Simona Cristea
4.6K posts

Simona Cristea
@simocristea
cancer genomics AI scientist; director of applied AI at @TempusAI; prev faculty @DanaFarber & group leader @Harvard & phd @eth; journey: 🇷🇴🇸🇪🇨🇭🇺🇸
Boston 🇺🇸 & Zurich🇨🇭 Katılım Ocak 2016
508 Takip Edilen9.5K Takipçiler
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@WillManidis this is real. kudos to you for experiencing all this and for putting it into words
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Simona Cristea retweetledi

@krishnanrohit i think this will stop soon, as it’s also i believe not such a good deal for high impact journals who are all into very relevant, “timeless” stuff
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@SashaGusevPosts creative writing is really tough though; it seems much more than writing functional code for everyday needs
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Simona Cristea retweetledi
Simona Cristea retweetledi

The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
nature.com/articles/s4159…

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Simona Cristea retweetledi

In a new Science study, researchers train a neural classifier to spot #AI-generated Python functions in over 30 million GitHub commits by 160,097 software developers, tracking how fast, and where, these tools take hold.
The researchers find that #AI currently writes an estimated 29% of Python functions in the U.S., a shrinking lead over other countries. scim.ag/3Z0qWnm

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On December 28th 2025, 98.6% of all trains running in Switzerland were on time 🇨🇭
About Switzerland@AbtSwitzerland
🚆 Swiss trains take punctuality very seriously. ⏱️ In 2025, Swiss Federal Railways reached 94.1% punctuality (+0.9 pts vs 2024). A record was set on 28 December with 98.6% of trains on time. Success thanks to reliable infrastructure, mild weather and staff commitment. Freight also improved to 90.2% (+2.2 pts). ℹ️ bit.ly/3LJtMdr
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Norway is the most beautiful country I've been to. It's a little hard to explain why until you see it -- the photos are excellent, but it's a distinct feeling when you're there. It's as though you're a bit closer to the thin veil between worlds or something.
Will Manidis@WillManidis
norway, 2025
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After 9 months, 5 rounds of chemo, and getting to ring the cancer-free bell, we got to come home today from @StJude. Definitely counting our blessings over the holidays and so happy to be home.


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I’m pleased to share that I am joining @NVIDIA Ventures as Portfolio Manager today. After spending the past several years immersed in the world of tech and techbio startups, building products, partnering with founders, and helping scale technologies, this transition feels like a natural evolution.
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@simocristea Preprint: doi.org/10.1101/2025.1…
CyteType Python SDK (AnnData): github.com/NygenAnalytics…
Română

Only a matter of time before a paper formalized this exercise:
Automated #scRNAseq cell type annotation with GPT4, evaluated across five datasets, 100s of tissues & cell types, human and mouse.
A🧵below with my thoughts on how such tools will change how #Bioinformatics is done.

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@simocristea This post has aged really well in predicting the impact LLMs will have on cell annotation. However, Hou and Ji's relied on the LLMs' knowledge and provided no way of guarding against hallucination. CyteType's agentic architecture changes that and outperforms GPCelltype by 388%.
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Today CZI is announcing an unprecedented new scientific initiative to build the future of AI-powered biology. I am joining CZI to lead this initiative as Head of Science, and the EvolutionaryScale team is joining forces with Biohub.
This is the first large scale scientific effort to combine frontier AI and frontier biology.
I feel an incredible sense of optimism in this moment. There is a path to build predictive models of life that can fundamentally accelerate science, and unlock a new understanding of disease.
biohub.org/blog/frontier-…
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@cremieuxrecueil it is known that inflammation is facilitating tumor initiation and progression
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I'm not taking a stance on whether inflammation drives cancer, but I will say it's very true that GLP-1 drugs reduce inflammation—a lot!
Tirzepatide at any dose greatly reduced levels of high-sensitivity C-reactive protein and interleukin-6, two important inflammation markers:

Simone Syed@SimoneSyed
@cremieuxrecueil Chronic inflammation is a driver of cancer. Glp1s help mitigate that fr
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