Marco Preußner

Our most recent work on the “function and evolution” of #nuclear_speckles is now online at Cell @CellCellPress cell.com/cell/fulltext/… Read the thread 👇for the highlights of our findings.

🎉Excited to announce that our paper on the blueprint of the human spliceosome is now out in @ScienceMagazine ! A decade of work with Juan Valcárcel and the incredible team at @CRGenomica to uncover the intricate roles of this essential RNA machinery.science.org/doi/10.1126/sc…

Please check out our new review on commonalities between vesicular and nonvesicular transport via intrinsically disordered proteins! Hope you will like it!

📯 Our work on a new core splicing factor is out in @MolecularCell! FUBP1 is important for splicing of long introns. Multivalent interactions support spliceosome assembly and intron bridging. Great collab with @Sattler_lab & Luck_lab. Check it out here: bit.ly/4552p18

Gene therapy approach to boost 'cold shock protein'€™ in the brain without cooling protects mice against neurodegenerative disease shar.es/afIZjj

Hypothermia in a syringe: Manipulation of RBM3 alternative splicing using antisense RNA therapeutics prevents neurodegeneration at normal temperature. Check our article with @MallucciLab and @OmiqaBio in @EmboMolMed Link: doi.org/10.15252/emmm.…

Now in @ScienceAdvances: Alternative splicing occurs after step 1 of splicing! Also reveals trans-acting factors for NAGNAG splicing. Thanks to Reinhard and his team, my phantastic students ⁦@FUBiochemistry⁩ ⁦@FU_Berlin and help from @OmiqaBio DOI: 10.1126/sciadv.adf1785

Our next RNA club meeting today at 5 pm will feature the research of @pre_mRCO from Heyd lab @FUBiochemistry and Vanessa Loiacono from Bock lab @MPIMP_Potsdam. Join us in person or via zoom!

GGGOOOAAALLL we made the cover! huge thanks to the team @NatureSMB @sarakosman for highlighting our work! #ResearchHighlights" target="_blank" rel="nofollow noopener">nature.com/nsmb/volumes/2… 🤩😍🥰😊🥲 feelin' all the feels 🥲😊🥰😍🤩

Ever wonder what happens to our brains at lower temperatures? Looks like our neurons enjoy a cool bath – thanks to increased expression of a cold-shock protein, RBM3. Check out our preprint sharing some secrets behind RBM3 cold induction. biorxiv.org/content/10.110…

For further mechanistic insights also check another preprint from @JulieQLin, @DeepakKhuperkar, @MallucciLab, @RueppLab and @ule_lab. biorxiv.org/content/10.110…

Can we target alternative splicing to treat neurodegenerative diseases? With @MallucciLab and @OmiqaBio we find that a poison exon is responsible for cold induced RBM3 expression. Targeting this exon by ASO-therapy results in neuroprotection in vivo. biorxiv.org/content/10.110…

Now online @NAR_Open: How a 1°C increase in temperature induces antiviral genes and promotes an immune response! Great work from @_brunalos! doi.org/10.1093/nar/gk…

Here comes the second one from @AlexandraBergf1 . This time also including the great support from Marco (@pre_mRCO) from the lab of Florian Heyd @FUBiochemistry . Happy to be part of this work 🥳 nature.com/articles/s4146…

Are stress granules the RNA analogs of misfolded protein aggregates? Both RNA and proteins can form promiscuous interactions. Similar to the protein chaperones, the RNA chaperones limit self-assembly. #RNASpecialIssue #condensates ➡️bit.ly/32JtPz0

The popularity of selected methods for differential #splicing identification. #bioinformatics #methodsmatter

For the first time, researchers have revealed the atomic structure of the human minor spliceosome, according to a new study in Science. The findings provide a framework for a mechanistic understanding of the function of this ribonucleoprotein complex. ($) fcld.ly/xgmy6w2

Have you noticed it’s getting chilly in the air? How are plants coping with this? Happy to share the remarkable work of David Guillaume-Schöpfer, who did his PhD in the group, and our amazing collaborators @alexwebblab @lab_costa @Fabrizio_Doc @Jaegerlab biorxiv.org/content/10.110…

Very interesting review. Worth a read: nature.com/articles/s4157…

Now online @emboreports : More insights into the importance of body temperature cycles: How alternative splicing coupled to decay (#NMD) can generate rhythmic gene expression (#circadian)! Thanks to our collaborators from #sfb973 and #Omiqa embopress.org/doi/full/10.15…