Deepak Khuperkar

For this year’s BCN XMas party dress theme the lab went for Peaky blinders 😊 and then the band #synaptic_soul with current and previous lab members brought the house down.

What is the link between hibernation and dementia treatments? This is the question that @JulieQLin and @DeepakKhuperkar try to answer in their latest project — we chatted to them to find out more blog.opentargets.org/rbm3-research-…

#HNRNPH1 regulates expression of the #neuroprotective cold-shock protein #RBM3 through poison exon exclusion @JulieQLin @DeepakKhuperkar et al @MallucciLab @RueppLab embopress.org/doi/full/10.15…

Happy to share the first paper from our @UKDRI Cross-Centre project with @MallucciLab in collaboration with @ule_lab and Metzakopian lab led by the amazing @JulieQLin and @DeepakKhuperkar. embopress.org/doi/full/10.15….

🚨 Hot off the press! A @UKDRI analysis of an Open Targets screen delves into the regulation of the RBM3 cold-shock protein, identifying HNRNPH1 as a potential neuroprotective target Congratulations to first authors @JulieQLin and @DeepakKhuperkar!

Ever wonder what happens to our brains at lower temperatures? Looks like our neurons enjoy a cool bath – thanks to increased expression of a cold-shock protein, RBM3. Check out our preprint sharing some secrets behind RBM3 cold induction. biorxiv.org/content/10.110…

Image 5 of 5: Lava lamps TAF15 (pictured in red) is a mutant protein involved in neurodegenerative disease. Here the TAF15 protein forms bubbles (green) filled with RNA, that assemble around the cell nucleus (blue). 7/7

@PMurawala @dfg_public @MDIBL @Dfg @IMPvienna @VBCF_Tweets Congratulations!

Happy to announce the acceptance of the first grant for my lab. The @dfg_public will fund a project on tendon regeneration in the axolotl. @MDIBL @DFG #Hannover_medical_school_MHH @IMPvienna @VBCF_Tweets

Our review on Heterogeneity in mRNA translation is out: sciencedirect.com/science/articl…

Check out our newest work investigating translation quality control using single-molecule imaging! biorxiv.org/content/10.110…

@PMurawala @MDIBL Congratulations Prayag!

I am happy to announce my next career transition. I will be moving to @MDIBL as an assistant professor from June 2020.

#FreeAccessProtocol this week for quantifying #translation of single mRNAs in live cells with the SunTag, MoonTag, and MashTag translation reporters go.nature.com/3cav1eP @MarvinTanenbaum @DeepakKhuperkar @T_A_Hoek #mRNAtranslation

Excited to share our Nature Protocols paper on Translation imaging using the SunTag and MoonTag systems! @MarvinTanenbaum @T_A_Hoek rdcu.be/b1U6a

(1/16) Let’s get ready to rumble! “IRES the Virus” in blue versus “Cappy” in green: a fight to the death on single mRNA (red) in a live-cell cage match. Details from @amandakoch92 here: biorxiv.org/content/10.110…

Our recent work suggests a new role for VCP and a stress-activated ribosome associated quality control (RQC) complex in mRNA release from translation for recruitment to stress granules. biorxiv.org/content/10.110… @umichrna @tim_stasevich @CUBIOCHEM1 @BioFrontiers @UM_Genetics

@Pabi_Sahoo @SSRN @CellPressNews Congratulations Bhai! Nice work

Disassembly of Axonal G3BP1 Aggregates by a Casein Kinase 2α mRNA Translational Switch @SSRN @cellpressnews Sneak Peek ssrn.com/abstract=34933…

The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation: cell.com/molecular-cell…

Check out my latest work where we explored the effect of NMD on disease genetics, CRISPR and response to cancer immunotherapy! A fruitful collaboration between the @GenomeDataLab, @BenLehner lab and the @LabVermeulen.

Our new preprint is online on the role of mRNA structural dynamics in controlling Argonaute-target interactions! biorxiv.org/content/10.110…

How are RNP granules transported to their final destination in neuronal cells? A new study by Ya-Cheng Liao et al., shows they're tethered to lysosomes via the protein Annexin A11... & ALS-associated Annexin 11 mutations disrupt RNP granule trafficking! cell.com/cell/fulltext/…