Nick Bennett

So true

Cancer vaccines are showing marked efficacy vs refractory cancers and are going to be part of the future Rx armamentarium. Beyond that, ultimately, for prevention in high-risk individuals. A new stellar review @NatureMedicine nature.com/articles/s4159…

A single course of antibiotics can disrupt your gut microbiome for up to 8 YEARS, according to this new Nature Medicine study 💊🤯 Avoid antibiotics unless absolutely necessary and consider taking probiotics to counteract these effects.

@amasad Congrats Amjad and team! Incredible growth.

We’ve raised $400M at a $9B valuation. Investors include Georgian, G Squared, Prysm, 1789, YC, Coatue, a16z, Craft, and QIA, with strategic investments from Accenture, Databricks, Okta, and Tether. We’re also lucky to have incredible individuals backing us, including Shaq and Jared Leto. This funding will help us scale our ambition and expand beyond coding into AI systems that center human creativity. Replit is now used at 85% of the Fortune 500. We have an opportunity to help shape the future of work. One where AI abstracts away the boring parts and humans shine as creative directors. We’re also investing more globally, particularly in Europe, Asia, and the Middle East. Innovation can come from anywhere in the world, and we want to help unlock it.

Locked up a 2 seed after that performance. Such a fun team to watch.💪

@gregisenberg In all fairness, companies have been and will always be pivoting.

every company is pivoting right now

Worthwhile read and simple tips to shift your approach during engagements. cnbc.com/2026/02/16/peo…

@rohanpaul_ai It’s a catchy line but does any company offer zero cost SaaS development at scale? Low(er) cost relative cost and accessibility vs traditional SaaS dev, sure. Every company (and AI use) has costs and someone has to pay.

Sebastian Siemiatkowski, the co-founder and CEO of Klarna: SaaS is Dead. "The cost of creating software is going down to zero. And that means everyone will be able to generate software at any point in time. " But the real threat to SaaS will shows up next when AI makes data migration one-click—no more hostage data models, no more painful switching costs. --- From '20VC with Harry Stebbings' YT channel ( link in comment)

🆕⚡🟢CEFTOX (AAC 2026) ⚠️ High-Dose Cefepime in the ICU: Safe or Overexposed? Frequent cefepime overexposure with continuous infusion — even in patients with normal renal function. Early TDM made a meaningful difference in neurotoxicity. Dose thoughtfully. Monitor early #IDXposts journals.asm.org/doi/10.1128/aa…

@AllisonRBond 🙋🏻‍♂️ Much more quiet than it used to be but I’m finding that’s not always a bad thing. Still get a lot of value but depends on personal use case for the platform.

Does anyone from #MedTwitter still use this app?

Loved watching the Iowa Women’s basketball team during the Clark era but the current team is solid top to bottom. Put Clark on this team and they might be celebrating a title. #iowahawkeyes

Learning to delay gratification and play the long game is critical to most worthy endeavors.

@chamath Think this is where solopreneur SaaS era starts?

We've talked a lot about this on the Pod, but the Great SaaS Meltdown has started and there's no going back. What exactly is happening? In short, hi growth, low/no profitability SaaS is no longer a winning strategy because the big question mark is the durability of that growth in the short term and, because of AI, the lack of profits in the long term. Every SaaS company has sold the dream (to investors and employees) that they will growth quickly now, and harvest lots of cash later. With AI, this assumption may be completely out the window. Now the threshold question is whether their growth will be overtaken by a much cheaper AI-developed solution? If you are a venture supported SaaS startup and are a legacy Heuristics+APIs+CRUD product, it is likely that a new AI oriented workflow is coming for you. Investors in private markets can see this now and think that money to fund short term growth will not be rewarded. Investors in public markets no longer believe long term profitability is possible. They would rather pivot into something they think is more resilient. This is a change in the risk calculus that has existed for the past 15 years and why the chart below is the chart below. Good luck to all the players!

Incredible

Online sports gambling is destroying a generation of young men.

Watch this before you abandon your New Year’s goals. 👇

This is probably one of the greatest lessons for life. "If you’re having fun, then you’re dangerous, right? Then you’re hard to compete with. You don’t want to go up against the person who’s having a good time doing it because if it feels like a hassle or a chore, that’s the person who gives up when it gets difficult. But the person who’s having a great time at the start is much more likely to stick with it when it gets hard." (James Clear on The Knowledge Project)

🔑 The secret to truly sustainable solutions: We build what we think is best. Users/adopters do what requires the least effort. Human nature is "lazy"—we conserve energy, avoid friction, think minimally. Design EVERY solution (products, services, policies, systems) around this reality. Make it effortless…or it won’t last.

Your Mindset is your single most critical success tool. It determines how you deal with threats and opportunities. What mindset(s) do you have? Where did you get it? What mindset do you need for the decade ahead.

Good morning from Tampa! Every Hawkeye is suiting up for the ReliaQuest Bowl vs. Vandy. As other programs opt out entirely from bowls, Iowa remains all-in. “I just know how strong the culture is ... and I couldn't really imagine it in any other way.” hawkcentral.com/story/sports/c…