Ryan McEntush

we live in interesting times. join me in monitoring the situation. news, tweets, flights, ships, tv, etc. — one feed, live. link (desktop only) 👇

@RuxandraTeslo @WorksInProgMag @stripe Congrats!

Thrilled to announce I'm joining @WorksInProgMag and @stripe to continue my research and writing on clinical trials & biotech innovation, with many more articles to come. (If you haven't already, subscribe to the magazine. It's great in terms of content and very beautiful.) My work is driven by a core conviction: in the years and decades ahead, we will be far more constrained by the quality of our culture and institutions than by technology itself. In biology, a remarkable convergence is underway. AI, alongside a wave of other emerging tools, is fundamentally expanding what science can do. But beneath this sizzling potential, something is going wrong in Western biotechnology. China is pulling ahead and companies are increasingly moving clinical trials there, drawn by faster clinical trial timelines and a more dynamic ecosystem. Promising therapies sit in limbo for years. Despite the science being here, personalized cancer therapies are not viable to anyone but a few who can afford to navigate the labyrinthine regulatory apparatus. And pharmaceutical R&D productivity has remained stubbornly flat in the last 10 years, after decades of decline. And I can't imagine a better home for my research and writing on what can be done to accelerate biomedical progress than Works in Progress. This is a magazine that has published some of the most important writing on why the physical world has stopped working, including "The Housing Theory of Everything," which became one of those rare pieces that actually changed how people think about a problem. But this is not just about my desire to study biotech innovation. Biotech is not an anomaly. The same pattern: technology outrunning the institutions meant to govern it, is playing out across society. And now AI is compressing the timeline, accelerating pressures that were already straining the system. When people ask what I worry about when it comes to AI, I tell them it’s not the usual things. I'm not losing sleep as much over AI taking my job. I am more worried that we will lose our appetite for depth and that long-form thought, serious reading, sustained attention, the very things that make culture worth having, will erode faster than we notice. That our collective intelligence will hollow out, gradually. And the very problems we have now will only accelerate. @WorksInProgMag is a resistance movement against that, condensed in the form of magazine. It stands for long-form, in-depth writing. It stands for beauty. It is fundamentally anti-slop. In that sense, it's a natural fit with @stripe. A payments company publishing a magazine might seem like an odd pairing. That is, until you understand what kind of payments company @stripe actually is. It has always been driven by a genuine passion for craft and for getting small things exactly right. I am really proud to be part of something that embodies my own values in such a deep way, especially at a turning point in history.

surprise birthday for @CatOrman1!! everybody’s here!

@sfboehner is there a good write up of what went wrong?

@rmcentush As an investor you would sue the ceo for misuse of funds if they did what they did with Tunnel tops.

The Presidio is truly incredible. What they pulled off with Tunnel Tops should be the template for the rest of the park. Insane that there old buildings rotting away! The entire Presidio Trust board was fired last month. I hope the new one fixes this.

@ashwinl tragic

@rmcentush Agree w desire for change in Presido. But sadly, Tunnel Tops took more than a decade. Look up Doyle Drive Task Force. Construction started in 2009. Opened on 2022. We need faster! Look

@lmcorrigan1 I’m running a deep research to get the lore as we speak

@rmcentush Was the board that got fired largely the same that was responsible for the Tunnel Tops? If so they deserve credit for Tunnel Tops... why has it been relatively stagnant since?

Today marks the beginning of a new era. Introducing: Cowboy Space Corporation. We are building orbital infrastructure for the AI era: a fully integrated system of rockets and satellites designed to deliver high-performance compute and optical data transmission directly from Low Earth Orbit.

.@ianbrooke is one of the most amazing, inspiring founders and engineers out there. He also has the coolest lab in San Francisco, full of robots, CNC machines, turbines, electronics, etc. It's like a candy shop for an engineer. So excited to see the progress they are making at @AstroMechanica

remarkable that it's all working, financial gains are democratized via public equities, and the consumer surplus is already insane. it's okay to be optimistic

It's been 2+ years since S3 last featured @AstroMechanica — they've been quietly building a new vision of supersonic passenger travel. By building electric adaptive engines (efficient at every stage of flight) to reimagining airline economics itself, @ianbrooke and team's next step... is taking flight.

the incredible @AshleyAPelzel is hiring an EA at @AstroMechanica — if you are a world-class operator who can own calendar, communications & logistics for our exec team, DM me 👇

Two engineers, same job, two LinkedIn job descriptions... Hire beaver on the left 10/10 times

@jesslionness Welcome!

we should give 01 visas to everyone who works in F1

time to monitor

@creatine_cycle wow this did better than i thought

we have shenzhen at home

Overhead in Silicon Valley: "are you destined to deal?"

walking around a casino with blowdart of retatrutide