Ralph Patrick

📣PhD opportunity on gene regulation, computational biology and ageing! Australian / NZ "domestic" students! Join a multidisciplinary team at #UQ , Group of Eight university, in sunny Brisbane! study.uq.edu.au/study-options/…

🙏 to Manuel Serrano for writing a preview 👉 doi.org/10.1016/j.cmet… for our study NOW IN PRINT @Cell_Metabolism. We introduce the "Stimulus-Induced Programming Hijacks Ontogeny" (SIPHON) model for chromatin & transcriptome remodeling in organismal maturation & aging We provide compelling data that “cell identity loss” in aging represents the hijacking of a developmental mechanism via epigenetic de-repression of AP-1 rich regulatory elements through stress/stimulus processes. The resulting predictable transcription factor network changes may drive many aging phenotypes. Link to our study 👉 doi.org/10.1016/j.cmet… It was an absolute pleasure to work with @Cell_Metabolism & @AmberMuellerPhD The project spanned 15 labs and was led by talented co-first authors @rjPatrick19 & @MarinaNaval, with crucial contributions from @nikkideshpande, Yifei Huang @Jason836452, Jingyu Zhang @IAMorlandozhang, Xiaoli Chen, Ying Yang @haokandeyy, @Mohammad_E1990, Kanupriya Tiwari,  Minh Tran, @AMohamed85, Binxu Wang, Di Xia, Jun Ma, Jacqueline Bayliss, Kahlia Wong, Michael Hun, @Sallyxsun, Benjamin Cao, Denny Cottle, Tara Catterall, Hila Barzilai-Tutsch, @robinleetroskie, @ZhianAnthony, Andrea F. Wise, Ye Mon Soe, Snehlata Kumari @Sne_K, @TheSweetGroup, Helen Thomas, Ian Smyth, Anne Fletcher @ImmunologyMelb, Konstantin Knoblich, @MattWattUnimelb, Majid Alhomrani,  @WalaaAlsanie, @DrQuinn4realz, @Tobias_Merson, Ann Chidgey, @SharonRicardo1, @YUmmunology, @JardeThierry, @SethCheetham, Christophe Marcelle, Susan Nilsson, @Quan_Nguyen_UQ & @MelanieDWhite

Was a great event last year, looking forward to this year!

Our new @Cell_Metabolism study proposes a mechanistic connection between molecular remodelling in development & aging. We uncovered a common transcription factor pattern linked to chromatin remodelling in organismal maturation & aging. Link tinyurl.com/d39ru3s8 Thread 🧵👇1/10

New publication from our Lab ⁦@ScienceAdvances⁩ 🚨 Honoured to have played a substantial role in it! 😃 🧵1/5 Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologies science.org/doi/10.1126/sc…

🎉 The ASSCR ECR QLD Symposium had 100 bright minds gathered. A huge thanks to all attendees for their remarkable contributions.🔬Congratulations to our Best Talk Winners 🏆 Imaan Ahmed (Student) and Mertem Weger (Postdoc), to be featured on our National Stem Cell conversations.