Mike Doherty

@hoffmann6383 @flaskworks Thank you, and she's responding generally well to soc. I like to think that NWBO will assume a positive impact from Flaskworks when negotiating pricing with NICE. So I keep fingers crossed for when (if?) recurrence requires another set of decisions. F**K cancer. 😀

Sorry to hear about your wife. Yeah, NICE is the next wildcard after the approval decision. I'm hopeful that reimbursement is provided, especially after a cost reduction when Flaskworks comes online. I'm going way out on a limb here - I've been frustrated with where NWBO seems to be at with NICE, but I think NWBO might be trying to time NICE with Flaskworks approval to address the cost issues you bring up.

➡️A Speculative DCVax-L Approval Timeline⬅️ Last week we saw what is likely $NWBO's DCVax-L showing up in the CHM meeting minutes for June 27/28, 2024: x.com/hoffmann6383/s… Does this offer any clue as to where we are at in the approval process? For this, lets compare $NWBO's DCVax-L to another medicine that appeared in the CHM meeting minutes. Note, this is no guarantee DCVax-L will follow the same timeline. Further, I'm speculating that this is the same medicine being discussed as the CHM meeting minutes don't name the specific medicines. Without further ado, lets look at the timeline for an Alzheimer's medicine. ✅April 25/26 CHM Meeting Minutes app.box.com/s/jv487awvqzzs… "LICENSING NEW DRUGS (not previously licensed in the United Kingdom) The Commission considered and advised on: a medicine used in adults to treat the early stages of Alzheimer’s disease." ✅May 30/31 CHM Meeting Minutes app.box.com/s/jv487awvqzzs… "PRE–HEARING (The Commission considers the company’s written data a month before the potential oral hearing and decides whether or not the data have resolved the questions put to the company) The Commission considered the company’s response to questions regarding • a medicine used in adults to treat the early stages of Alzheimer’s disease." ✅June 27/28 CHM Meeting Minutes app.box.com/s/jv487awvqzzs… "PAPERS/ OTHER ITEMS The Commission considered the risk management plan of an application for the treatment of early Alzheimer’s disease." ✅July 25/26 CHM Meeting Minutes app.box.com/s/jv487awvqzzs… "HEARING (The Commission considers the company’s written data and oral representations and decides whether or not the data have resolved the questions put to the company. The Commission then advises the licensing authority) The Commission heard and considered a company’s presentation on an application for a medicine for the treatment in adults to slow the progression of mild cognitive impairment and mild dementia due to Alzheimer’s disease." ✅October 23 Approval gov.uk/government/new… "As for any new medicine, this decision was made with expert scientific advice on the benefit risk of donanemab from the Commission on Human Medicines (CHM), the government’s independent advisory body." ✅Thoughts✅ For Donanemab we see the initial CHM meeting on April 25/26 and the approval happening October 23. This is 181 days. For $NWBO's DCVax-L we saw the initial CHM meeting on June 27/28. If we add 181 days to June 27/28 we come to December 25, 2024. December 25, 2024 falls roughly in line if we look at $NWBO's DCVax-L application and apply the average approval times: x.com/hoffmann6383/s… In short, I think we are coming up on approval decision time!

@hoffmann6383 @flaskworks sufferers that may have benefited. Sadly, given that dcvax-l treatment costs £100,000s I fear it very unlikely that NICE will approve for NHS use and all that will happen is that those with sufficient resources will access the treatment, which they can do now anyway.

@hoffmann6383 @flaskworks ...and general prescription and use. For example, Donanenab was approved for marketing but was not approved by NICE for use as standard NHS care. NICE concluded that the cost of providing Donanemab outweighed the benefits that may have been delivered to the 70,000 .......

@VictoriaCoren Is Only Connect on tonight?

Johannes and Annabel symbolise something really beautiful. I hope they win. I don’t think they will, but I hope they do. ❤️ #Strictly

@jeffkeencharity Enjoying the commentary, chaps. You're doing a great job. Enjoy your evening 👍👍👍

Please excuse us as we go quite for a few hours due to Admin Commitments this evening. We’ll be back tonight and tomorrow to update you on all the latest in our competitions and how it turned out that way. #JKCharity #TheOpen

@SkySportsGolf Regarding the comment by @AndrewColtart during his Open commentary that if pros take 6 hours for a round, how long would amateurs take? Cheeky blighter. I'm a 24 handicapper and a 3 ball normally takes 3 1/2 hours at my 6,600 yd course. Imo pros take far too long.

