Oliver Cottrell

MBC team has found that anti-progestin therapy could help prevent breast cancer before menopause. Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts. doi.org/10.1038/s41586…

A drug already used on the NHS could one day help prevent breast cancer in women before the menopause who have a family history of breast cancer. In a small study, researchers found it reduced early changes in breast tissue linked to cancer developing. brnw.ch/21wXeFU

Congratulations to our star MRC student @ollie cottrell who defended his PhD thesis on harnessing gene expression oscillations to prevent dormant cancer cells from reactivating. Exciting work that lays the foundation for new ways to prevent relapse.

@Richarding13 @Juvepazzo85 @duthie_marie @Lady__Britannia @RoryStewartUK If you’re genuinely interested in the truth, asking questions and are open to changing your mind: skepticalscience.com/co2-lags-tempe…

@Juvepazzo85 @oliver_cottrell @duthie_marie @Lady__Britannia @RoryStewartUK I support your questions. Most who blindly trott out the climate alarmism, don't know the answers to those basic questions

Can we also please in the maelstrom of our politics not take our eyes of this?

@Juvepazzo85 @Richarding13 @duthie_marie @Lady__Britannia @RoryStewartUK High CO2 raises temperatures, that is irrefutable. And as our friend pointed out, higher temperature may induce CO2 rises. Which in turn raises CO2 and so on and so forth. There’s your runaway effect.

@oliver_cottrell @Richarding13 @duthie_marie @Lady__Britannia @RoryStewartUK What’s your actual point ?

@Richarding13 @Juvepazzo85 @duthie_marie @Lady__Britannia @RoryStewartUK I see.

@oliver_cottrell @Juvepazzo85 @duthie_marie @Lady__Britannia @RoryStewartUK Err, No

@Richarding13 @Juvepazzo85 @duthie_marie @Lady__Britannia @RoryStewartUK And that, my friend, is the basis of your runaway greenhouse effect.

@Juvepazzo85 @duthie_marie @Lady__Britannia @RoryStewartUK Great questions to which I know the answers. However, does @duthie_marie ? Also, there is strong evidence to suggest that raised co2 occurs AFTER raised temperature.

@RestIsPolitics @RoryStewartUK @campbellclaret Would you be intersted in discussing Bulgarian elections next week (7th since 2021)? Catastrophic breakdown in functional democracy. Broken proportional representation. Lots of Russian influence. What happens when a country wants to be democratic and just can't seem to manage it?

🚨 QUESTIONS REQUEST 🚨 What would you like to ask @RoryStewartUK + @campbellclaret? Domestic or international, timely or timeless - reply with your questions below 👇

@RestIsPolitics @RoryStewartUK @campbellclaret Would you be intersted in discussing Bulgarian elections next week (7th since 2021)? Catastrophic breakdown in functional democracy. Broken proportional representation. Lots of Russian influence. What happens when a country wants to be democratic and just can't seem to manage it?

Could Russia interfere in the US election? New podcast out today 💥 This week @RoryStewartUK and @campbellclaret discuss: 🇺🇸 Going into the final weeks of the US election 🏥 Labour's vision for the NHS 🌍 Will the killing of the Hamas leader change the course of the war in Gaza? Listen now - links in the reply 👇

@ChrisMartzWX Using the top 28 + Milton 6 in the last 7 years = 0.86 strong hurricanes/yr (1 every 1.2 yrs) 23 between 1851-2016 = 0.13 strong hurricanes/year (1 every 7.7 yrs) It’s a short observation period for now but in line with other trends outside FL, across the globe - worrying. No?

