John (Jack) Plumley

Just learned Sonny Rollins passed away a day ago "Sonny could play any tune like he wrote it” We all write the script to our own lives; Sonny was 95 years old, and what a life he lived Through his music, his legacy, his personality, his words, he will live on Thats Jazz, baby

@bryan_johnson this aint it fam

First, GLP-1s. Now this. Others will soon follow. Don’t Die is the sunrise on the horizon.

@Pedalo1979 @OfTheBraveUSA cavemen were smart

@OfTheBraveUSA At least he is honest on that part… Hegseth is the epitome of solving issues with violence, agression, attacks, … basically an underdeveloped brain close to that one of a caveman…

Donald Trump: "The Secretary of War Pete Hegseth…He loves war." American troops and their families deserve a Defense Secretary that works to prevent war, not one who relishes in it.

@OfTheBraveUSA funny line tho, war is sick, why not poke fun at the depravity of it?

@Martyupnorth nope--my grandparents did often though

Have you ever taken a train in Canada?

The 2026 Biohacking Conference in Austin: An Insider’s Guide to What to Expect open.substack.com/pub/jackplumle…

Sometimes you wonder why all of the great experiences have occurred already Like the prime of jazz in the 50s Or the pinnacle of rock music in the early 70s

Arthur C. Clarke wrote that any sufficiently advanced technology is indistinguishable from magic IMO wearable sleep trackers are precisely the kind of technology that illustrates this point and are in near everyday, commonplace use

What was melatonin's role before we slept? Meaning, in our ancient Eukaryotic ancestor, that operated fundamentally different than anything we recognize as life today.

@bryan_johnson @_katetolo N-of-1 is the future we all need

We now have a female Bryan Johnson. It’s Kate Tolo. She will become the most measured female in history. +$2 million of spend per year + Developing a female-specific protocol + Sharing everything for free To start, she will spend 3 months mapping her baseline. Men, in contrast, can get their baseline done in 1 or 2 weeks. + 3 months for baseline measurement + across 4 time points per cycle + doing the same thing every day + a dedicated full-time medical team For context on the extensiveness of measurement, during the past 5 years, we’ve collected 1.5 billion data points on my body. I suspect Kate will exceed that given technology has improved since I started. The goal is to create a repeatable waveform of hundreds of life-critical biomarkers. Once the baseline is acquired, she will begin interventions. We will try to answer practically useful questions and share all of the data + learnings for free. Can fertility be improved? + Should women cold plunge? + Can PMS symptoms be alleviated? + What should a female sauna protocol be? + Should dosage change throughout the month? + What keeps a cycle regular? + Does the body need more iron, magnesium, or protein at specific phases? + Should women fast? + Should recovery protocol change by phase? + What's the earliest detectable signal of perimenopause? + Can perimenopause be slowed? + How is cognitive load & mood affected? + Does stress impact men and women the same? Kate has suspected endometriosis. 10% of all women do. We will try to tackle this too. I am excited for all of the surprising things we will hopefully uncover. Unlike me, Kate does not have the innate desire to wake up at 4:30am and do six hours of longevity therapies. She’s the cofounder of Blueprint, building in the trenches with me since day one. She understands the game and how hard it is. In many ways, this is a sacrifice for her. She is a creative person, going from a life of freedom and spontaneity to a rigid protocol. Traditionally, RCTs have been viewed as the gold standard. But RCTs have underserved women. The FDA banned women from clinical trials for 16 years (1977 to 1993), and most "medicine for women" is still medicine tested in men. Demanding RCT-only evidence for women's health is demanding evidence that doesn't exist. There is not enough practical scientific literature for women to reference only RCTs. It leaves half the population without a path to know what to do. N=1 medicine is gaining ground and picking up where RCTs specifically fail. Individual science experiments give us signals that answer what to do on a day-to-day basis. This is even more important for women. If you’re new to Kate and my world, I want you to understand that we have your back. Our intentions are to be a sturdy, reliable force in your life. To care for your best interest as we’d care for our own. We want what’s best for you and our loyalty is to your existence. It’s pretty cool to be living in a time when we may be the first generation to not die. I’m not suggesting immortality, but lifespans so long that we stop thinking about lifespans. At the end of the day, the one thing we each care about more than anything else is one more breath. I’m proud of Kate for taking on this responsibility. It’s painful, exhausting and costly. The beginning of the world’s first n=2.

a king is the slave of history - Tolstoy

@bryan_johnson The most important thing during a global pandemic, is how to get as rich as possible -- thats my takeaway from 2020

If Hantavirus mutated into a global threat, it would unleash AI + biotech unlike anything we've ever seen. > genome sequenced and public in 4 hours > AlphaFold maps every protein target > AI screens 10,000 drugs in 24 hrs > 50 vaccine candidates designed simultaneously > AI designed antibodies in days > risk of death computed instantly > decentralized trials launch globally > enroll from home > 20 countries manufacturing at once > first doses in three weeks > real-time dose characterization > your genome + biomarkers determine your protocol > variant map updates every hour No one would wait for governments.

@foundmyfitness do a podcast together

Small correction here. You don’t need to reach a core temperature of 102.3°F to activate HSP expression. And you definitely don’t need to sit in a 200°F sauna for 30 minutes. The research shows HSP expression can increase by ~50% after 30 minutes at 163°F, with core body temperature rising to only about 101°F. Sauna benefits (even those related to HSPs) don’t require extreme heat or pushing core temperature that high.

Picasso and Dance. Parade, 1917 youtu.be/_Chq1Ty0nyE?si… via @YouTube

@ericweinstein Eirc, you should really move to a Scandinavian country to be amongst more rational humans

Good thing we’re carefully informing our…[checks notes]…pastors about interdimensional entities w/ exotic propulsion. That way they can comfort scientists who are “big mad” that they have no information about this. It’s not a psy-op…because Jesus. It just makes so much sense!

@rand_longevity as little as $2k Canadian

how much money would you need to receive each month to live comfortably?

an opening oddity

Society was built to make money. Indifferent to your health and sanity. For example, we did not evolve to: + sit 10 hours a day + have our attention fractured 300 times daily + compare ourselves to millions of others + travel 9 time zones in 13 hours + tolerate sounds above 85 dB causing hearing loss + outsmart algorithms hijacking our reward system + breathe fine particulate air pollution + live under 16+ hrs of artificial light a day + have 3 courses of antibiotics before age 2 + eat ultra-processed foods for 60% of daily calories + consume 17 teaspoons of added sugar a day So if you're feeling down in the dumps, maybe fatigued, a little or a lot depressed, anxious, that's why.

The most advanced Urolithin A supplement was launched at Davos too -- is everything relating to this place and the WEF inherently bad?