Roman Huszár

So happy to share a big thing I've been up to in my PhD ! nature.com/articles/s4159… TL;DR: Neurons born together wire and fire together A long-ish thread. 1/n

New video is live! How does the brain select which experiences to remember, and which to forget? Turns out, specific patterns of hippocampal activity, called sharp-wave ripples, play an important role of "memory tags" 🧠 youtu.be/ceFFEmkxTLg?si… The video is based on an amazing work by @winnieyangwn @ChenSun92 @r_huszar @thainmueller Kirill Kiselev and @brainrhythms

Huge congrats to @Karyna_mi for her paper published today in @ScienceMagazine! She found that the hippocampus is really important for a key strategy we use to make decisions called hidden state inference! 🧪 🧠science.org/doi/10.1126/sc… 1/7

We are excited to share our latest work, in collaboration with Cheng Wang’s lab @flycattomoon, exploring the development of place cells during early life. @Chenyue22Wang nature.com/articles/s4146… @NatureComms

“How does local circuit architecture shape spatial representations in the hippocampal CA3?” ✨Excited to share my first postdoc work in @attila_losonczy lab @ZuckermanBrain now online as a preprint.✨ Check the link below👇 biorxiv.org/content/10.110…

“Where was I again?” Our study published today nature.com/articles/s4158… reveals brain cells can form a coordinate system for our behaviours. Instead of locating where we are in the world, this coordinate system tells us “where we are” in a sequence of behaviours: 🧵below:

Final paper from my Ph.D. is officially out: nature.com/articles/s4159…

✨We are hiring! ✨ We have a postdoc position open at the Charles University in Prague! If you are interested in memory consolidation and like to search for structure in neural data, get in touch! To read more about us, visit neam.mff.cuni.cz. Please RT 😊

📢 Our newest preprint is up—just in time for SfN! Come by the nano Tues am N228 for the 10 min version, or see 🧵 The unexpected punchline: when a chickadee looks at a place from a distance, the SAME place codes activate as if it were actually there 👁️ t.ly/wr5_J

Why are some neurons more selective than others? We report now in @Nature how calcium permeable-AMPA receptors in PV neurons make them less selective to sensory features nature.com/articles/s4158… Long live the geniuses behind this🧠🔍juhyun.kim @thainmueller @rhuganir

Hippocampus generates an internal model of Euclidean space. We ventured in a spatial odyssey exploring how much of the internal model is a priori, innate (Nature) and what is contributed by postnatal experience of Euclidean geometry (Nurture) Our answer@ nature.com/articles/s4146…👇

🏆Po mimořádném loňském úspěchu opět vyhlašujeme společně s @DianaBiotech druhý ročník Ceny Czexpats in Science pro začínající české vědkyně a vědce působící v zahraničí! 👩‍🔬🧑‍💻 Pokud jste někdo, kdo: ◽️má do 7 let od dokončení PhD, ◽️pracuje ve vědecké oblasti, ať už v akademii nebo mimo ni, ◽️má primární afiliaci v zahraničí a zároveň české státní občanství, neváhejte se přihlásit a zviditelnit tak svůj výzkum! Uzávěrka přihlášek je 30. listopadu 2024. 💸 Cena @czexpats je spojena s mediálním zviditelněním finalistů a laureátů a s finanční odměnou v celkové výši 75 000 Kč. Udělit se mohou až tři ceny! 🙏Moc se těšíme na všechny přihlášky! Rozhovor s loňskou laureátkou @marketa_tomkova si můžete připomenout tady 👉 czexpats.org/clanek/cena-cz… ℹ️ Pro přihlášení do 2. ročníku 👉 czexpats.org/cena/

My former PhD student @Peiyuan9 was profiled in @_TheTransmitter for her documentary "The opposite of dying" (internationally recognized at @sheffdocfest), which she made while doing a PhD on the cognitive mechanisms of procrastination. thetransmitter.org/craft-and-care…

New work with @Jack_W_Lindsey, Larry Abbott, Dmitriy Aronov, and @selmaanchettih! We propose a model of episodic memory where memories are bound to “barcode” activity patterns, enabling precise and flexible memory. biorxiv.org/content/10.110…

