Matt Pelo

971 posts

Matt Pelo

Matt Pelo

@mattpelo

Founder & CEO @foregenomics, https://t.co/nBGeNlaZSJ. Genetic health screening designed for children. Exited founder and experienced builder.

San Diego, CA Katılım Haziran 2007
711 Takip Edilen410 Takipçiler
Matt Pelo
Matt Pelo@mattpelo·
@maddiehfaulkner I don't know where folks lost sight of fundamentals like return on equity but have to imagine this turns at some point and operating metrics are valued again.
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Madison Faulkner
Madison Faulkner@maddiehfaulkner·
I am finding myself way more impressed and interested in the companies who have raised less and stayed efficient while growing rapidly than those that have blown up fundraising processes
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Matt Pelo
Matt Pelo@mattpelo·
@arian_ghashghai We did that and it has worked well. There hasn't been a good mechanism to get early checks in without lead/priced round so having escalating SAFE valuations helps create urgency.
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arian ghashghai
arian ghashghai@arian_ghashghai·
i've seen a few rounds now where the founders reject a priced round (i.e. every new investor pays the same entry price) to raise on SAFEs with rapidly ascending valuation caps. they end up securing more capital with less (future) dilution than if they had taken the priced round: > early priced rounds being put on the back burner. more net dilution (sometimes) + more admin headache (sucks for VC markups!) > fundraising is a live auction atm > being an auction, priced round term sheets box in how much a company can raise (and at what cost), limiting how much a company can leverage its "hotness" factor to raise cheap capital feels like something needs to be fixed here: > priced rounds are absurdly archaic (administratively) and much too slow/painful vs SAFEs (I'm always bemused it takes a couple of months to go from signed TS to closed round i.e. wired capital). As a pre-seed investor, I'm also not unhappy about founders raising their seed rounds on SAFEs as it kicks the can down the road on my dilution (i.e. potentially better for DPI) = very little incentive to do priced rounds from both sides > schizophrenic VC behavior that disregards the entry price (i.e. paying 2x vs what the VC before me paid yesterday) under the pretense that "wHaT IF its THe nexT FaCeBoOK" is financially irresponsible and unsustainable as fudiciaries of LP capital
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Matt Pelo
Matt Pelo@mattpelo·
@JamesBorow Always looking for help at Fore. We have a children’s health product to detect hundreds of genetic conditions early in life. Already helping kids, trying to spread awareness.
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Jamesborow
Jamesborow@JamesBorow·
I have a group of friends who are kind of legends in the adtech space, don't want to join a big co and want to start something new. What should they start? If your idea ends up being picked ill make them make you an advisor.
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Ollie Forsyth
Ollie Forsyth@ollieforsyth·
Made 3x angel investments over the past week: - Former Operators - Repeat Founders - YC Founders If you are building something enduring, cool, exciting - post your projects below and let's help you get noticed 🚀
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Naval
Naval@naval·
AI is going to drain a lot of moats.
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Matt Pelo
Matt Pelo@mattpelo·
@boardyai Hi @boardyai you made another intro for me today. It was great. Thanks. This whole thing is weird to me but seems to work. Please avoid the start up scammers, need feedback loop if people are helpful or not. Too many leeches in ecosystem.
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Boardy
Boardy@boardyai·
The next billion dollar company can't get a meeting rn. Venture capital runs on warm intros.
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Matt Pelo
Matt Pelo@mattpelo·
@TSpeth5 @TripleNetTyler Sunrise at 7am this morning (San Diego), started getting light around 6am, could do anything outside by 6:30. I have to imagine it's 1000:1 the people that benefit from the extra hour at night vs. 5-5:30am first sunlight.
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Speth
Speth@TSpeth5·
@mattpelo @TripleNetTyler It has to be broad daylight for there to be enough light in my bathroom to do anything without the light on so I’m not sure why people are so butthurt about having to have lights on in the morning.
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Matt Pelo
Matt Pelo@mattpelo·
@alexiskold Ha - this makes no sense. There has never been a right way to do this and so many variables (people, Zoom, time zones, presenting, etc) I’ve been pushing more for ad hoc calls like we used to have pre Zoom and those work really well.
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Alex Iskold | 2048.vc
Alex Iskold | 2048.vc@alexiskold·
I see many founders and people in the industry get scheduling meetings wrong. Here is the simplest, most respectful way to do it. But first, how not to do it. If you say -- let me know when works for you -- thats not optimal because then you are asking me to do work. If you say -- here is my calendar -- this may also not be ideal, or perceived as agressive. So whats the solve? You say: Please send me your calendar link or let me know what times work for you. Alternatively, if works better for you, I am available at these specific times: Give two small time blocks in AM and two in PM on two separate days. You can do this manually or via Vimcal or your favorite calendar. This is fast. comprehensive, respectful and always works.
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Matt Pelo
Matt Pelo@mattpelo·
@iam_preethi Yep. Watching this it’s obvious baby’s body needs/wants the cord blood. Glad we had a doula to help navigate system.
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Preethi Kasireddy
Preethi Kasireddy@iam_preethi·
Since some of you are mentioning delayed cord clamping in the replies, here you go. All three of my babies had delayed cord clamping as well. We waited until the cord stopped pulsing on its own. Most people don’t realize that when a baby is born, up to a third of their blood is still in the placenta. That blood belongs to the baby. It’s packed with red blood cells, stem cells, and iron. Clamping the cord immediately cuts that transfer short. Delayed cord clamping lets the placenta finish its job. And the research backs this up. Babies have higher hemoglobin levels, better iron stores for up to six months, improved brain myelination at 12 months, and for boys, better motor and social development at four years old. My midwives didn’t rush this. They waited until the cord went white and limp and stopped pulsing entirely. This used to be normal. For centuries nobody rushed this. Then hospitals started clamping immediately because it was faster. Your baby spent nine months connected to that cord. Give it a few more minutes to do what it was designed to do.
Preethi Kasireddy@iam_preethi

