पारश

@Tesla is the new @Apple. Change my Mind.

@uttambajra78742 Aba tapai rajinama dinus 😂

घर को गृहमंत्री लाई राजीनामा दे भने को उल्टो तेरो पोल खोलू रे

@Ronalfa @russianblue2009 @SOUJIJP You are doing a great job. 👏 Hope one day I could meet you in person.

@parash061 @russianblue2009 @SOUJIJP Achievement unlocked!

創薬の世界で、これまでの常識を根底から覆す驚異的なニュースが入ってきました。バイオAI企業のNoetikが、治験で「失敗」した抗がん剤の95%は実は有効であり、AIを活用することで救済できるとの確信を示しています。 製薬ビジネスは、1つの薬を世に出すまでに10年以上の歳月と数千億円の費用を投じる、極めてリスクの高い産業です。しかし、多くの有望な薬が最終段階の治験で「期待したほどの平均的な効果が出なかった」として捨てられてきました。Noetikはこの現状を「薬のせいではなく、適切な患者に投与されていなかっただけだ」と鋭く指摘しています。 彼らが開発した「TARIO-2」というAIモデルは、画期的です。がん患者が日常的な検査ですでに受けている「標準的な組織切片標本」から、約1万9000もの遺伝子の空間的な広がりを予測し、腫瘍のマップを作り出します。これにより、その薬が本当に効くはずの「隠れた対象者」を、かつてない精度で特定できるようになったのです。 この主張を「単なる夢物語」と切り捨てることはできません。世界的な製薬大手であるGSK（グラクソ・スミスクライン）はすでに、肺がんと大腸がんを対象に、5年間で5000万ドル規模のライセンス契約を締結しました。保守的な巨大資本がこれほどの投資を行う事実は、AIによる「敗者復活」がすでに実務のフェーズに入っていることを証明しています。 もし、これまで「効果なし」とされた薬たちがAIの目利きによって蘇れば、創薬コストは劇的に下がり、より多くの患者に個別最適化された治療が届くことになります。これまで「治らない」とされていたがんに、かつて見捨てられた薬が特効薬として届く。そんな未来が、AIの力で現実のものになろうとしています。 最先端のテクノロジーは、過去の失敗さえも資産に変えてしまう。私たちは今、医療の歴史における大きな転換点に立ち会っているのかもしれません。

Converting bits to atoms.

@elon when?

@swarsirohiya Convert Kantipur to AI training infra

I used to think Nepal’s capital markets had the most creative “artists” some of the financial structuring is next-level. But after SPACs and now with Allbirds pivot from shoes to selling off their business and pivoting into AI infra, I might have to admit they’re giving NEPSE “artists” some global competition. Either ways, my favorite footwear pivoting to my favorite sector. I’m okay 🙂

@nepali_investor Definitely, games can go global.

@parash061 TBH service apps for Nepalese customers - I don't see as much opportunity! 1. low purchasing power 2. sclaing issue (in comparision to games) 3. limited exit opportunites 4. issue with luring international investments Doesn't mean we don't need em,

AI is all cool, but a country like Nepal should really focus on games. This game made by 6 developers and overall 20 person team got investment of over $1B. I myself have scaled a game to 100m+ downloads in 6 months (not low margin Ludo game which takes hundreds of years).

🚨🚨🚨 RASOLUTE-302 Ph3 is POSITIVE "Daraxonrasib demonstrated a median OS of 13.2 months versus 6.7 months for chemotherapy, with a hazard ratio of 0.40 (p < 0.0001)".... WOW! AMAZING news for patients with #PancreaticCancer The RAS Revolution is ON!! ir.revmed.com/news-releases/…

@Aiims1742 Extraordinary results!!!

@Iampluripotent Yo DDA le herdaina ra?

डाक्टर एउटा औषधि लेख्दा फार्मेसीवालाले आफ्नो हिसाबले औषधि दिन्छन्। एकपटक चक्कर लागेको बिरामीलाई दिन cinnarizine लेखेको फार्मेसीले एलर्जीको लागि दिने cetirizine दिएर पठाएका छन्। औषधिको नाम उस्तैउस्तै भए पनि काम एकदम फरक! यस्तो केसको जिम्मेवारी कसले लिने?यस्तो बेथिति कसले रोक्ने?

India government is supporting 12 labs to build AI models, what is our Nepal government doing to support AI model training by local labs? @PM_nepal_

@PurnaAdh This is a great initiative. How to get involved?

