Nima Alidoust

1.8K posts

Nima Alidoust banner
Nima Alidoust

Nima Alidoust

@nalidoust

CEO and Co-Founder, @tahoe_ai, Princeton PhD *15 زن، زندگی، آزادی

Katılım Mart 2015
621 Takip Edilen3.4K Takipçiler
Sabitlenmiş Tweet
Nima Alidoust
Nima Alidoust@nalidoust·
Introducing Tahoe-x1 (Tx1) by @tahoe_ai. A 3-billion-parameter, single-cell foundation model that learns unified representations of genes, cells, and drugs, achieving state-of-the-art performance across cancer-relevant cell biology benchmarks, open-sourced on @huggingface. 🧵
English
39
224
1.3K
170.1K
Nima Alidoust
Nima Alidoust@nalidoust·
... and provides a way to generate testable hypotheses about convergence between perturbations and about regulatory edges that are not captured in existing references.
English
1
0
0
245
Nima Alidoust
Nima Alidoust@nalidoust·
In our new blog post, we team up with @NVIDIAHealth to make it possible to map how drug effects cascades through gene regulatory networks.
Nima Alidoust tweet media
English
2
16
67
9K
Bo Wang
Bo Wang@BoWang87·
Today we’re announcing X-Cell — Xaira’s first step toward a virtual cell. 🧬 A foundation model that predicts how gene expression changes under causal perturbations — across cell types, conditions, and even unseen biology. This is not trained on observational atlases. It is trained on interventions. 🧵👇
English
42
144
940
148.4K
Nima Alidoust retweetledi
Zavain Dar
Zavain Dar@zavaindar·
inspired by writings of @karpathy & @ericjang11 we built an autoresearcher via Claude & @modal within 48 hours we’d beat published baselines in protein thermostability we’re not pivoting to a neolab 🙃 but here’s what a small team w curiosity & gumption can do w todays tools
Frank Gao@ChemVagabond

We @_DimensionCap ported @karpathy's autoresearch framework to biology. We let Claude run 50 experiments over the weekend on protein thermostability prediction via @modal. It beat a recent baseline (TemBERTure) using a 20x smaller model. Code + research blog later this week!

English
2
6
82
11.7K
Nima Alidoust retweetledi
Hani Goodarzi
Hani Goodarzi@genophoria·
Before there was @tahoe_ai's Mosaic platform, which gave us Tahoe-100M, there was GENEVA. This is the paper that started it all — and it's been a long time coming.
Hani Goodarzi tweet media
English
5
12
61
12.2K
Nima Alidoust
Nima Alidoust@nalidoust·
How we are measuring drug interaction with patient-derived cells in vitro and vivo to train AI models of the cell is now in Nature Cancer! Enjoy
Johnny Yu@iamjohnnyyu

1/ The technology behind @Tahoe_ai is now published in Nature Cancer. GENEVA: pool diverse disease models into one mosaic tumor → treat → deconvolve response at single-cell resolution. The architecture that had to exist before datasets like Tahoe-100M were possible.

English
1
3
26
4.6K
Nima Alidoust
Nima Alidoust@nalidoust·
@HafezeSayeha الان فرماندهی غیرمتمرکز دارند. واحدها به‌طور مستقل تصمیمات حمله می‌گیرند.
فارسی
0
0
3
554
Nima Alidoust retweetledi
Nima Alidoust
Nima Alidoust@nalidoust·
What was his religious role. This is at best very superficial knowledge of Khamenei’s status as a religious leader and his rise to that position. Akin to “He is a cleric, hence he has respect and authority”. I don’t have too many qualms with the price. But this part is just lazy.
Nima Alidoust tweet media
English
1
0
5
604
Ben Golub
Ben Golub@ben_golub·
Lots of wisdom here on the political economy of this
Daron Acemoglu@DAcemogluMIT

