mcguiganlab

Special thank you @ElisaDarcangelo for leading this project to the end!

Thank you to all authors involved - this story is a testament to all your perseverance and passion for the work we do. @nila_cwu @mcguiganlab @LabMcgaha @laillesuhnrese1 @PrinosTakis @CherylArrowsmi1 @tinyglue @craigsimmons11 @alisonmcguigan

CAF density is correlated with poor prognosis in multiple cancers. Where activated CAFs and tumor cells mix, CAFs remodel ECM and facilitate tumor cell invasion. We asked can we perturb this interaction to reduce tumor cell spread by modulating CAF activation state?

🔥NEW PAPER ALERT🔥: our study on perturbing CAF activation to modulate tumor invasion is out in @Biomaterials. If you like bioengineering, targeted screening and cell phenotype perturbations, this story is for you! 👀 (doi.org/10.1016/j.biom…

Preprint alert ✨#Fibroblast content is an indicator of poor prognosis in #cancer. But how does CAF content increase beyond recruitment? Check out our study on the link between CAF hyper-proliferation, phenotypic state and tumor cell invasion ✨

Many thanks to our funders @MbD_UofT #GrandQuestions @NSERC_CRSNG @CIHR_IRSC and support from @CRAFT_mfluidics @UHN_Research @OICR_news. And our sweet home Wallberg Memorial Building @researchuoft @bme_uoft @ChemEng_UofT @uoftengineering @BioZoneUT

This work is not possible without the support from all the brilliant co-authors and collaborations with the Jackson Lab and Nitz Lab: @c_RuonanCao, @thenancyli, @SimonLatour3, @JoseLCadavid, Cassidy Tan, Ari Forman, @hartjackson, @NitzUofT, and our supervisor @alisonmcguigan.

Check out our new paper with Jackson Lab @hartjackson where we automate manufacturing of arrays of 100s of #organoid tissues and perform high-dimensional analysis of single cells. #CyTOF @Opentrons 🔗 doi.org/10.1002/adhm.2…