Meinusha

Checkout our new paper published in @CellRepMed. cell.com/cell-reports-m… Fantastic work by Meinusha Govindarajan @meinusha and Salvador Mejia-Guerrero with lots of help from our many collaborators and colleagues. #glycotime

Checkout the latest preprint from @meinusha - the final part of her PhD Surface proteomics reveals arginine metabolism as a vulnerability in high grade serous ovarian cancer biorxiv.org/content/10.110…

checkout our latest paper in @NatureBiotech. We developed a graph-based algorithm that comprehensively generates non-canonical peptides in linear time. nature.com/articles/s4158…

Excited to share our first lab paper, now published in @Dev_Cell! 🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?

CSF protein biomarkers are associated with response to multi-agent intraventricular chemotherapy in patients with CNS lymphoma academic.oup.com/noa/article/do…

Our study on T-ALL heterogeneity is out! We show ~1/3 of T-ALLs express inflammatory/stem signatures and are sensitive to venetoclax. Huge congrats to @gowerfulScience for leading the way, @s_jahangiri, and the entire team! science.org/doi/10.1126/sc…

Last paper for 2024. Nice work by @mrwaas on proteomics of HNSCC tissues to identify novel biomarkers within the N0 population. Great collaboration with @laillesuhnrese1 and support from many colleagues @PMResearch_UHN

Big effort (> 7 years) from a large number of colleagues. Finally on BioRxiv and to be submitted in January Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers biorxiv.org/content/10.110…

Nice work by Matt @mrwaas and rest of the team to put this protocol together Protocol for generating high-fidelity proteomic profiles using DROPPS sciencedirect.com/science/articl…

Proteomics on 800 urine fractions from prostate cancer patients (soluble fraction and EVs). Outstanding work by @amandakhoo4 @meinusha and Zhuyu Qui. It was a long process to get this published nature.com/articles/s4146…

Come check out @mrwaas awesome poster on using DROPPS to dissect mammary stem cell heterogeneity at MP 773 @KislingerThomas #ASMS2024

Congratulations ⁦@mrwaas⁩ for securing the cover for his Dropps paper cell.com/cell-reports-m…

moPepGen: Rapid and Comprehensive Proteoform Identification pubmed.ncbi.nlm.nih.gov/38585946/

Second paper in two days. Great work by @AnnieHahkl and @amandakhoo4 Comprehensive Prostate Fluid-Based Spectral Libraries for Enhanced Protein Detection in Urine | Journal of Proteome Research pubs.acs.org/doi/10.1021/ac…

Checkout our new paper, describing a simple method to analyze low amounts of flow sorted cells by @mrwaas and team Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium: Cell Reports Methods cell.com/cell-reports-m…

Checkout our new article published in Acta Neuropathologica Communications by former PDF Shahbaz Khan in collaboration with @gelarehzadeh doi.org/10.1186/s40478…

And ⁦@mrwaas⁩ has his poster on rare cell populations (poster 5.159). Come and check it out

Come and visit ⁦@meinusha⁩ at her amazing poster on glycoproteomics in PDX models (poster 5.53)

Latest preprint from the lab. A simple method for the proteomics analysis of rare cell populations. Developed by post-doc @mrwaas biorxiv.org/content/10.110…

Introducing DROPPS! Here's our preprint that describes an accesible approach to low input proteomics and how we applied it to generate some interesting biological insights (1/x) biorxiv.org/content/10.110…