Nonia Pariente

An exciting new beginning today as I join @PLOSBiology as Editor in Chief! As the flagship PLOS journal in the life sciences, we aim to be a selective, fair, open access venue to ALL fields, to help advance discovery, depressurize the publication process & drive #openscience

How to get bacteria to move from the gut into the brain? —eat a high-fat diet —vagus nerve is the conduit —in the mouse model journals.plos.org/plosbiology/ar…

@gonzamoratorio Vamos Gonza ánimo y adelante!

💪💪💪 Vamos!!!

@gonzamoratorio Gonza cuánto lo siento! Fuerza y suerte en la lucha amigo. Te mando un abrazo fuerte desde acá

Cuantas vidas salvan las vacunas? Se estima que salvan 6 vidas por minuto en los últimos 50 años !! 👇

Vacciness have saved > 6 lives/min in the last 50 years, yet their importance & safety is often questioned “We should not allow misinformation, disinformation, ignorance and defunding to hinder vaccine development, deployment & use” My latest editorial journals.plos.org/plosbiology/ar…

My new article in @PLOSBiology out today. If you are a new- early- mid-career scientist or physician-scientist: Your future is not bleak, you are more powerful than you even realize. But it's different, the old way of NIH-K-R01-R01-P30 may shift, but there are new opportunities especially in biohubs. Here's the link to my paper journals.plos.org/plosbiology/ar…

NEW: My latest article out this afternoon in ⁦@PLOSBiology⁩ journals.plos.org/plosbiology/ar…

Antibiotic discovery is notoriously hard and slow. What if we could change that by optimizing antibiotics on the computer? Introducing APEXgo, our latest AI model, which integrates a transformer-based variational autoencoder with Bayesian optimization to design novel antibiotics. Unlike traditional AI approaches, which rely on fixed databases of known molecules, APEXgo explores uncharted sequence space, proposing entirely novel peptides that have not been seen before. We put APEXgo to the test with a bold challenge: could it design optimized compounds with antibiotic activity using templates from extinct organisms like woolly mammoths and giant sloths? 🐘🦣 The results? 🤯 · 100 peptides were synthesized and characterized for antimicrobial activity, mechanism of action, secondary structure, and cytotoxicity. · APEXgo achieved an 85% experimental hit rate. · 72% success in improving activity against dangerous Gram-negative pathogens —a major challenge. · The antibiotics designed by APEXgo were effective in mouse models, even outperforming polymyxin B (a last-resort antibiotic). This work represents the first ground-truth experimental validation of generative Bayesian optimization in any setting, and we are excited that its debut application is in antibiotic discovery. With APEXgo, we have entered an era where AI accelerates antibiotic discovery and explores molecular diversity at digital speed. #AI #Antibiotics Huge congratulations to my amazing Team and collaborators on this achievement: @mdt_torres, Yimeng Zeng, Fangping Wan, Natalie Maus, and Jake Gardner @Penn @PennMedicine @PennEngineers Link to the paper: biorxiv.org/content/10.110…

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Such a cool anti-phage defense system 🧪

First detailed modelling publication on Dengue virus importation risks in Africa, this seminal paper shows that African countries are being more exposed to outbreaks and epidemics. A thread 🧵thelancet.com/journals/lanpl…

Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 EMBL Annual Poster to include even more courses and conferences for you to join, so go and have a look! ➡️ s.embl.org/poster-x #EMBLEvents #molecularbiology #lifesciencetraining

Meet our plenary speakers! We are pleased to announce the distinguished plenary speakers for HGM2025. Come and listen to valuable perspectives shared by distinguished experts and leaders! See you all at HGM2025! Register Now: hugo-hgm2025.org/registration/

The updated programme is available on the website: hugo-hgm2025.org/programme/ Don’t forget to register. See you in Durban! Register Now: hugo-hgm2025.org/registration/ Submit Abstract: hugo-hgm2025.org/abstract-submi… Apply for Travel Grant: hugo-hgm2025.org/travel-grants/

Meet our speakers! We are pleased to announce the distinguished speakers for HGM2025. See you all at HGM2025! Register Now: hugo-hgm2025.org/registration/ Submit Abstract: hugo-hgm2025.org/abstract-submi… Apply for Travel Grant: hugo-hgm2025.org/travel-grants/

Submit your abstract for the presentation during HGM2025. Abstract submissions will only be accepted electronically through the abstract submission form that will be open until December 14th, 2025. Register Now: hugo-hgm2025.org/registration/ Submit Abstract: hugo-hgm2025.org/abstract-submi…

@ThurstonLab Congratulations!

So thrilled to join the EMBO young investigator programme. Looking forward to some great times ahead for the lab as part of this community.

Early-bird registration is extended until Saturday, December 14th, 2024! Register now for Human Genome Meeting 2025, which will be held in Durban, South Africa on March 11-14, 2025. Don't miss this final opportunity to secure your spot! Register: hugo-hgm2025.org/registration/

Excited to join the Editorial Board of @PLOSBiology, the #PLOS flagship journal in the Life Sciences, that's blazing a trail in support of selective, equitable #OpenScience and reaching global audiences to help advance science faster.