Xiaolin Nan

30-COLOR DNA-PAINT at sub-15 nm RESOLUTION. I am overly excited to tell you about "Spatial proteomics in neurons at single-protein resolution" our latest work led and developed by my brilliant and amazing colleague Eduard Unterauer. 1/8 biorxiv.org/content/10.110…

@christlet @HenriquesLab We use sheared salmon sperm DNA plus a so-called signal enhancer from ThermoFisher. Sometimes either suffices but we usually include both. onlinelibrary.wiley.com/share/author/D…

In this article, @nanxiaolin @Scientistic212 et al (@OHSUKnight) provide a detailed guide for fast and multiplexed superresolution imaging on cells using DNA-PAINT-ERS, with many useful tips for great results. …rentprotocols.onlinelibrary.wiley.com/doi/10.1002/cp…

#STED at Å precision! See nature.com/articles/s4158… New article by Weber, von der Emde et al. Fantastic applications ahead; stay tuned! #Nanoscopy #Superresolution #Microscopy @mpi_nat

Research Highlight by @rita_strack: Researchers use electric fields to transfer RNA from a tissue onto a surface for subsequent FISH-based spatial transcriptome analysis. Paper: nature.com/articles/s4158… Highlight: nature.com/articles/s4159…

The tools for getting the most information out of highly multiplexed tissue imaging data are just getting better and better. From a methods perspective, it's so fun to see a big wave of new acquisition methods followed by a second, huger wave of analysis tools. Check out UTAG!!

SOOO EXCITED to finally, officially introduce CODA, a method for 3D reconstruction by myself,PeiHsun Wu @deniswirtz, and @lauradelongwood

We present doubled resolution in light-sheet microscopy via multi-directional structured illumination. This enables SIM imaging at 1Hz volume rate of subcellular dynamics. nature.com/articles/s4159…

Very proud of our work published today on noncoding genes that are essential for chromosome stability. More to come soon. nature.com/articles/s4146…

🚨Hot off the press in @NatureMedicine👉After KRAS G12C going after the next undruggable-KRAS G12D👉Anti-tumor efficacy of a potent & selective non-covalent KRAS G12D inhibitor 🎯🧬Huge implications in #precisionmedicine if translated to clinic @oncoalert go.nature.com/3ExqaoJ

High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging go.nature.com/3CN3vnj

Physics is stochastic but biology is deterministic? Or, biology is stochastic but physics is deterministic? If you are puzzled by the questions, look no further but at the 2023 GRC Stochastic Physics in Biology grc.org/stochastic-phy…. Join us!

Nanoscopic Spatial Association between Ras and Phosphatidylserine on the Cell Membrane Studied with Multicolor Super Resolution Microscopy mdpi.com/1745068 #mdpibiomolecules via @Biomol_MDPI

🚨🔬😍 Our review on mapping molecular complexes through #SuperResolution #Microscopy is out!! Highlighting many recent exciting studies. A brainchild of @afonsomendes92 and @Hannah_SuperRes in collaboration with @simaopc and @christlet. Check it out at doi.org/10.1098/rsob.2…

Multipair Förster Resonance Energy Transfer via Spectrally Resolved Single-Molecule Detection pubs.acs.org/doi/10.1021/ac…

@RetoPaul @kD3AN Congratulations Reto!

@kD3AN Thank you all for the well wishes. Both Pümperlis are well, and so is their mother🥰!

Achieving single nucleotide sensitivity in direct hybridization genome imaging biorxiv.org/content/10.110…

A very nice Review on multiplexed imaging in oncology out in NBME from Ralph Weissleider and colleagues. I spend so much time thinking about basic science, I love seeing how all this work impacts medicine. nature.com/articles/s4155…

Actin cytoskeleton branching complex: PDB 7TPT #blender #Blender3d #b3d

That @BMESociety abstract deadline is coming up quick, so here’s your annual reminder…