@CharlesSwanton @LabPolyak @DFCI_BreastOnc @oesterreichs @Adrianvlee @ZheqiL Thank you! Still requires more work to figure out all details of how WGD triggers metabolic changes, but it all makes sense.
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Kornelia Polyak
453 posts
Kornelia Polyak
@nellage
Dana-Farber Cancer Institute @DanaFarber, Harvard Medical School @harvardmed, @MSKCancerCenter, Weill Cornell @WeillCornell, Johns Hopkins @hopkinskimmel
Boston Katılım Nisan 2008
373 Takip Edilen553 Takipçiler
@nellage @LabPolyak @DFCI_BreastOnc @oesterreichs @Adrianvlee @ZheqiL What a tremendous discovery Nelly many congratulations
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Kornelia Polyak retweetledi
Happy to share our new manuscript: Whole-genome doubling drives immune evasion by silencing antigen presentation: Cancer Cell cell.com/cancer-cell/fu… @LabPolyak @DFCI_BreastOnc @oesterreichs @Adrianvlee @ZheqiL
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Kornelia Polyak retweetledi
Since launching @LabPolyak in 1998, Kornelia Polyak, MD, PhD, has focused on a fundamental question: how does breast cancer form? New research suggests that shifts in immune activity may be one of the earliest steps. Learn more: bit.ly/4sXDUP3
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Kornelia Polyak retweetledi
New @Cancer_Cell paper from @LabPolyak: Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression
👉pubmed.ncbi.nlm.nih.gov/41997138/
@ZheqiLiu @yan_pengze @umd_emd @QinYan1
@Adrianvlee @DrShelleyHwang @simocristea @nellage
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Kornelia Polyak retweetledi
New study from @LabPolyak now out in @CD_AACR: HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies
pubmed.ncbi.nlm.nih.gov/41925564/
@yan_pengze @ZheqiLiu @sflomos @nellage
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Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression: Cancer Cell cell.com/cancer-cell/fu…
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HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies aacrjournals.org/cancerdiscover…
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HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies aacrjournals.org/cancerdiscover… @LabPolyak @DFCI_BreastOnc
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Kornelia Polyak retweetledi
New study from the @LabPolyak on aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in #BreastCancer
🔓pubmed.ncbi.nlm.nih.gov/41719331/
@yan_pengze @nellage @PNASNews
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Do not ship precious perishable samples with #FEDEx especially not international. Even if they have all paperwork they don’t deliver in time - they do not care.
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Kornelia Polyak retweetledi
Dr. Kornelia Polyak (@nellage) discussed the molecular and immunological basis of #BreastCancer across the age continuum in the #SABCS25 session on breast cancer in young women. @LabPolyak
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Congrats to Dr Ian Krop @YaleCancer on the Bonadonna Award, honoring his practice-changing work in breast cancer!
Wonderful introduction from @DrEricWiner.
Critical importance of:
-mentorship
-industry collabs
-investigator initiated trials
-funding
-family
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Kornelia Polyak retweetledi
Our study on histone tail cleavage is out today in @NatureGenet . We found KDM4C prevents CTSL-mediated histone H3 tail clipping by modulating its recruiter GRHL2, reducing oxidative stress and promoting basal tumor growth. Congrats to @ZheqiL @nellage
nature.com/articles/s4158…
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happy to share our manuscript that just came out in Nature Genetics, it took us more than 10 years to solve this puzzle.
nature.com/articles/s4158…
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This will harm cancer centers, where most cancer research is done. They don’t have endowment. Why would anyone want to destroy hospitals that work on saving lives???
NIH@NIH
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.
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Kornelia Polyak retweetledi
Very grateful to @CD_AACR for writing a comprehensive Research Watch for our work on aging and breast cancer.
aacrjournals.org/cdnews/news/18…
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Sadly I will miss the first Halloween MCO party, but at least our lab is represented.
Polyak Lab@LabPolyak
🎃Polyak lab is getting ready for the MCO halloween pumpkin decoration contest! Huge shoutout to @MarieAnneGoyet1 and Andriana who made this piece of work based on the lab logo! Science and creativity go hand in hand!
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and our first aging paper is out! @LabPolyak @DFCI_BreastOnc
Midkine as a driver of age-related changes and increase in mammary tumorigenesis: Cancer Cell cell.com/cancer-cell/fu…
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