Nepali Diaspora Portal : विश्वभरका नेपालीका लागि एकीकृत डिजिटल पूर्वाधार Dr. Hemaraj Sharma NRNA president Knows these facts and he is committed to his vision. He and the team declares on 26 points agendas it leads to the following! Nepali Digital Portal केवल एउटा वेबसाइट होइन—यो विश्वभर छरिएका नेपालीहरूको डिजिटल अर्थतन्त्र, नेटवर्क र अवसरलाई एकीकृत गर्ने Operating System हो। ९० भन्दा बढी देशमा रहेका नेपाली, दूतावास, कन्सुलेट, विज्ञ, व्यवसायी, लगानीकर्ता र युवालाई एउटै प्लेटफर्ममा जोड्ने दूरदर्शी पहल।- - लगानीको दृष्टिकोणबाट Nepali Diaspora किन महत्त्वपूर्ण? आजसम्म NRN पूँजी, ज्ञान र अनुभव छरिएको अवस्थामा छ। Nepali Diaspora ले यसलाई संगठित गर्दै: -नेपालमा लगानीका अवसरहरूको एकीकृत डिजिटल पोर्टल (sector-wise: ऊर्जा, पर्यटन, IT, कृषि, पूर्वाधार) -Verified projects र policy clarity सहित सुरक्षित लगानी वातावरण -Diaspora investors, entrepreneurs र startups बीच direct matching system -Expert pool मार्फत technical support, advisory र mentorship -Cross-border partnership र co-investment platform -Legal, banking, property र regulatory support एकै ठाउँमा -अन्य मुख्य सुविधाहरू: -NRN citizenship, ID, visa, driving license लगायतका सेवा समाधान -Country-wise र city-wise digital network (जस्तै USA का state र city स्तरसम्म) -Embassy र consulate सँग direct digital integration -Knowledge base, case tracking र policy updates -Global Nepali forum—समस्या समाधान र सहकार्यका लागि -दीर्घकालीन प्रभाव: NepalOS ले -NRN पूँजीलाई उत्पादनशील क्षेत्रमा रूपान्तरण गर्ने -Brain drain लाई brain circulation मा बदल्ने -नेपाल र विश्वभरका नेपालीबीच स्थायी डिजिटल पुल निर्माण गर्ने -आर्थिक विकास, रोजगारी र नवप्रवर्तनलाई तीव्र बनाउने अब समय आएको छ— विश्वभरका नेपालीको शक्ति (Capital + Knowledge + Network) लाई नेपाल निर्माणमा एकीकृत गर्ने। -Nepal looking overseas : One Digital Home | One Invest Nepal looking overseas विश्वभरका नेपालीलाई जोड्ने डिजिटल पूर्वाधार। सेवा मात्र होइन—NRN पूँजी, सीप र नेटवर्कलाई नेपालमा लगानी र विकाससँग जोड्ने gateway। ९०+ देशका नेपाली एउटै प्लेटफर्ममा—अवसर, सहकार्य र समाधान एकै ठाउँमा। अब Global Nepali शक्ति Digital बाट आर्थिक रूपान्त

@Vritrax__ Can you so the air particles ppm levels? Is there real time air particulate matter geospatial info for Nepal available?

Another cool project I’ve been working on is a geospatial monitoring system for Nepal that supports damage assessment, deforestation monitoring, and illegal sand mining detection. I’m still exploring its use cases and whether I can integrate it into my NEPSE trading engine.

In 2003, after a thorough study of the Mahabharata, Giampaolo Thomasetti began work on a large-scale project dedicated to it. After 12 years, he completed his collection of over 20 majestic paintings depicting the main moments of this great spiritual epic. 👇

@VictorPaudelx Good to see you here. Keep up the good deed. Also, be transparent. What are your conflicts of interest. Please disclose. How are you personally benefiting from your relationship with PM?

Every help counts. Please spread the word.

@TheBiddhut Done, wish for speedy recovery.

भर्खरै पढ्न आएकी एकजना नानी Leukemia भएर अस्पतालमा छिन्, सहयोग गरौँ है। gofund.me/e5e06f90f

Congrats to Denali for their FDA Approval of AVLAYAH! Fun bit of biotech history. The bi-specific shuttle technology used in Avlayah came from F-star, a European biotech we helped seed in 2006 (thx Regina Hodits). They were advancing a bi-specific mAb format for a range of uses. Image below is from their 2006 pitch to us. F-star did a collaboration with Denali to use their "Fcab" technology for BBB shuttles in 2016, when the now 10-year old biotech was figuring out what programs to advance internally vs in collaboration nature.com/articles/d4374… In 2018, seeing momentum in their BBB programs, Denali acquired the subsidiary housing the BBB technology, called F-star Gamma. fiercebiotech.com/biotech/denali… With the approval of Avlayah, F-star's original technology thesis finally made it to market for one of the many postulated uses... 20 years later... Atlas Fund VII, a 2005 vintage fund, will be getting a small but fun milestone payment for approval... Biotech is a long game, played by teams across the ecosystem collaborating in different ways over decades. Huge kudos to Ryan Watts, @rtnarch, and the team at Denali for their persistence in pushing Avlayah forward to patients.

Congratulations @AnupKaphle for the new role. Can we get a dedicated science and technology column in TKP? Something like breakthroughs of a week. Can help, if needed.