My midwives never washed the white coating off my babies after birth. They told me to leave it on as long as I could. With all three kids, I delayed the first bath for about a week. That coating is called vernix. It starts forming halfway through pregnancy. It's antimicrobial, moisturizes the baby's skin, and has proteins that protect against infection. Babies born earlier tend to have more of it. Babies born later have less. The WHO recommends leaving it on for at least 6 hours, ideally 24. Yet many hospitals still bathe babies within hours of birth. Your baby spent months building that coating. Maybe don't wash it off in the first hour.

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Matt Pelo
Matt Pelo@mattpelo·
This is such a great point. I have a lot of investor conversations that are frustrated by lack of liquidity from prior private investments. Many are marked up big on paper and they’d love to reinvest those funds. Many want companies now structured for quick ROI to avoid trapped capital.
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Michael P Gibson
Michael P Gibson@William_Blake·
Founders who care about the next generation of founders go public. Founders who care about America and want to share wealth gains with all Americans instead of the privileged few go public. Taking money off the table with sweetheart Series Bs weakens a founder’s hunger and will power. Raising Series F and G from sovereign wealth funds, college endowments, and so on enriches the globo professional class and not Main St retail investors. The earnings from IPOs to angels andVCs gets recycled into the next generation and makes their business model viable. Founders keeping companies private and taking money off the table is a defection in an iterated game that will stop.
Michael P Gibson tweet media
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Matt Pelo
Matt Pelo@mattpelo·
@ekernf01 @OmicsOmicsBlog Start talking to Chat. I advise a few biotechs and AI has helped technical founders learn the business side quickly.
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Eric Kernfeld
Eric Kernfeld@ekernf01·
I have a friend in Montreal interested in starting a biotech with cool science and working products from their Ph.D., but their business plan is at the absolute most primordial early stages. Is there any place they could go to help understand how people found companies? Plz DM.
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Matt Pelo
Matt Pelo@mattpelo·
@CroftVale @staysaasy This was my question - are these people that refer to AI slop using AI correctly and iterating on it to help with content or just simple input->output. If used correctly can be a lot better than what you can create without it.
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Croft Vale
Croft Vale@CroftVale·
@staysaasy the real test isn't whether they used AI — it's whether they edited the output. a well-edited AI doc is great work. an unedited one is just forwarding your homework to the teacher with the tutor's handwriting still on it
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staysaasy
staysaasy@staysaasy·
We need to settle on the response when someone dumps an AI-generated doc on your plate. I'm debating whether to treat slop-dropping like a poor work product (provide thoughtful feedback privately), or like an outward display of disrespect (provide aggressive feedback publicly)
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Matt Pelo
Matt Pelo@mattpelo·
@NickRaffaele53 @LinksGems It’s tough to beat Coronado. I wish there was a better system to get on (they got busted a while ago for insider tee times but not sure it’s much better) and too many holes at the same 380-420 length so have a lot of the same approach shots.
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Nick Raffaele
Nick Raffaele@NickRaffaele53·
@LinksGems Charleston Muni is up there, but Coronado Golf Course has to be a close second?
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LinksGems
LinksGems@LinksGems·
What do you guys think is the best “true” muni out there? A “true” muni, according to my entirely made up definition, must be both owned by the municipality and offer locals greens fees under $50 during the week. Until someone beats it, the terrific Charleston Muni has my vote.
LinksGems tweet mediaLinksGems tweet mediaLinksGems tweet mediaLinksGems tweet media
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Matt Pelo
Matt Pelo@mattpelo·
@amarifields_ @kryptoJinJin I don’t think financials should be needed for an investor but should have a high level financial model and should be tracking expenses and have P&L and Balance Sheet, even if very basic.
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Amari Fields
Amari Fields@amarifields_·
currently raising a $500k pre seed round. some investors ask for financials, others say you do not need them at this stage. early stage fundraising feels like a different rulebook every conversation. founders who raised… what was the real deciding factor for your investors?
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Amari Fields
Amari Fields@amarifields_·
@kryptoJinJin without financials, how do you create that credibility investors seek? what is the difference between a founder that gets funded, and one who doesn’t
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Mode One Bravo
Mode One Bravo@BalzHari·
@mattpelo @ObviousRises 100% believe this happens. Had an anesthesiologists group code an epidural for my wife that says the anesthesiologists is sitting next to her for the 13 hrs she had the epidural. They wanted $13k from us.
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MR. OBVIOUS
MR. OBVIOUS@ObviousRises·
This is the best kept secret in the healthcare industry, in the US you can literally just not pay bills, because of the way the law works, they cannot legally garnish the money from you, in other words if you ignore the bills the debt eventually expires, its really that easy.
TheWealthCoach@indexnforgetit

