Bob the Grumpy Med Chemist
2K posts
@med_chemist
Jaded. Let me know when one of you figures out how the human body works.
I want Nelly’s swing.
Have seen this a couple of times recently: If you are reporting the results of a kinase panel in a paper, please make sure to include not only the concentration of compound used, but also the concentrations of ATP used in said panel.
Glad there is room for papers like this to be published. pubs.acs.org/doi/10.1021/ac… I hope there will be some follow up on the original ACS Med. Chem. Lett. paper on the supposed probe. Some other references on metal impurities linked below, if useful.
What if there was an antibiotic that doesn't disrupt the gut microbiome? There is now. A discovery published @Nature today nature.com/articles/s4158… @PaulHergie and colleagues @UofIllinois @justsaysinmice
🧵PSA: we need to chat about pharmacokinetics & pubs. If you plan to publish in vivo PD/efficacy studies, the minimum credible accompanying PK package is an IV leg + an IP/PO leg if that's your eventual route. In the same species, preferably at the planned efficacy dose. 1/
🧵PSA: we need to chat about pharmacokinetics & pubs. If you plan to publish in vivo PD/efficacy studies, the minimum credible accompanying PK package is an IV leg + an IP/PO leg if that's your eventual route. In the same species, preferably at the planned efficacy dose. 1/
I propose a solution to 2 problems: - Lack of novel antibiotics - Abundance of terrible in vivo efficacy studies Solution: If you publish a bad efficacy study, you must instead work on antibiotics development, where output of animal model is much clearer... paws up / paws down