A Hebbian spike-time-dependent plasticity rule at inhibitory synapses supports replay generalization in the mouse hippocampus @neurozhen @LosonczyLab nature.com/articles/s4159…

🌟 We are recruiting two postdocs to our team 🌟 Focuses: 1. Systems Neuroscience, memory and cognition, and high-throughput electrophysiology in rodents. 2. advancing neuroscience through innovative open-science tool development (Brainstem). petersenlab.org/open-positions/ 1/4

🌱 Staňte se mentory mladých vědkyň a vědců z @UniKarlova a pomozte rozvíjet české vědecké prostředí! 🇨🇿👩‍🔬👨‍🔬 🔍 Mentorkou či mentorem se můžete stát, pokud: ✅ máte > 8 let od získání Ph.D., ✅ jste z akademické nebo neakademické instituce, ✅ působíte v Česku nebo v zahraničí, ✅ máte čas na alespoň 5 setkání (online/offline) s menteem v období 02/25–01/26. 📅 Přihlášky je možné podávat do 20. října! 📋 Více informací a přihlašovací formulář najdete zde: cuni.cz/UK-13908.html

論文をNature誌に発表しました! Prefrontal and lateral entorhinal neurons co-dependently learn item–outcome rules Heechul Jun†, Jason Y. Lee†, Nicholas R. Bleza, Ayana Ichii, Jordan D. Donohue & Kei M. Igarashi Nature (2024) nature.com/articles/s4158… 私たちが新しいことを学習する際、覚えた事柄は脳の中の「脳内分類表」に分類されて貯蔵されます。 新しく来たメールを、「会社」、「大学友人」、「サークル」、「趣味」などのフォルダーに分類するのと同じようなものです。関連した情報を一つにまとめ、効率よく記憶するための仕組みです。 私たちが学習する際、多数の神経細胞の電気的活動による情報演算が行われ、脳で脳内分類表が生み出されます。 このような脳内分類表はこれまでに、海馬・嗅内皮質・前頭前野などの記憶に関わるいくつかの脳部位で見つかっていました。 では、いったいどの部位が、このような脳内分類表を実際に作り上げているのでしょうか？ 私たちは今回マウスを使った実験で、嗅内皮質のなかでも「外側嗅内皮質」と呼ばれる部位と、前頭前野の二つの領域が協調して脳内分類表を形成していることを明らかにしました。 まず、解剖学的な実験から、外側嗅内皮質と前頭前野の二つの部位は、軸索を相互に延ばして双方向性の回路（ループ状の回路）を形成していることを見出しました。 次に、外側嗅内皮質の活動を人工的に遮断すると、前頭前野の脳内分類表が失われてしまい、マウスは学習ができなくなってしまいました。 さらに反対に、前頭前野の活動を遮断すると、外側嗅内皮質の脳内分類表が失われ、マウスは学習ができなくなってしまいました。 よって、外側嗅内皮質と前頭前野が、お互い助け合って、脳内分類表を形成していると結論づけました。 脳内分類表は、私たちの記憶だけでなく、判断や意思決定などの高度な認知機能に必須であり、脳が脳内分類表をうまく作れなくなると、様々な精神疾患を引き起こすと考えられています。 ついに「脳内分類表」が作られる脳部位が見つかりましたので、今後この結果を精神疾患の原因解明に応用したいと考えています。

📢📢 preprint alert! 🥳🤓 Hippocampal representation hierarchies are cool! And reshape in a smart way during learning! Great job Heloisa Chiossi!! w/ @michnard_, Gašper Tkačik and Jozsef Csicsvari. biorxiv.org/content/10.110…

New preprint post! We show that motor commands in the superior colliculus shift the internal representation of heading during REM sleep despite the immobility of sleeping mice. Thus, the brain simulates actions and their consequences during REM sleep.🧵1/7 doi.org/10.1101/2024.0…

How can memories persist in the brain when their properties and supporting biological substrates change over time and experiences? Our latest work newly published in @ScienceMagazine proposes that a balance between memory dynamics and persistence is achieved through the divergent recruitment of multiple memory traces established in parallel upon memory encoding. science.org/doi/10.1126/sc… Welcome to the Multiverse of Memory! A thread. 1/7