boss charles

@toonces4280 The 12 month data from the RCT did fail though? It was a reversal from the observational data? Who cares what the observational data shows if it can’t be replicated in a randomized fashion?

30,000 Americans are symptomatic with Huntington's disease right now. Another 200,000 carry the gene. There is no approved treatment that slows progression. None. AMT-130 showed 75% slowing at 36 months. The 48-month data drops this summer. If the numbers hold, the FDA will have to explain why it spent months calling this therapy "failed" instead of reviewing it. $QURE #HuntingtonsDisease #AMT130

@DarrenEstes Hey chief in the randomized control trial it didn’t do that at all.

Significantly less because it’s slowing the disease by 75%. Cancer patients spend a fortune for drugs that add a few years to their life. $qure. In any case, should anyone put a price on what a life is worth?

@Oceanbreeze473 Absolutely

Should you be allowed to SHOOT a person who has broken into your house .. even if they are UNARMED?

@viatoCEO @anish_koka The “confirmatory rct” is already being run and it doesn’t work so far my man

@anish_koka I can’t speak to all of the treatments listed above, but the clinical benefit of $QURE AMT-130 paired with the reduction in cerebrospinal fluid neurofilament light is enough evidence to support accelerated approval while a confirmatory RCT is run Experts are telling us it works.

Right but just doing something because there’s nothing else to do is pretty problematic as well. Speaking as a loved one of a rare disease patient.

@MartinShkreli @johnarnold The drug doesn’t work Martin

all because this douchebag @johnarnold doesn't think rare disease patients' lives are worth anything easy to say until it is your family member who has DMD, SMA, CF, HD, etc.

Oh come on… On self-referral “conflict of interest”: The Stark Law already governs physician self-referral. POH physicians must publicly disclose their ownership interest to every referred patient. Now… what do hospital controlled doctors disclose?? Nothing. They have zero disclosure obligation when they refer patients to the same corporate system that signs their paycheck. They are systematically incentivized to use higher-cost outpatient hospital settings rather than independent facilities. A 2020 Journal of General Internal Medicine analysis of Texas BCBS claims found hospital-owned physician practices generated 5.8% higher annual spending, 13% higher imaging costs, and 21.7% higher outpatient facility costs than independent practices, driven entirely by utilization and site-of-service billing. If the concern is financial conflicts driving utilization, the data points to hospital consolidation, not physician ownership. On the “data is clear” claim about cherry-picking: The data is actually clear in the opposite direction. The 2015 BMJ study examined 219 POHs and 1,967 non-POHs across 95 hospital referral regions and found Medicare patient proportions were statistically identical with 47.1% at POHs versus 47.2% at non-POHs. Medicaid proportions were 14.9% versus 15.4%. Minority patient proportions were similarly equivalent. The 2024 Physicians Advocacy Institute analysis of 20 high-cost DRGs found no evidence of cherry-picking after controlling for patient age, race, and health status. At the same time they found POHs delivered care at 8-15% lower Medicare cost per episode. The 2023 JAMA Network Open study found POHs had 17.5% lower commercial negotiated prices and 46.7% lower cash prices in the same geographic markets. The “cherry-picking” narrative collapses under peer-reviewed scrutiny. On rural hospital harm: The FAH report this argument relies on was commissioned by the Federation of American Hospitals and the American Hospital Association. It is a modeled simulation based on hypothetical scenarios, not observed real-world outcomes. The legislation in question (H.R. 2191) specifically requires a 35-mile separation between a new POH and any existing rural hospital, which is a provision designed precisely to avoid the competitive overlap this model assumes. More importantly, 152 rural hospitals have closed since 2010 (when the POH ban took effect). The ban did not protect rural access. It accelerated consolidation, reduced competition, and drove up costs. Markets with POHs have 16.7% lower concentration scores than markets without them. The real threat to rural hospitals is a Medicare reimbursement structure that already produces -11.8% Medicare margins for sole community hospitals. Fixing that requires payment reform, not protecting incumbent hospital systems from physician-led competition. What’s perhaps not discussed enough is that nearly every procedure performed in hospitals today is subject to utilization review (prior authorization). If someone is looking over the claim to make sure it is indicated and medically necessary, all of these arguments go away anyway. It doesn’t matter if the physician takes the procedures to their own facility, particularly if the physician hospital provides the same or better quality and the same or lower price. The ACA Section 6001 ban on physician ownership was legislative horse-trading, so let’s not pretend to take some high road that this is about protecting patients. Fifteen years later, consolidation has accelerated, patient choices have narrowed, and the organizations lobbying hardest to keep the ban are the ones profiting most from it.

