

@Popher I’m assuming it’s regulated the same as San Jose instruments, and the ‘units’ is just psi. If it can’t get up to a number that it used to before, there’s probably a leak (e.g. if the source hosting isn’t sealed to the instrument well).