Jesse Passler, PhD, ABPP-CN

@hjluks In your opinion what’s the best intensity pattern for aerobic fitness?

I hear this every week in my office: "Doc, my heart rate hits 150 during squats — that's cardio, right?" No. And if your cardiologist hasn't explained why, keep reading. 🧵

@JasonFitz1 @Alan_Couzens @JohnGoldman I just finished it.

@passlerjs @Alan_Couzens @JohnGoldman Did you listen to the episode?

A 50-year-old athlete trying to drop ~2 hours off his marathon PR & qualify for Boston... in one year?! As I told him... “It’s not impossible… it’s just unreasonable.” 😊 @JohnGoldman outlines the strategy in detail for @JasonFitz1 : • Build a monster aerobic base • Exercise ruthless patience • Fix the biggest limiter • Assemble a fully committed support team That’s #ProjectUnreasonable ! Listen in for all the gory details. As per usual, John holds nothing back! 🎧 podcasts.apple.com/us/podcast/fro…

Early specialization is overrated. Generalists excel over time. Data on >34k stars in sports, music, science, and chess: Focusing on a single field predicts a faster rise, but cross-training foreshadows a higher peak. The most successful adults start off as well-rounded kids.

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵

“I've suffered a great many catastrophes in my life. Most of them never happened.” -Mark Twain

@andyholloway I traded him to my week one opponent before this latest update. WHAT A MOVE!

We'll see what happens. I'm not a doctor. But I'd put odds of CMC on the field Sunday at less than 25% after that presser.

In patients with treatment-resistant #depression, combining esketamine with an SNRI results in lower rates of mortality, hospitalization, and depression relapse. ja.ma/45HBnQW

Most viewed this week from @JAMAPsych: ADHD medications are consistently associated with reduced risks of self-harm, unintentional injury, traffic crashes, and crime, but these protective effects weakened as prescription rates increased. ja.ma/3ISDpV5

In older adults, discontinuing antipsychotic medications after hospitalization was associated with reduced risks of rehospitalization, falls, infections, delirium, and mortality compared to continuation. ja.ma/40y37nO

Systematic review and meta-analysis: Stopping antidepressants leads to slight symptom increases compared to placebo, but these symptoms are not clinically significant and do not include mood changes. ja.ma/4lNdBIu

The fact that he took his name and lived his morals will always mean something to me.

Pope Francis was remarkable. Even though I would not describe myself as a Christian, my mother’s side of my family was Catholic. She was a lover and rescuer of animals and I was raised to revere St. Francis (1/2)

Happy to become a board certified neuropsychologist today. Thank you to all my mentors and colleagues including the great @DocBlock_neuro !

🚨Interesting article alert🚨 Schretlen, Finley, Del Bene, and Varvaris just published a paper reviewing meta-analysis of #cognitive functioning across 94 health conditions (CNS and non-CNS). academic.oup.com/acn/advance-ar…

Happy to share that our work applying precision mapping to individuals with depression sampled longitudinally over an extended period has been published this week in @nature. Brief recap of the main findings and their potential implications below. nature.com/articles/s4158…

Many mental-health conditions have bodily triggers economist.com/science-and-te… from @TheEconomist

Here is a data-driven reorganization of the symptoms in the DSM-5. 🧵1/10

This is a map of repetition among all symptoms in the DSM-5. 🧵1/10

🚨🚨🚨 New FND Treatment 🧵 This patient’s FND was triggered by a dog bite to her R thigh. She developed R leg heaviness that progressed to a severe tremor during a soccer game & intermittent head/trunk movements when walking. /1 #PTtwitter #medtwitter #neurotwitter #FNDaware