Ram Aiyar

𝐑𝐚𝐲𝐦𝐨𝐧𝐝 𝐉𝐚𝐦𝐞𝐬 𝐁𝐢𝐨𝐭𝐞𝐜𝐡 𝐈𝐧𝐧𝐨𝐯𝐚𝐭𝐢𝐨𝐧 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦: @KorroBio CEO @ramaiyar discusses how the company has chosen new RNA editing programs to move forward with this year. $KRRO Full video: biotechtv.com/post/korro-bio…

👇 ir.korrobio.com/news-releases/…

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State of mind 👇 open.spotify.com/track/5fpizYGb…

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Synthetic rescue! KRRO-121 in Hyoerammonemia. $KRRO

@RNAiAnalyst :) maybe in time once delivery to multiple regions in the brain has been derisked! Yes I am referring to tau knockdown.

@ramaiyar You got me excited for a moment, but you are probably referring to (intracellular) tau knockdown in the clinic by $ioms $biib, not ApoE RNAediting preclinical POC?

Pathological biomarkers (amyloid beta, tau) or genetic risk factor (ApoE)- which one do you consider the best drug target for #Alzheimer's?

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Crazy climb by @AlexHonnold Congratulations! #Skyscrapperlive

In a Godzilla state of mind -> fast and furious like Eminem! open.spotify.com/track/7FIWs0pq…

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👇 $KRRO #RNAediting

@GooseData It depends on what you doing or try to achieve. If you know the study conditions and are trying to iterate on something (compounds, sequence, etc ) then yes, when you are innovating on unknown biology, a bit harder.

This is goose advice for any biotech or pharma company. If you are running your own lab, you're living in the past!

@dvasishtha The question always comes from an ROI perspective for this endeavor. There is no doubt if you build it there is tremendous value early in life cycle, with a lot of investment, without a product in sight (maybe a service?) if cost/data point can be scaled then there is potential.

There really needs to be a venture firm dedicated to life sciences technology / tech bio. It's a middle ground that isn't perfectly serviced by biotech funds who make some platform investments or digital health funds that are spanning payer / provider as well as pharma / cro

@bryan_johnson Agree with the concept of constantly adjusting and taking a systems approach. Like most systems, there will be peaks and valleys as reactions, and predicting them would be hard! None the less, the mindset is important!

The coming years are going to be insane. I say this figuratively and literally. The primary reason is because society is about to enter a phase transition.  This is what a phase transition looks like. Water at 99°C is hot, stable, behaves like a liquid and follows the laws of hydrodynamics. At 101°C, water becomes a gas, making it chaotic, expansive, and following a different set of physical laws. The difference between 2026 and 203X is the difference between 99°C and 101°C. To make this tangible. Imagine you’ve become a proficient swimmer. Mastering your stroke, breathing and pacing. The water is a predictable substrate that you use to model your decisions. This is life at 99°C. At 101°C the pool turns to steam. You stroke your arms but don’t move. You kick and don’t find resistance. Your swimming proficiency is no longer an asset, it’s a liability. Your muscle memory is a mismatch for the new environment. You have to unlearn to relearn. This is what life planning is going to feel like going forward. For most of history, you could make a pretty decent guess about what the future would look like. If you were a farmer in 1400, you knew your grandchild would probably be a farmer in 1450. That was even true in 2003 when I entered college. One could confidently attend college, select a career, plan a profession, and map out retirement by age 65. We felt confident in these plans because we depended on broad trends (coarse graining) that reliably predicted the future. Things may change here and there, but not enough to give you any pause in your life-planning decision making. That stability is now gone. For example, my son is 20 and neither he nor I have any idea how to think about his life. Should he go to college? Is college still relevant? What should he learn? Life planning shortcuts are now dead. No one knows. Before, having a five year plan was responsible. Now it’s reckless because the world is moving faster than we can model. The speed of reality exceeds the speed of the observer. This is the source of the low level anxiety that many people feel. Humans are prediction machines. When an error emerges from what you predicted (water) to what you get (steam), the body registers it as trauma.  It leaves us in a state of chronic hyper-vigilance, scanning a horizon that refuses to sit still. In this new reality, the move is not to have better maps, but to build better systems. This is what I’ve been building with Blueprint. An algorithmic system of health and decision making that moves as fast as technology, allowing me to evolve alongside.  The more I detach from ideas, norms and expectations, the smoother the glide. The hardest part is letting go of what we know and trust. This is part of a series of essays that I’ve been writing for my upcoming book Warriors & Caretakers of Existence. A plan on what the human race does when giving birth to super intelligence. If we want the extraordinary existence that is on offer, we’ll need to fight for it.

We were grateful for the opportunity to share Korro’s progress at #JPM2026 this week. Our CEO, @RamAiyar’s, presentation reflected the strength of our science, our disciplined decision-making, and the momentum across our pipeline. A few highlights we were excited to share: - KRRO-121, a GalNAc-conjugated ASO targeting hyperammonemia, has anticipated regulatory filing in H2’26, and an analyst teach-in planned for Jan 27. - GalNAc-conjugated ASO intended for AATD achieved >90% in vivo RNA editing — the highest reported to date; DC expected in H1’26. - GalNAc-conjugated ASO targeting AMPKγ1 for longevity showed improved liver health in early preclinical studies in mice. - ASO modulating TDP-43 intended for ALS reduced aggregation and mis-localization and restored normal splicing in preclinical studies. - KRRO-110, an LNP-encapsulated ASO for AATD, terminated Ph 1/2 clinical trial following a clear, data-driven decision. Watch a recording of the presentation here: ir.korrobio.com/events/event-d… $KRRO

4) TDP43 modultsto for ALS Super Jazzed about the posibikites, differentiated for DNA editing Amazing crowd at #JPM26 in the room. $krro #RNAEditing

What did you miss $KRRO 1) KRRO-121 (GalNAc protein stabilizer) Teach in on January 27, 2026 2) >90% editing with GalNAc AATD asset in a week 3) AMPKg1 activator stabilizing liver function in DIO model (Longevity through liver health) @drmarkhyman @hubermanlab