Nathan Ewing-Crystal

8/ Very proud of this work, represented here by the amazing @prenderghost, and excited to see where this field goes next!

7/ Overall, our work highlights the importance of brain fibroblasts after injury, raising the possibility of new therapeutic opportunities for stroke and TBI involving finetuning fibroblast states/transitions to achieve optimal wound healing and immune responses.

1/ Thrilled to share that my PhD thesis work is now out in its final form @Nature! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @Molofsky_lab. nature.com/articles/s4158…

@lcdsmyth @EgleKvedaraite Thank you! And great question - we think TGFb is likely more of an initiation/early activation signal than a maintenance signal, but we’re actively working on testing that!

@nathanec1 @EgleKvedaraite Wow! I love this so much!! Beautiful work🤩 I wonder if you inhibit TGF-B signaling after the resolution of the wound healing if the FBs return to their 'resting' state?

1/ Excited to share my thesis work, now out as a pre-print: “Dynamic fibroblast-immune interactions shape wound healing after brain injury” biorxiv.org/content/10.110…

11/ Immensely grateful for colleagues in the @Molofsky_lab, Arnold lab, and @AnnaMolofskyLab, and collaborators in @ManishKAghi, @drjamesbourne, @HelenaPaidassi, @JeanneTPaz, @COCOshaveice, and Dean Sheppard labs. Special thanks to @nick_mroz, Anthony Chang, and @SofiaCaryotakis!

10/ Collectively, our data highlight the unexpected role of brain fibroblasts and their immune interactions after injury. As stromal cells have been recently implicated in human brain pathology, fibroblasts may represent important future therapeutic targets.