@NexXVill @MattLeinartQB If you win the heisman and a natty someone else has to pick a different numba champ

@MattLeinartQB You truly believe you’re the only human who should wear 11 for the rest of USC program history. Retired numbers are so silly. Like god forbid another human likes 11

Coach Riley hasn’t asked me if a recruit can wear my number so we can settle that right now. I’ve been asked in the past before and have said the same thing every time. This isn’t a big deal! Fight On ✌️

Rolijah hardy

@gregthesorcerer What does the interior look like?

This is where I post from

@CommonSense3241 @peter_mantas Direct reversal from their observational data. I concur need to keep following those patients, but at year 1 the controls doing better than any arm is concerning, hence why we can’t do an early approval. For HD patients I hope it works, but not convinced yet

@rockstopher2 @peter_mantas Looking at 1 year mark of a disease that takes 15 years to die from?

Take your time to digest what this means. I’ll give you a second.

@betterpubpro What is the name of the game?

🩸 It’s not Diablo. ⚔️ It’s not Path of Exile. 🕯️ It’s not Tibia. But if our indie game reminds you of them… we’re probably doing something right. ⏳ Last day to play the demo on Steam! #pixelart #indiegame #gamedev #arpg #indiedev #pixelartgame #dungeoncrawler

@LabbRadar If it worked so well it would have worked it the RCT chief

$QURE It requires forcing desperate patients with a 100 percent fatal genetic disease to undergo invasive brain surgery solely to inject a placebo, while withholding a therapy that has demonstrated 36 months of profound disease slowing.

The recent apologia for former CBER Director Vinay Prasad by Dr. Anish Koka is a masterclass in narrative framing over scientific precision. $QURE 🧵

@Dr_R_Kurzrock It’s worse to approve the drug that doesn’t work and make everyone else pay for it

For fatal disease, Is it worse to approve agent with a possibility of it turning out to be ineffective because trial was imperfect, or is it worse to delay possibly effective agent waiting for perfect trial that requires forcing desperate pts to undergo sham brain placebo surgery

Medicare premiums for seniors were 10% higher last year because of overpayments to private Medicare Advantage plans. Our government paid $84 billion more than it would've cost to cover the same beneficiaries under its own government-run Medicare plans. We are effectively being robbed by private health insurers through over-billing and inflated coding, and nothing is being done about it.

@bitcloud Didn’t actually cure it big dog

4. Curing your dog's cancer

@GarrettPetersen Nope

So we could cure all cancer easily, if not for the procedural barriers?

@yishan Lol, complete bullshit. China, despite it’s massive educated population, has trouble doing basic science research because of incredible academic dishonesty that permeates their academic institutions

What we’re basically going to see happen is that China is going to cure cancer. If you want a map to all the technological advances you’re going to see in the next 10 years out of China, the formula is “technology now makes it possible to do X, but it’s really hard to do X in the United States.”

I can understand if this story is false but Patrick’s take seems confusing. Many people would pay $100,000s to cure a loved one of cancer. Either that’s possible or it’s not.

@liminal_warmth Big chief, the vaccine didn’t cure the dogs cancer

1. What Let the dying people try the $100k personalized vaccine. Jesus. This is the kind of thing that makes me want to go full Joker mode on health regulation