@anydaynowJP @edgarwright So delightful !!! I worked as a Supporting Artist (Extra) that night and loved seeing the crowds of onlookers across the street.

@edgarwright I am a Japanese woman in Japan who has just seen #LastNightInSoho and got gobsmacked. I was in London in July 2019 with my son and we came across a filming location. We wondered what movie it was. Then I saw this scene on the screen today! OMG‼️😍 #AnyaTaylorJoy

@sueperkins Currently watching the recording of your first hosting. Thank you for doing a brilliant job, really enjoying it 👍👍👍

Sad I'll no longer be able to play my favourite game, but both delighted and honoured to be the new host of it. #justaminute

Unfortunately, @WindleshamGolf has decided to apply very limited discretion and returned to use of rakes, flag stick removal, discretion for staff and club members to wear face coverings indoors. Would be useful to see a copy of their risk assessment.

Just to correct the tweet from @WindleshamAGR regarding the use of rakes, @EnglandGolf have NOT decided that clubs MUST reinstate the use of rakes. EGU's updated Play Safe guidance states that clubs MAY largely return to pre-pandemic mode of operation. Clubs have discretion.

@RealDMitchell @UnbelieveTruth It's a great show. I was looking forward to watching the recording this evening but the dopes who manage the production (Lost in TV) over-allocate tickets. This means that some, like my wife and I, travel over 2 hours to be told the venue is full and are sent on our merry way.

More tickets for @UnbelieveTruth recordings are available! I've been asked to point out that some of them clash with football matches.

@UnbelieveTruth Be aware of the process, though: book your free tickets, download the tickets, travel half way across the country to get to the theatre, turn homeward bound again because they've over-allocate available seating.

Booking is now open for our first summer recording date. Details of how to book your free tickets here: bit.ly/3cnJnud.

@tvaudience @UnbelieveTruth @BBCRadio4 @ShawTheatreLdn @RealDMitchell Absolute shambolic organisation by Lost in TV. After travelling 2 hours to watch this evening's (6th July) recording and joining the queue I was told the venue was full. Amateurs.

Free @BBCRadio4 comedy tickets! All dates now released for The Unbelievable Truth recording at @ShawTheatreLdn - on 22/29 June & 6 July - hosted by @RealDMitchell. Booking now: bit.ly/3cnJnud

@FilmUpdatesBU That's just wrong. A great series.

Michaela Coel and 'I May Destroy You' were completely shut out from #GoldenGlobes nominations.

@marcus_robbins @WPAHealth My old mate Gavin works for them. Keeps saying the same. I suppose I ought to believe him now.

It may just be me and my family (though I doubt it) but I genuinely believe @WPAHealth may have the best customer service I have ever dealt with. Professional, courteous and helpful. The really go all out to put us first. Thank you for all that you do.

@ssencommunity Just wanted to complement one of the SSEN staff members I was in touch with during a power outage this evening. His name is Bradley. Bradley was informative, responsive and polite. Good job.

@irishlondoner @KTTunstall @AliceWasWearing @jetfury I know it well, cousin. Love thee CD. Just haven't yet bought the album.

@mdoh21 @KTTunstall @AliceWasWearing @jetfury You should it’s a very good album

@KTTunstall @AliceWasWearing @jetfury I like this so much I might even buy "Eye to the Telescope".

@AliceWasWearing @jetfury Well I did that a while back and it was the most viral tweet I’ve ever tweeted and they didn’t suspend me. Sexists. #justiceformencallingothermencunts

@charlottealiced @AliceWasWearing @porridgeradio Also @PillowQueeens and @genntheband.

@charlottealiced @AliceWasWearing So many brilliant suggestions. Not sure I saw @porridgeradio - definitely worth adding to the list

please RT this and tag your favourite women in the music scene in the replies. I’ll be contacting every one of them with my plan during the next few days ⬇️