YOUR CAPS LOCK IS ON. 🔒 Here are some Florida hurricane facts for you. 📚 ➊ Seven of the top 10 strongest hurricanes [by their central mean sea-level pressure, or MSLP] to make landfall in Florida occurred over 30-years ago. Six of those struck either in or before 1960. Three of the top five hit prior to 1940, including the most intense, which was “Labor Day” (1935) at 892 hPa. Here's a link to the data for that, 🫳 🔗aoml.noaa.gov/hrd/hurdat/All… ➋ Florida has been directly hit by 111 hurricanes since 1851, including 40 major hurricanes. Three hurricanes have struck this year alone, but that also occurred in 1871, 1886, 1964, 2004 and 2005. Between Hurricane Wilma (2005) and Hurricane Hermine (2016), Florida went 10-years, 10-months and 15-days without even a single hurricane strike, the longest stretch on record since 1851. ➌ Florida was struck by twelve hurricanes during the 1870s alone, followed by ten each in the 1880 and in the 1940s. How'd that happen? ➍ This isn't the first time that Florida has been struck by two major hurricanes within a short period of time. In 1950, Hurricane Easy (C3) and Hurricane King (C4) struck six weeks apart. And, 20-years ago in 2004, a total of three hurricanes struck within a period of six weeks, including two majors. They were Hurricane Charley (C4), Frances (C2) and Jeanne (C3), the latter two of which struck three weeks apart. Here are the links to those maps, 🫳 🔗#map=4.11/31.46/-78.4&search=eyJzZWFyY2hTdHJpbmciOiJOb3J0aCBBdGxhbnRpYyBPY2VhbiBCYXNpbiIsInNlYXJjaFR5cGUiOiJiYXNpbiIsImNhdGVnb3JpZXMiOlsiSDUiLCJINCIsIkgzIiwiSDIiLCJIMSJdLCJ5ZWFycyI6WyIxOTUwIl0sIm1vbnRocyI6W10sImVuc28iOltdLCJwcmVzc3VyZSI6eyJyYW5nZSI6WzAsMTAzMF0sImluY2x1ZGVVbmtub3duUHJlc3N1cmUiOnRydWV9LCJidWZmZXJVbml0IjpbIk1pbGVzIl0sInNvcnRTZWxlY3Rpb24iOnsidmFsdWUiOiJ5ZWFyc19uZXdlc3QiLCJsYWJlbCI6IlllYXIgKE5ld2VzdCkifSwiYXBwbHlUb0FPSSI6ZmFsc2UsImlzU3Rvcm1MYWJlbHNWaXNpYmxlIjp0cnVlfQ==" target="_blank" rel="nofollow noopener">coast.noaa.gov/hurricanes/#ma… 🔗#map=4.11/31.46/-78.4&search=eyJzZWFyY2hTdHJpbmciOiJOb3J0aCBBdGxhbnRpYyBPY2VhbiBCYXNpbiIsInNlYXJjaFR5cGUiOiJiYXNpbiIsImNhdGVnb3JpZXMiOlsiSDUiLCJINCIsIkgzIiwiSDIiLCJIMSJdLCJ5ZWFycyI6WyIyMDA0Il0sIm1vbnRocyI6W10sImVuc28iOltdLCJwcmVzc3VyZSI6eyJyYW5nZSI6WzAsMTAzMF0sImluY2x1ZGVVbmtub3duUHJlc3N1cmUiOnRydWV9LCJidWZmZXJVbml0IjpbIk1pbGVzIl0sInNvcnRTZWxlY3Rpb24iOnsidmFsdWUiOiJ5ZWFyc19uZXdlc3QiLCJsYWJlbCI6IlllYXIgKE5ld2VzdCkifSwiYXBwbHlUb0FPSSI6ZmFsc2UsImlzU3Rvcm1MYWJlbHNWaXNpYmxlIjp0cnVlfQ==" target="_blank" rel="nofollow noopener">coast.noaa.gov/hurricanes/#ma… Hurricanes are more catastrophic because there is a much larger waterfront population today than there was a century, or heck, even 40-years ago.

@ChrisMartzWX @RonDeSantis 6.4x more common in the last 7 year period than previous baseline.

@ChrisMartzWX @RonDeSantis Using the top 28 + Milton 6 in the last 7 years = 0.86 strong hurricanes/yr (1 every 1.2 yrs) 23 between 1851-2016 = 0.13 strong hurricanes/year (1 every 7.7 yrs) It’s still a relatively short observation period and I’ve not done the stats - but that is a concerning trend.

Governor @RonDeSantis shot down a news reporter today who tried to get him to blame Hurricane Milton on climate change. He didn’t evade it either — he directly answered the question and cited stats to debunk the claim. Oh, and those stats Governor DeSantis cited? They were directly from my analysis of NOAA HURDAT2 data this morning. Trump and Vance should take a page out of his book and sack reporters with data and leave them speechless.

@JohnOBrennan2 Though, now we’re here, not sure we should be over-politicising or otherwise criticising a simple show of connection to local fans. Dislike both Novak’s views and Bulgarian division/nationalism. But he’s just singing a nice song at a charity match. No?

@JohnOBrennan2 Was not a criticism or commentary of your post or its sentiments. Was supplementing correct context for others who may encounter the post via your tweet.

Oh please. A Serbian ultra nationalist milks the crowd? No thanks. Bulgaria has had its fill of divisive nationalist idiocy.

Our innovative study brings out the distinction between single cell and population-level #dynamic regulation. Single cell #oscillators can behave abnormally, despite this the population is normal due to cell #coupling mediated compensation. @Dev_journal journals.biologists.com/dev/article/15…

Had a great time in Germany @embl for #EESBioOsc - hearing about all things oscillations across a dizzying range of scales and contexts. Enjoyed giving a talk on my PhD work with @PapalopuluLab @RobClarkeLab on Hes1 oscillations in breast cancer.

Happy to have contributed to investigation of circadian clocks in breast cancer with Shiyang Li in Qing Jun Meng's lab funded by a collaborative @BreastCancerNow grant with Sacha Howell in @MCRBreastCentre @MCRCnews and @UoM_DCS pnas.org/doi/epdf/10.10…

How do cells decode #TF oscillations and how does this impact development? We find #NGN3 protein oscillates in #pancreatic endocrine cells, #oscillations are likely decoded via fold-change and impact on the timing of differentiation, but not fate choice: papers.ssrn.com/sol3/papers.cf…

How many genes oscillate? In our latest paper we ask this question in #Glioblastoma. Using #bioinformatics and the #osconet algorithm we identified candidate genes and then experimentally validated that #SOX2 oscillates. Now in Press biorxiv.org/content/10.110…