Matt Waas

Last paper for 2024. Nice work by @mrwaas on proteomics of HNSCC tissues to identify novel biomarkers within the N0 population. Great collaboration with @laillesuhnrese1 and support from many colleagues @PMResearch_UHN

@massspecpro @pwilmarth We love it for the reduction of +1 ions, really helpful for low sample input

@pwilmarth @mrwaas I don't think that's true. I've heard from many users who gladly use FAIMS to (1) knock down co-isolation of unwanted precursors and (2) improve instrument robustness. It has had its share of implementation issues, but it definitely has a place in some bottom up workflows.

Congratulations ⁦@mrwaas⁩ for securing the cover for his Dropps paper cell.com/cell-reports-m…

Checkout our new paper, describing a simple method to analyze low amounts of flow sorted cells by @mrwaas and team Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium: Cell Reports Methods cell.com/cell-reports-m…

Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous Ovarian Carcinoma | Journal of Proteome Research pubs.acs.org/doi/10.1021/ac…

We have a job opening for a Research Associate/Mass Spectrometrist in the lab. If you are interested, please apply through the link below. Four mass spectrometers to work with and lots of cool clinical proteomics and cell surface marker projects to work on.

@ProteomicsNews Use zotero with chrome plugin. Easiest and best citation manager!

Droplet based low input proteomic platform for rare cell populations | buff.ly/3r2FuFJ #proteomics

@NanoPOTS_SCP @mathepan DROPPS can help discover some new biology, is really easy to implement and, very inexpensive to set up. Thanks to @amandakhoo4, @c_mccloskey1, @meinusha, @rmkhokha, @KislingerThomas and all the coauthors not on x(?)! Reach out if you have any questions or comments. (end)

@NanoPOTS_SCP @mathepan We identify and validate CD36 as a marker of high mitochondrial activity with enhanced clonogenicity in the basal epithelium and uncover that this may be related to CD36's ability to rewire metabolism towards fatty acid utilization. (6/x)

Introducing DROPPS! Here's our preprint that describes an accesible approach to low input proteomics and how we applied it to generate some interesting biological insights (1/x) biorxiv.org/content/10.110…

And here is a link to the pre-print biorxiv.org/content/10.110…

Happy to report our latest collaborative work with the Boutros Lab utilizing proteomics of prostate cancer urines is now available in @biorxivpreprint @PMResearch_UHN @TheBoutrosLab @UCLA

Check out @AnnieHahkl ‘s poster on using 💧urine + EV spectral libraries to increase protein detection in urine by DIA-MS! ➡️ThP 040 #ProstateCancer #biomarkers #DIA #ASMS2023 @KislingerThomas

Go see the inimitable @amandakhoo4 tour de force on the how prostate cancer reshapes the secreted and EV urine proteome! Poster 112 #ASMS2023 #Extracellularvessicles #prostatecancer #biofluids #urineproteomics