balaji jegannathan

NCCN Tumor Boards - Exploring Omission of Radiation Therapy in the Manag... youtu.be/DdILenW5YiQ?si… via @YouTube

Effect of conization, manipulator use, and their interaction on recurrence after radical hysterectomy for cervical cancer: A multicenter retrospective analysis - Gynecologic Oncology gynecologiconcology-online.net/article/S0090-…

CAR-T without manufacturing? A new Nature highlight shows we may soon generate CAR-T cells directly inside the body 🧬 ⚙️ In vivo CRISPR strategy • EDV → delivers Cas9 + gRNA to T cells • AAV → delivers CAR template • Targeted insertion into TRAC locus 📊 What they saw (mouse models) • 5–20% of T cells became CAR+ in ~2 weeks • Robust CD19+ B-cell depletion • Leukemia models → complete responses across treated mice 💡 Why this matters • Removes ex vivo manufacturing bottleneck • Moves toward off-the-shelf CAR-T • Potential to scale cell therapy globally 🌍 ⚠️ But still early • Preclinical only • Off-target editing + safety concerns • Human efficacy remains uncertain 🎯 Takeaway We may be entering the era of 👉 “in vivo programmed CAR-T” A potential paradigm shift in cell therapy delivery. 📖 Full paper in comment ⬇️ #OncoTwitter #MedTwitter #CART #Immunotherapy #CRISPR @OncoAlert @myesmo @esmo_open @asco @larvol

🚨 Physical Activity and Cancer Mortality in Survivors. Pooled analysis of 6 cohorts (n=17,141) shows post-diagnosis moderate to vigorous physical activity is associated with lower cancer mortality across several cancers. Even low activity levels reduced mortality in bladder (HR 0.67), endometrial (HR 0.62), and lung cancer (HR 0.56). Meeting activity guidelines after diagnosis improved outcomes in lung (HR 0.58) and rectal cancer (HR 0.51), even in previously inactive patients. 📖 @JAMA_current DOI 👉🏻 doi.org/10.1001/jamane… #CánCare #Oncology #CancerSurvivorship #PhysicalActivity #LungCancer

They Could've Changed The World #realtalk #inventions #facts #tr... youtube.com/shorts/Z7HU-UB… via @YouTube

New in #practicalRO: Three-Step Image Guidance Strategy for Rectal Anterior Wall Margin Reduction in Hypofractionated Prostate Radiation Therapy #radonc tinyurl.com/proyangao

🫁 Emerging Biomarkers for Immunotherapy in NSCLC. PD-L1 and TMB remain imperfect predictors of response to ICIs in NSCLC. Emerging biomarkers include genomic alterations (KEAP1, STK11, SMARCA4), tumor-infiltrating lymphocytes, metabolic pathways (IDO, adenosine), and blood-based markers such as ctDNA and inflammatory signatures. AI-driven composite models may improve prediction. 📖 ImmunoTargets and Therapy DOI: doi.org/10.2147/ITT.S5… #CánCare #NSCLC #lungcancer #immunotherapy #biomarkers

Yes! The answer is yes.

This is one of the best pieces I’ve read in a long time. Many thanks to @anish_koka for this superb piece and thoughtful recounting. Those who really know @VPrasadMDMPH know he will do even more good and rise even higher.

NCCN Guidelines® Insights: Rectal Cancer, Version 3.2024 doi.org/10.6004/jnccn.…

Today I learnt how to safely give Nivolumab + Ipilimumab 👇 • No routine premedication • Sequence matters: Nivo → Flush → Ipi • Correct dilution: Nivo 40 mg/40 mL, Ipi 50 mg/50 mL • Each infusion 30 min Simple rule, safer administration. #MVOnco #Oncology

Watch “NEJMdo007738” on #Vimeo vimeo.com/1068544899?fe=…

👉How do we combine #TKIs with various forms of #radiotherapy in #NSCLC? When should we interrupt or modify their dose? 💡Just out in @ESMO_Open a collaborative effort between @myESMO and @estro with recommendations for #EGFR, #ALK and #BRAF/MEK inhinitors Happy to have contributed to this practical guide for clinicians Link to the article: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… #LCSM @IASLC @ASCO @OncoAlert @OncBrothers @oncodaily @MedscapeOnc @VJOncology @Peerview @EGFRResisters @EgfrUk @EGFRmNSCLC @YoungLungCancer @ALKPositiveinc

Papillary RCC is not one disease. What matters most? Biology. • FH-deficient • MET-driven • Classic • MiT translocation Most patients → ICI + TKI backbone. Treat the mutation. Not just the morphology. #RCC #KidneyCancer #PrecisionOncology #MVOnco