Bhattacharyya Lab

Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! doi.org/10.1101/2025.1…

March 17 is the deadline for abstract submission for Open Talks (in every session) and Travel Grants (up to 100) for our 40th Anniversary Symposium in Boston, MA. Don't miss it! Abstract fees are $15 for student members and $30, for non-members. proteinsociety.org

Consider applying for this Gordon conference on single molecule approaches to biology! Suliana Manley is the keynote speaker.

@JunLiuLab @YaleMed @YaleMicroPath Congratulations Jun, very cool!

Structural insights into the assembly and evolution of a complex bacterial flagellar motor nature.com/articles/s4156… @YaleMed @YaleMicroPath In collaboration with Beile Gao (CAS), Xiang Gao (Shandong University), Matt Baker (UNSW), and Maria Lara-Tejero (Yale University)

🚨 Postdoc Position Open 🚨 Study protein-DNA interactions w/ cutting-edge single-molecule imaging in our lab! Exciting projects perfect for ANRF-NPDF apps. Motivated postdoc candidates: Approach us! Mahipal Ganji ganji@iisc.ac.in ganjilab.org

Super cool work! I can see so many applications!!! Congratulations 🎉

Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: science.org/doi/10.1126/sc… 🧵

In the latest issue! Inhibition of oligomeric BAX by an anti-apoptotic dimer dlvr.it/TQ2MJy

Super excited to share our latest finding on the EGFR activation mechanism. In our paper, we found that cholesterol in the inner leaflets of the plasma membrane is essential for ligand dependent EGFR activation. science.org/doi/10.1126/sc…

This project was led by the very talented Dr. Shailesh Kumar and Harry Jung in my lab, with outstanding collaborative support from what was truly a dream team! Special thanks to Drs. Shyamal Mosalaganti and Yamuna Krishnan for making this fun!

Our findings have outsized implications for selective targeting of #ChronicPain without adverse effects on trophic signaling OR treatment of #neurodegeneration without eliciting dose-limiting pain. A detailed step-by-step description of this preprint is coming soon!

Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! doi.org/10.1101/2025.1…

FDA approves 100th small-molecule kinase inhibitor nature.com/articles/d4157…

Please join us on Nov 20th at noon in Brady Auditorium to hear about Moi Bhattacharyya's exciting work.

We now provide a molecular framework to uncouple the nociceptive from neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling. This finding has outsized implications for selective targeting of chronic pain and neurodegeneration.

Researchers in the Vosshall lab have discovered the first evidence of what happens when a female mosquito chooses to mate for the one and only time in her life. We spoke to @leslievosshall and @LeahHouri about their unexpected findings. See the full Q&A:rockefeller.edu/news/38495-wha…

Super-resolution single-molecule fluorescence meets quantitative phase contrast! This powerful combo enables ~0.05 nm optical path difference detection, < 20 nm resolution, and continuous live-cell imaging with digital staining, opening new windows into molecular dynamics!🔬

This is a game changer

@HuanBao4 Many congratulations Huan! Beautiful work, much well deserved! Cannot wait to use this.

Our DeFrND approach is finally published. A simple trick to isolate membrane proteins with native lipids for structural and functional characterization. doi.org/10.1038/s41467…

Many congratulations @JunLiuLab for this beautiful work!

The call just opened! ki.se/en/about-ki/jo… You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics ki.varbi.com/what:job/jobID…