@WalentekLab @SGRodriques @JocelynnPearl @EdisonSci Anecdotally: not at all. These tools have only been net-useful for ~6 months. Not long enough for organizations to adapt.
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Greg Medlock
225 posts
Greg Medlock
@MedlockGreg
Sr Director R&D @vedantabio. Interested in restoring and controlling the human microbiome.
Cambridge, MA Katılım Mayıs 2023
552 Takip Edilen307 Takipçiler
@MedlockGreg @SGRodriques @JocelynnPearl @EdisonSci C'mon industry already oversubscribed to the whole thing.
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Welp, I guess this is the path... of LLMs? My favorite LLM for scientific research (FutureHouse's Platform) is now part of @EdisonSci and only offers a $200/month option or enterprise option. Nothing in between?
Sad because I was actually using it to help patients.
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Good reminders from @mitsuhiko. Not just for software dev. Cannot count the number of times the “roots” have anchored me:
“I or someone else, planted something, and then I kept showing up, and eventually the thing had roots that went deeper than my enthusiasm on any given day.”
Armin Ronacher ⇌@mitsuhiko
“If someone 50 years ago planted a row of oaks or a chestnut tree on your plot of land, you have something that no amount of money or effort can replicate. The only way is to wait.” lucumr.pocoo.org/2026/3/20/some…
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@SGRodriques @JocelynnPearl @EdisonSci Nothing is free. So are you taking the researcher work to train your model or sell their user stats/info or both?
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Agree with sentiment, but the logic can be disproven by reviewing your own paper from >1-5 years ago. Knowledge, judgement, taste change within individual. Under some circumstances, an individual provides better “external” feedback to themselves than the available (and willing) alternative sources.
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Remember that you, by definition, cannot distinguish between a good idea and a failure of your own knowledge, judgement, or taste. This is why external (ideally expert) feedback is crucial
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@bobbyfijan Same shock moving Charlottesville -> Cambridge during infant days. On weekends most Cambridge coffee shops open at 8AM, vs plentiful 7AM options in small college town…
Dunkin is a drain on the universe
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Living in Center City as a parent of young kids ... the most ironically annoying thing about the coffee shops, was that not even Starbucks opened before 7am.
Dunkin was, literally, the only option.
Maddie@baddiemaddie43
The city vs suburb discourse is hilarious to me because you can’t convince me you’re happy living in a place that you have to use a car to go to a local coffee shop…
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@bijans Auchinsloss? PBMs arguably bigger source of waste than healthcare fraud.
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Some of this healthcare fraud video stuff is of course performative and bad use of data. But a lot of it isn't.
Yet, not a single Dem that I'm aware of at national/state/big city level is making the case for good government, efficiency, and catching and stopping healthcare fraud at its core.
They've handed the entire narrative to Rs.
That reputational hole / letting voters brand Ds as sclerotic, wasteful spenders, beholden to interest groups and who enrich fraudsters and raise your taxes to do so vs. the “efficient” R image will take a generation to climb out of.
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Not sure whether my point was misunderstood—relative to low COL states, MA is losing population. The driver is not high net worth individuals moving, though, it is people that are priced out (which is due to largely non-partisan, boring issues, not headline-grabbing issues). Cost tells us most of the story—MA is a very desirable place live. Infrastructure is incredible relative to other parts of USA, evident by COL.
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check the numbers of net out migration by tax-paying regular citizens in recent years in MA. Total population change is misleading due to the enormous per capita increase in relatively unskilled/needy immigrants (except on Nantucket) who are mostly here illegally. Please comment on our amazing, beautiful, well-functioning infrastructure and super low energy costs, the envy of the nation. And also how we have zero fraud and corruption. I look forward to continuing the conversation on these topics.
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My colleagues that I work with every day closely are amazing. The state - really not so great and I would love to live somewhere else. Every day it is something annoying, the legislature cares more about insisting that men can use ALL women's restrooms at my institution (a harsh law is enforced) than about fixing infrastructure.
Evan@StockMKTNewz
Residents exiting Massachusetts took a net of $4.2 Billion in adjusted gross income with them in 2023, one of the largest totals in the country, after a tax on millionaires took effect - Bloomberg
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Not disagreeing with specifics, but net flows of revenue and population suggest tax policy is beneficial and that when people speak with their wallets, they find the services provided and culture outweigh the costs.
Most issues causing migration out of MA are self-inflicted, non-partisan (e.g., localities non-compliant with MBTA communities act; local zoning constraining housing supply and inflating housing costs, etc.).
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Zeitgeist of normal taxpayers is still - what do we get for our money? A lot of social programs of questionable benefit (other than favorable press from legacy media for politicians and their friends), distracting from infrastructure problems that persist and degrade quality of life for all.
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@JustinPerryPhD @LindaGGriffith1 Well, the alternatives (theory-based modeling, extrapolation of empirical results from other regions with similar policies) generally find the same result as this analysis from the first year of implementation in MA.
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@LindaGGriffith1 @MedlockGreg A fixed time point analysis to argue why a millionaire tax is a net-benefit is quite misleading. We are facing similar things in CT, with the constant stream of punitive policies passed by a supermajority in the state. It's really sad to see, given how beautiful NE is.
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Greg Medlock retweetledi
For a Friday feed cleanser, this Afroman story is hysterical - and a win for the First Amendment!
reason@reason
An Ohio jury has found @ogafroman not liable for defaming the sheriff’s deputies who raided his house on a bogus tip. Read more: reason.pub/4rKT9dE
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Have any parents ever discovered that their 5 year old did indeed have a disease that made it too painful to walk?
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Greg Medlock retweetledi
We're searching for the next Director of the Duchossois Family Institute at UChicago
The most exciting leadership role in microbiome science right now: lead faculty, cutting-edge cores, an FDA-approved facility for microbiome therapeutics
Apply here: apply.interfolio.com/182203
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@emmma_camp_ The methodology for the survey doesn’t seem to be public, and only 877 preschool teachers responded (far lower numbers for k-3). Amongst preschool teachers, I don’t think tenure is long enough for even a modest fraction of those teachers to have been teaching pre-COVID.
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Genuine question: Does anyone know why this happened? Most of these kids weren't even born until after the pandemic.
Daniel Buck, “Youngest Old Man in Ed Reform”@MrDanielBuck
New Survey: 50% of kindergarten teachers report their students are having more difficulty using bathroom on their own? Look, schools cannot function if parents don't do even the basic minimum in teaching their own children to toilet independently What a disheartening survey
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Hopefully this experiment shows other folks how peer review and collaborative work are going to evolve with AI... you can just "do the thing" now. I came away with a much better understanding and appreciation of GPU-kallisto!
cc @lpachter
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I definitely found that the bgzip vs. gzip point in @pmelsted's paper is critical. GPU-kallisto takes 10X as long (which I learned through trial and error, as I did not catch in Claude's implementation that it did not use bgzip). Opus 4.6 also was not terrific at figuring out compilation issues (though this is a pretty unique approach). If anyone knows of skills out there that optimize this, I'd love to learn more.
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I was curious how @pmelsted's new GPU-kallisto implementation affects compute costs. Given the massive (50X!) improvement in speed, this wasn't straightforward.
Instead of just asking "ackchyually, is it cheaper", my friend Claude and I did the analysis!
Pall Melsted@pmelsted
Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv biorxiv.org/content/10.648… Figure 1 shows they key result
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