Pepguide AI
32 posts
Pepguide AI
@pepguide
Everyone's talking about peptides. Finally, a place that makes sense of them.
Florida, USA Katılım Haziran 2025
1 Takip Edilen36 Takipçiler
Everyone is blown away by the new retatrutide trials.
Frankly, I’m not.
Yes, we’re seeing more total weight loss than tirzepatide.
But more total weight loss does NOT automatically mean better body composition.
And until we see the full DEXA scans, one of the most interesting metrics is this:
👉 pounds lost per inch off the waist.
Why?
Because if someone is losing dramatically more scale weight without proportionally more waist reduction, some of that extra loss may be coming from lean mass.
Here’s what’s interesting:
Tirzepatide 5mg:
• ~35 lbs lost
• ~5.7 inches off waist
• ~6.1 lbs lost per inch
Retatrutide 4mg:
• ~47 lbs lost
• ~6.4 inches off waist
• ~7.4 lbs lost per inch
So with retatrutide, you’re losing more total weight per inch off the waist.
And even the highest dose of tirzepatide appears to be more muscle sparing than lowest dose of Reta. 6.7 lbs per inch vs. 7.4 per inch
So Reta for physique optimization?
Worse.
The goal isn’t just becoming lighter. The goal is becoming leaner while keeping the physique powerful, athletic, and dense.
Max Marchione@maxmarchione
Retatrutide phase 3 obesity trial just came out and the results are genuinely insane: - 28.3% bodyweight lost on 12mg over 80 weeks - 70.3 pounds on avg. or 31.9 kg - 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory) - 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients - 65.3% of 12mg patients dropped below the obesity BMI threshold - 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%) - significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP - no cardiac or liver signals Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.
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@cremieuxrecueil Mostly good take. People with obesity should take Tirz. It’s already approved and does not increase RHR like Reta does.
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Now that we have phase-3 results for retatrutide, it's time to revisit the question:
What would happen to obesity if we gave every obese (BMI 30+) person the drug for just one year?
Well, the obesity rate would fall by more than 80%! We'd be skinnier than the U.S. circa 1980!
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@morellifit Genuinely curious of your thoughts on my take below.
Tirz for medically Obese people
Reta for everyone else
x.com/pepguide/statu…
Pepguide AI@pepguide
@stackapp @maxmarchione Yeah my pov is that Tirz is phenomenal for anyone medically classified as obese (BMI of 30+), Reta is great for everyone else. My friend (F37) went from 140 to 120 in two months on Reta and never titrated to over 2mg/week (split dose). Currently on maintenance @ 1mg/wk.
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I'm going through the retatrutide phase 3 data, and the cardiometabolic numbers are more interesting than the weight loss:
- 24.1 cm off the waist on 12mg (9.5 inches)
- significant drops in systolic blood pressure
- triglycerides down
- non-HDL cholesterol down
- hsCRP down (a key marker of inflammation)
I'm giving it a few years before people realize GLP-1s are more than just weight loss drugs.
Real Peptides@realpeptides
Retatrutide phase 3 obesity trial results are out, and it's safe to say that this is the next generation of obesity medicine: - 28.3% bodyweight lost on 12mg over 80 weeks (70.3 lbs) - 30.3% at 104 weeks in higher-BMI patients (85 lbs) - 45.3% of patients hit 30%+ weight loss - 65.3% dropped below the obesity BMI threshold - notable drops in blood pressure, triglycerides, cholesterol & inflammation - no cardiac or liver signals For those of you who are new to peptides, the reason retatrutide works better than semaglutide and tirzepatide is its mechanism. Semaglutide hits one hormone, tirzepatide hits two, but retatrutide hits three: GLP-1, GIP, and glucagon. Glucagon increases the amount of energy your body burns at rest so you eat less and burn more at the same time. Retatrutide is the drug that has the potential to end the obesity pandemic.
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@stackapp @maxmarchione Yeah my pov is that Tirz is phenomenal for anyone medically classified as obese (BMI of 30+), Reta is great for everyone else.
My friend (F37) went from 140 to 120 in two months on Reta and never titrated to over 2mg/week (split dose). Currently on maintenance @ 1mg/wk.
