Dr. Reg So

Happy to share that our seminal work on waixenicin A derivatization is now covered by a provisional patent: “Waixenicin A Derivatives as Neuroprotective Agents against Hypoxic Ischemic Brain Injury Through TRPM7 Blockade.” @RomoGrp_Baylor

Researchers in Science report a kilogram-scale synthesis of enlicitide, a peptide drug for lowering low-density cholesterol that is in a Phase 3 clinical trial. This new synthesis route leverages engineered enzymes and crystallization of key intermediates, substantially cutting down the number of reaction steps while improving yield. Learn more in a new #SciencePerspective: scim.ag/4wmd0n5

Cobalt-Catalyzed Highly Regioselective Alkoxycarbonylation of Olefins Driven by Light | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Our latest review titled "BASHY dyes as modular chromophores for multifaceted biorelevant applications: From imaging to photodynamic therapy" - now published in Chemical Communications pubs.rsc.org/en/content/art… @FcoGermanBldn @CIQSO_UHU @GoisLab @ChemCommun

A mild strategy compatible with various solvents, air, and moisture @angew_chem Congratulations to all involved! Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds doi.org/10.1002/anie.6…

Methylene CH can now be coupled with Aryl CH. The scope is limited, but what new ligand can do is always a pleasant surprise: pubs.acs.org/articlesonrequ…

X-Chem and CCG report DEL2PH4: a workflow that turns DEL data into predictive 3D pharmacophores, bridging DEL and medicinal chemistry to unlock actionable SAR for drug discovery. #ACSMedChemLett go.acs.org/e8y

Check out our latest work on @J_A_C_S : a ligand-controlled enantioconvergent homologation enables efficient access to chiral tertiary alkyl boronates. Congratulations to @MiaoChen1997, @AnkiZXXu and Coco! pubs.acs.org/doi/10.1021/ja…

In @NatureCatalysis we report the integration of photoredox radical generation and metal-carbenoid chemistry to achieve a formal metal carbenoid-radical coupling with enzymatic stereocontrol: nature.com/articles/s4192…

Zinc Redox Catalysis in the Photochemical Borylation of Fluorocarbons. New @ChemRxiv preprint from @yangwenbang0310 and the team. chemrxiv.org/doi/full/10.26…

In @Nature, we show that redox-active esters can be transformed into alkyl zinc species useful for transmetalation, providing a solution to rate matching in XEC reactions! First application: alkylation of alkenes via polar decarboxylative cross-coupling! nature.com/articles/s4158…

We summarize recent advances in α-ammonio radicals on @ChemRxiv . chemrxiv.org/doi/full/10.26…

A new direction in our pyridine phosphonium ion program: Phosphonium Ions as Activating Groups for the Selective Alkylation of Pyridines and Polyazines. chemrxiv.org/doi/full/10.26…

Check out team MOFganic's newest entry, out now in @J_A_C_S! Superstar PhD student Yihuan showed that MOFs allow for dosage delivery of simple fluorinated gases, enabling switchable control over borylated vs iodinated product formation in electroreductive radical reactions.

For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA. But new research into how bacteria defend themselves from viruses now shows this synthesis rule isn’t absolute. Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide. Learn more: scim.ag/4tTc5IA @NewsfromScience

Our review article is now out in Chemical Communications: “Nitrogen Editing of Aromatic Rings: From Skeletal Editing to Fragment Editing.” Congratulations to Hikaru!!　Two days in a row!! doi.org/10.1039/D6CC01…

🎉 Chuffed to see our JACS paper is among the most read articles this month! See how a boron-mediated Ni/photoredox strategy for hydroalkylation of olefins enabled the access to quaternary carbons. pubs.acs.org/doi/10.1021/ja… Congrats Team! #Photoredox #Organoborons @BristolChem

Our latest review has been published in Organic Chemistry Frontiers @OrgChemFront : “α-Borylcarbene Precursors: Design, Generation, and Synthetic Opportunities” doi.org/10.1039/D6QO00… Big congratulations to Ryuya and Kei @DJmuto !!

We are pleased to share our Nat Rev Chem review! We summarize how photo-, electro-, and electrophotochemical strategies are reshaping C–N bond formation, distinguishing them from traditional metal catalysis toward more sustainable synthesis. @natrevchem dlvr.it/TS7DlQ

Good news! The ICOS 2026 Early Bird registration deadline is extended to April 30! Don’t miss out - register now and save with the Early Bird rate! Icos2026.com #ICOS2026 #EarlyBird #Chemistry