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Roshan Kumar
116 posts
Roshan Kumar
@roshan_kkumar
Research Investigator @umichmedicine,Biological chemistry,Redox metabolism,Mitochondrial signaling,H2S biology,CRC,IBD #Ruma Banerjee lab,Father
Ann Arbor, Michigan Katılım Şubat 2014
915 Takip Edilen235 Takipçiler
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I'm excited to share that I've received the K99/R00 Transition to Independence Grant from @NIHAging to study the role of host-microbe interactions in regulating stress response and longevity. A huge thanks to @Leiserlab and the @UMPhysiology for all their support along the way.
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Roshan Kumar retweetledi
Congratulations Hannah!
Hannah Bell@Hannah_N_Bell
So excited that our review article on the role of ferroptotic cell death in immunity is finally out! Check it out to learn how this iron dependent cell death pathway regulates immune responses in tumors, autoimmunity, infection and homeostasis. @bstockwell @ImmunityCP
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Roshan Kumar retweetledi
Latest from the Laboratory of Functional Proteomics @unescorcb. Heartiest Congratulations 🎉🥳🎉to @sushant16m8 and the team @SahaSandhini @Ranikisbt @Tushar_RCB.
@jbiolchem
doi.org/10.1016/j.jbc.…
Sushant Majumder@sushant16m8
@Tushar_RCB @SenSobhan @SahaSandhini @Ranikisbt @PhdError @jbiolchem Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation doi.org/10.1016/j.jbc.…
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Roshan Kumar retweetledi
Exploring more amyloidogenic proteins?? In our first study we showed Otub1, a deubiquitinating enzyme has a huge potential to form an amyloid and potentiates co-aggregation of alpha-synuclein. our recent publication described the mechanistic insights of Otub1 amyloid aggregation
Sushant Majumder@sushant16m8
@Tushar_RCB @SenSobhan @SahaSandhini @Ranikisbt @PhdError @jbiolchem Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation doi.org/10.1016/j.jbc.…
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Roshan Kumar retweetledi
@Tushar_RCB @SenSobhan @SahaSandhini @Ranikisbt @PhdError @jbiolchem
Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation
doi.org/10.1016/j.jbc.…
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Our work is online now @jbiolchem. We have developed a methodology to capture coenzyme Q redox state. Credit goes to Victor Vitvitsky.
Rapid HPLC method reveals dynamic shifts in coenzyme Q redox state - Journal of Biological Chemistry jbc.org/article/S0021-…
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Our latest research in @ScienceAdvances highlights the role of stress-driven microbial evolution in regulating host longevity and stress signaling. @Leiserlab @YatrikShahLab @UMPhysiology #aging #microbiome #Celegans #longevity #F5" target="_blank" rel="nofollow noopener">science.org/doi/10.1126/sc…
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Lay perspective of our work covered by @umichmedicine michiganmedicine.org/health-lab/dis…
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Synergizing with hypoxia, SQOR deficiency induces a reductive shift in the ETC and
restricts proliferation.
SQOR KO mice exhibit lower neovascularization in tumor xenograft and hind limb
ischemia models.
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Hypoxic induction of •NO in endothelial cells inhibits CBS and switches CTH reaction
specificity.
Hypoxic interruption of the canonical transsulfuration pathway promotes H2S synthesis.
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I'm thrilled to share, our work is online now @nchembio. Huge thanks to Ruma Banerjee, @YatrikShahLab @lyssiotis and all authors @rashi_singhal7 @SumeetASolanki @SAlibeckoff @Hannah_N_Bell and others.rdcu.be/dBSCb
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Congrats @dhanna194 @diesejutter for this wonderful study explaining the effect of sulfide and oxygen intersection on metabolism. H2S preconditioning induces long-lived perturbations in O2 metabolism | PNAS pnas.org/doi/10.1073/pn…
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Happy to share our new work where we took a deep dive into ER-mito contact sites and metabolic cell bio! Thanks to all the authors and most importantly @YatrikShahLab and @LyssiotisLab for their support. I will share some snippets of this journey from my perspective (🧵👇) (1/n)
bioRxiv Cell Biology@biorxiv_cellbio
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III biorxiv.org/cgi/content/sh… #biorxiv_cellbio
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Roshan Kumar retweetledi
Our study where we show role of neutrophil specific HIF2a in colitis-associated cancer is selected for APSselect award in @ajpgi. Proud moment for @YatrikShahLab. Thanks to @APSPhysiology
APS Publications@APSPublications
👏Congratulations to @rashi_singhal7 @nikhil_kotla12 @YatrikShahLab on January's #APSselect award in @ajpgi! Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer (Rashi Singhal et al.) ow.ly/VX0e50QnooX @UMPhysiology
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Roshan Kumar retweetledi
Thrilled to present and chair a session of Nanosymposium #SfN2023.
Come check out my talk about the functions of NPY in the sympathetic neurons.
Exciting collab. between the @rkuruvi1, twitterless Raluca Pascalau @SamerHattar, and @ETampakak teams.
@JohnsHopkins
@SfNtweets
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