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Retatrutide phase 3 obesity trial just came out and the results are genuinely insane:
- 28.3% bodyweight lost on 12mg over 80 weeks
- 70.3 pounds on avg. or 31.9 kg
- 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory)
- 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients
- 65.3% of 12mg patients dropped below the obesity BMI threshold
- 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%)
- significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP
- no cardiac or liver signals
Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.
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@stackapp @maxmarchione Assuming you’re saying this because Tirz does not increase resting heart rate like Reta does? I agree if so (and have had more success with Tirz than Reta)
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@maxmarchione It will do well, but most Drs will prescribe Tirz over Reta
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Top 3 Peptides and it’s not even close:
1.) Retatrutide
2.) BPC-157
3.) MOTS-c
If someone said you can only have 3 these are it, if someone said you can only have one, that is my list in order...
How about you? Top 3 in order?
-B
CryptoDaddi@TheCryptoDaddi
Top 3 Peptides and it’s not even close: 1.) Retatrutide 2.) BPC-157 3.) MOTS-c
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@DaBoomBoomBilly @pepfessions Yeah. “Maybe 3rd” is a good policy. If yall don’t hear from me again it was a bad batch.
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@pepguide @pepfessions ive seen some placing offering it. i try to not be the 1st to try something new.. or the 2nd. MAYBE 3rd but thats pushing it lol.. 350 from uther?
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i own a big peptide brand and this industry is crazy, Reta costs less than 10 cents per mg
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@DaBoomBoomBilly @pepfessions Good luck, that’s a steal! I concede. You obviously have the 🔌 to my suppliers supplier lol. Any eyes on Eloralintide? About to drop $350 on a kit of 10s.
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@pepguide @pepfessions i got details on a R30 for $99 coming soon, but its from someone that did some scams in the beginning, but apparently went legit.. but still kinda risky. maybe like 1 kit just to see lol
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@DaBoomBoomBilly @pepfessions Fair. Totally fair. Thank you for the info. 🤝
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@pepguide @pepfessions aye ✋🤚 no harm no foul. i was just matching energy for energy. they also had an R100 sale from uther right before that. those amounts are mostly always custom batches and often times you can pick from either 3ml vials or 5ml for ease of reconstitution
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@DaBoomBoomBilly @pepfessions Not new. Not scamming. Never heard of R140. I stand corrected.
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@pepguide @pepfessions man you must be new at this and just trying to scam a few bucks off people.
this one was from the WildWhite group. sourced it from biochemAPI. a custom batch they had produced and the sale just ended in april.
would you like me to send you direct links too?
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@pepfessions @DaBoomBoomBilly I’m waiting for proof so I can jump in on the next gb of this mysteriously under priced and over filled vendor.
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@pepguide @DaBoomBoomBilly Im just eating popcorn watching this unfold, getting heated
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@DaBoomBoomBilly @pepfessions And who is taking 14mg/wk , ten weeks is a streeeeetch for Reta lol
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@pepguide @pepfessions yes math is important. so is knowledge about peptides if you are going to make a shitty ai app.
yes r140 means 140mg per vial. and a kit is 10 vials. that is the lingo in this space since you dont know.
10 x 140mg = 1,400mg
$320/1,400mg = $0.2285/mg
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@mattagins @pepfessions $200 / 500mg =$0.4/mg
HX is still cheaper.
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@DaBoomBoomBilly @pepfessions What is r140? Are you saying 140mg per vial?
R60 is 10 x 60mg =600 mg
600 x .3 = $180
Math is important friend.
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@pepguide @pepfessions i found r140 kits at $320 in about 3 clicks just now. still not 10 cents but better than what you've found
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@PeptidePartners Curious about this, have you ever seen decay?
***Me eyeing the ten years worth of Reta in my freezer. ***
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👍Occasionally, we have batches re-certified to make sure our long-term storage is working as intended. Our BPC batch was initially certified 2 months ago, so we sent out 5 more randomly sampled vials for certification last week.
March vs May. Everything is on point. No decay.
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Reminder: a peptide can be 99% pure AND 42% short on actual dose. Different scam, same outcome for the buyer.
Today's example: Skye Peptides IGF-LR3.
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