
Robert Ługowski
472 posts

Robert Ługowski
@robertlugowski
Managing Business Angel network, Angel investments, venture capital, early stage investments in startups


We've spent 50 years trying to kill cancer cells. What if the answer was never to kill them but to remind them who they are? Cancer cells aren't foreign invaders. They're your own cells that lost their identity. They stopped differentiating, stopped maturing, and started growing without limits. Cancer doesn't create anything new. It hijacks normal biology. Researchers at KAIST in South Korea identified three master regulators, MYB, HDAC2, and FOXA2, keeping colon cancer cells locked in a malignant state. When they silenced all three? The cancer cells differentiated back into normal, healthy tissue. MYC and WNT pathways shut down. In mice, tumors shrank significantly. No chemo. No radiation. Just reprogramming. Here's what most people will miss: HDAC2 is a histone deacetylase. It compacts DNA and silences tumor suppressor genes. We already use HDAC inhibitors in our protocols. This isn't new to us. But it's powerful validation. Cancer and aging are the same problem. Cells that no longer serve the body but learned to hijack the immune system to survive. The answer isn't bigger bombs. It's restoration. Still preclinical. But the direction is exactly right. Kudos to the @kaistpr team. 👏




















I’m super excited to have you join as CEO of this new group, Sam, setting a new pace for innovation. We’ve learned a lot over the years about how to give founders and innovators space to build independent identities and cultures within Microsoft, including GitHub, Mojang Studios, and LinkedIn, and I’m looking forward to having you do the same.