On Iran and Anthropic: Robert Mugabe, Zimbabwe’s dictatorial president since 1987, won the big prize in the country’s lottery in 2000. Why did he go out of his way to concoct such a charade? A surface-level answer: Because he could. Once you destroy institutions constraining your power and behavior, you can act in largely unrestricted fashion, whether it is for personal enrichment, personal aggrandizement, or simply projecting even greater power. But there is a deeper, more problematic answer as well: What better way to further decimate institutional checks on your power than showing how much of a farce the existing system of rules is. It is not just a coincidence that such behavior can do damage to norms, institutions and security and stability of the country. It is part of the design. Mugabe’s lottery win echoes in two fateful decisions by the Trump administration, which will have long-lasting and troubling implications, are just. Trump and his allies are pursuing these actions because they can and because these actions are consistent with their agenda of upending all rules and constraints on their future behavior. The first problematic action is the US-Israeli attack on Iran and the killing of the country’s supreme leader Ayatollah Khamenei. Leave aside the loss of life and the immediate chaos, it should be obvious that such a move will trigger a long period of instability in the Middle East. There should be no doubt that the Iranian regime was repressive, murderous and bad news for its own people’s economic and social well-being. The supreme leader, leading Iranian elites and the country’s feared Revolutionary Guard had blood in their hands and the repression had intensified lately. But none of this justifies the United States and Israel initiating a war in the Middle East, without support from international allies or from the public in the United States (still considered a democracy where people’s views should in principle matter). But even worse, this act violates the sovereignty of another nation and risks plunging the entire region into carnage. And however awful Ayatollah Khamenei’s track record may be, he’s no Nicolas Maduro (who had only a few diehard supporters even in the Venezuelan military). By virtue of his religious role, Khamenei enjoyed respect and authority among the Shiites and even the broader Muslim mission community, and his killing risks turning him into a martyr, which is the last thing that Iran or the region needs. The second is the Department of Defense (it is still painful to call it the Department of War even if recent actions confirm that this change of name wasn’t just for optics) designating the AI company Anthropic a supply-chain risk. The official designation is typically used for companies from foreign adversaries, such as China’s Huawei. It bars federal contractors using the Anthropic’s models and heralds major restrictions on what the company can do in the future. The Secretary of Defense Pete Hegseth announced “Effective immediately, no contractor, supplier, or partner that does business with the United States military may conduct any commercial activity with Anthropic.” The reason? Because Anthropic wanted safeguards against its models being used for mass surveillance of Americans and autonomous weapon systems. Neither of these two provisions would have put meaningful restrictions on the DoD in practice. Mass surveillance is illegal under US law and autonomous weapon systems are a not near-term possibility. Yet, it is the showdown that matters, just like Mugabe’s lottery winning. This action will also have major consequences, perhaps more far-reaching than the attack on Iran. Regardless of what one might think of current AI capabilities, there is little doubt that who controls AI will have momentous implications for democracy, business, communication and privacy. This designation can be interpreted by many in the industry that it will be the US government, not the private sector, that controls AI. Even more far-reaching are the broader implications of this action: this administration, and perhaps future administrations, can now bring hugely disproportionate penalties on any contractor they disagree with. Security of private property rights, which has been a mainstay of American state-business relations for centuries, is now looking much shakier. It also sends exactly the wrong signal to the world that Pentagon is intent on mass surveillance and the development of autonomous weapon systems (why else bother about these two ineffective provisions in the contract?). The absurdity of both actions is what harkens back to Mugabe’s lottery win. Trump came to power promising no foreign adventures, and now has spearheaded a potentially riskier one than the Iraq war, with even flimsier justification. There would have been no bite to the provisions that Anthropic wanted in the contract, since current AI systems are nowhere near reliable to be used in autonomous weapon systems and the US government has plenty of other tools that can be (and sometimes are) used for mass surveillance. The shock value and the norm breaking are part of the intent. Mugabe’s lessons continue.

English
12
6
107
45.4K