Seongyeol Park

Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr

I am pleased to share our work on Cavendish bananas, a clonally propagated crop. Using somatic mutations from >100 bananas collected worldwide, we reconstructed their global dissemination history and genetic microevolution under large-scale cultivation. researchsquare.com/article/rs-919…

@jakelee0711 Huge congratulations! Fantastic data and interpretations showing the detailed evolution of somatic copy numbers!

1/n Have you ever wondered whether an amplified oncogene in a patient’s tumor (HER2/EGFR/CCND1/…) is carried on extrachromosomal DNA (ecDNA) vs embedded within a chromosome? Bulk WGS + genome graph can hint, but in practice it’s often hard to resolve. Here is our new preprint.

So excited to see our work profiling the tumor microenvironment in triple negative breast cancer out @NatureCancer! Please give it a read, super proud of this one :) For a full description of what we found, see below for a detailed tweetorial. nature.com/articles/s4301…

I am honored to be part of this fellowship and look forward to engaging with experts.

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.110…

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) biorxiv.org/content/10.110…

The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! nature.com/articles/s4158…

🧬Excited to share highlights from our latest publication demonstrating preservation of clinical utility with whole genome sequencing (WGS) data generated from routine FFPE cancer biopsies! 🧵#CancerGenomics @SerenaNikZainal @EarlyCancerCam @MedGen_UOC nature.com/articles/s4146…

Peter Campbell leaves the Sanger Institute at the end of the year to become Quotient's CSO. A mentor and one of my favourite scientists. His foundational, profound and creative contributions to cancer genomics and somatic evolution have truly shaped those fields. [1/7]

It was fantastic scientific event. I gained valuable insights into cancer research and connected with peers for discussions. Many thanks to @NCICancerBio and the organizing committee. #NCI_JI_2024

I am delighted that my company (@inocras) shows the utility of whole-genome sequencing in real-world oncology! A prospective study with Ajou Univ. Hospital. nature.com/articles/s1227…

We are pleased that our analyses on somatic mitochondrial DNA mutations (mosaicism) in normal human cells are published! Great work @JisongAn. nature.com/articles/s4158…

Does cancer #evolution & intra-tumour heterogeneity predict long-term relapse? We tested the evolutionary paradigm in prostate cancer clinical trials with long follow-up, combining genomics with digital histopathology: nature.com/articles/s4301…

@jakelee0711 @BWFUND Congratulations on the amazing news!

7 years ago, I made the bold decision to move to the US instead of becoming clinical faculty in my home country. Through an adventurous journey, I'm getting closer to my goal. Thrilled and honored to receive @BWFUND #CAMS, which will lay the foundation for my research program!

Open #PhD position in my lab @humantechnopole in Milan together with @polimi. #DataScience for cancer evolution. Use #MachineLearning methods to analyse and interpret cancer single cell data and understand how to design better treatments. Join us!

I'm super excited to share Nimbus, our algorithm for automatic classification of cellular marker expression in multiplexed image data! Nimbus is a pretrained deep learning model that works out of the box across panels with any combination of markers (1/x) biorxiv.org/content/10.110…

@jakelee0711 @game_of_chroms @peter_j_park @elledge_stephen @SpecifiCancer @CancerGrand @TheMarkFdn Great work! Congratulation.

We should work together more on the breast cancer genomes @game_of_chroms! Thanks to our great mentors @peter_j_park and @elledge_stephen who inspired us throughout the project. Grateful to be part of @SpecifiCancer team supported by @CancerGrand @TheMarkFdn.

Often the most exciting moment as a computational biologist is when collaborating with an experimental biologist to explore functional aspects of the genome. I was lucky to partner with @game_of_chroms, who is full of grit and curiosity that have led to this exciting story!

We have just updated our database of (496!) funding opportunities for early-career researchers/faculty. For each entry, we provide link, $ amount, deadline, eligibility criteria. Download this database for free here: research.jhu.edu/rdt/funding-op…