Guy I work with told me he just doesn't pay medical bills Doctors appointments, surgeries, urgent care... none of it. Says he hasn't paid a single medical bill in 8+ years Says it doesn't count against credit because medical is usually deleted from reports when applying for loans Drives 2 brand new vehicles, has a big house, lives in good area... just doesn't pay any medical bills

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Matt Pelo
Matt Pelo@mattpelo·
@cullenroche Thank you. I read this yesterday and am glad someone corrected them. I loved the liability without mentioning the asset eg accounting 101 then framing as a scam.
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Cullen Roche
Cullen Roche@cullenroche·
This is a compelling story, in part because it paints banking as a scam. It's also completely wrong and based on myths that have been debunked a million times. First, the 10% reserve ratio is a relic. Today, reserve requirements in the USA are 0%, yet banks didn't magically start making infinite loans. Why? Because solvent banks are capital constrained, not reserve constrained. This is where the original story is most misleading. When a bank receives a $10k deposit (a liability), the sending bank also sends $10k of reserves (an asset). The recipient bank’s Equity (assets minus liabilities) is unchanged. Their lending capacity hasn't improved because their Capital Adequacy Ratio hasn't moved an inch. They don't suddenly have the regulatory room to add $9k of risky new loans to their balance sheet just because they have more cash in the vault. A bank's capacity to lend is actually contingent on its profitability. If these new deposits are less expensive than their previous funding sources, the bank’s Net Interest Margin improves. Those profits eventually flow into Retained Earnings, which increases their capital. That is what actually creates the capacity to lend more. This isn't a scam; it's capitalism. Well-managed, profitable banks grow their capital base, which allows them to safely expand their lending to the economy. The multiplier story is popular because it's simple and cynical. But if you want to understand how the plumbing actually works, follow the capital, not the reserves. 👍
The Wolf Of All Streets@scottmelker

A man deposits $10,000 in a bank. The bank thanks him and records the deposit on its balance sheet. But not where you might expect. For the bank, that $10,000 is actually a liability – because technically it belongs to the customer and might have to be returned. So the bank does what banks do. It lends $9,000 of that money to someone buying a car. Now something interesting happens. The $9,000 loan appears on the bank’s books as an asset – because someone now owes the bank money. So the same $10,000 is doing two jobs at once. The depositor believes he has $10,000 safely in the bank. The borrower now has $9,000 to spend. That $9,000 gets deposited somewhere else. The next bank lends $8,100. That gets deposited again. Then $7,290 gets lent out. Soon the original $10,000 has quietly turned into tens of thousands of dollars of loans scattered across the economy. Everyone believes they have money. Depositors see balances in their accounts. Borrowers have the money they spent. Banks show healthy assets on their balance sheets because people owe them money. And here’s the best part. Banks charge interest on all those loans – maybe 7%. But the depositor who supplied the original money might earn only 0.5% on their savings account. So banks collect interest on money that mostly wasn’t theirs to begin with – and keep the difference. The system works beautifully. As long as nobody asks for the money back at the same time.

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Matt Pelo
Matt Pelo@mattpelo·
@BoringBiz_ I’ve hired PwC (audit & consulting) before. The analyst (they usually give them at least associate title) sits in corner and takes notes. The Manager runs meetings and send notes, the Director or MD does all the talking.
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Boring_Business
Boring_Business@BoringBiz_·
Jokes aside, what does an AI analyst at PwC actually do?
Boring_Business tweet media
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