
Michael Griffiths
5.5K posts




Espina Bundley made a tiny little error — the kind millions of New Yorkers make every single day — and she paid with her life early on Wednesday morning the driver of a 4,000-pound SUV traveling at high speed slammed into her on Second Avenue, cops said. nyc.streetsblog.org/2026/03/27/cyc…






"The top 1 percent of American households, which have a minimum net worth of $11.1 million, now collectively own about $25.6 trillion worth of stocks and mutual funds, the same amount as the remaining 99% of the country," per the Federal Reserve

How AI empowered Paul Conyngham to create a custom mRNA vaccine to cure his dog’s cancer when she had only months to live. The first personalized cancer vaccine designed for a dog:






I packaged up the "autoresearch" project into a new self-contained minimal repo if people would like to play over the weekend. It's basically nanochat LLM training core stripped down to a single-GPU, one file version of ~630 lines of code, then: - the human iterates on the prompt (.md) - the AI agent iterates on the training code (.py) The goal is to engineer your agents to make the fastest research progress indefinitely and without any of your own involvement. In the image, every dot is a complete LLM training run that lasts exactly 5 minutes. The agent works in an autonomous loop on a git feature branch and accumulates git commits to the training script as it finds better settings (of lower validation loss by the end) of the neural network architecture, the optimizer, all the hyperparameters, etc. You can imagine comparing the research progress of different prompts, different agents, etc. github.com/karpathy/autor… Part code, part sci-fi, and a pinch of psychosis :)

A masterclass from @jeremyphoward on why AI coding tools can be a trap -- and what 45 years of programming taught him that most vibe coders will never learn. - AI coding tools exploit gambling psychology - The difference between typing code and software engineering - Enterprise coding AND prompt-only vibe coding are "inhumane" i.e. disconnecting humans from understanding-building - AI tools remove the "desirable difficulty" you need to build deep mental models. Out on MLST now!







