DooDooDoo

@MadonnaUltimate @xoxoGossip_Boy Managing to be no 1 isn’t culture it’s great business

@xoxoGossip_Boy Not sure about innovation but for sure taylor has managed to be no1 in the industry which is an amazing feat , i acknowledge this and im not even a taylor stan.

RYAN MURPHY: This is 100 percent true. Madonna is THE most important artist of the last 50 years. No one comes close in cultural import, other than Taylor Swift and Paul McCartney, both of whom are truly incredible artists for the ages. The road that Madonna traveled is truly original and lonely and a first. I love hearing a defense. I LOVE Wesley for this viewpoint. It's truly emotional, it makes me emotional.... someone who had such an influence on my life who was ALWAYS misunderstood.! The hate Madonna has received, and survived. It's beyond comprehension. There is no one in my lifetime who has meant more to me, or had more of an impact on art, fashion, music, ALL OF IT. Than Madonna. Via MadonnaLiteral

@anoethertheorem @bryan_johnson It obviously hasn’t really taken off otherwise that thought would never happen

@bryan_johnson Blueprint should never die, the stack has impacted my life in so many positive ways that I can’t live without it.

Last year I nearly shut down Blueprint. My reasoning was that in the grand game of existence, getting our societal goals right is the only thing that matters. In the long arc of time, it wouldn't matter if I built a longevity company. I wanted to invest all of my energy into Don't Die. Maybe I'm naive, however it seems obvious to me that when your species is giving birth to superintelligence, your sole concern becomes survival. Not because you're scared or fear what may come, but because you realize that superintelligence is big. Bigger than any of us can imagine and happening faster than our intuitions allow us to model. This is a hard concept for Homo sapiens to understand because we are not good at understanding our limitations of knowing. In the void of not knowing, the one thing that we each know to be true is that none of us want to die right now. When tomorrow arrives, that will be true about the next day too. Don't Die is not about immortality. It's about the most basic observation of intelligent life, we want one more breath. Just as Homo erectus, a million years ago, with an axe in their hand, was unable to articulate our modern world, we are once again Homo erectus relative to AI. We may experience a million years of relative progress in the next 10, 20 or 50 years. Given this, Kate and I have cycled through this problem hundreds of times over the past few years. How can we get the world aligned around Don't Die? Committed to the idea that in spite of our many differences, we share a planet and a common interest in tomorrow. Basically, how can we make existence profitable and die unprofitable. We saw the problem as two-fold. One practical and one spiritual. Practically, we need things to work in the world: clean water, transportation, energy, security, stable institutions, communications and health care. Spiritually, we need purpose, existential explanations, and hope. We also need progress and adventure: solve aging, abundant AI, creative joy and expression and things to build. We decided to build on both fronts. Blueprint would be the practical, a company aligned to Don't Die. A group of humans that labor together to help other humans thrive as their sole objective. To hold ourselves to a standard of making existence profitable and die unprofitable, for ourselves. To never let profit corrupt this goal. Sounds simple until you take stock of how many companies make their living on making humans die. Sometimes this is done openly and other times it's hidden in a mesh of poorly aligned incentives that are invisible. This is not an esoteric philosophical argument, death is measurable in a biological system. You can get clever and find arguments ("does this mean we shouldn't have children?") but we know death and life when we see it. On the spiritual side, we think that 2027-28 is the breakout time for Don't Die. Maybe we're off by a year or two, but we think it's soon. We believe that AI will create several societal shocks, none of which we will predict accurately, but will leave the world feeling unmoored. Hopefully it won't be catastrophic, but will be a cold water dunk we need to awaken us to the realization that no one really wants to die right now and that our current societal systems that profits from death are ill suited for this moment. That in our most sober moments, when at funerals, or after a near-death experience, we see clearly, even if for a few minutes. Above all, we care about life more than anything else. All else fades away in those moments. We see with crystal clarity that all the other stuff that had us entranced wasn't that important after all. I write this for two reasons. First, to invite you to build Don't Die in the practical world. Capitalism (profit and loss) is a good system that has done society well. In whatever you're building, align your and your organization's efforts with a loyalty to acting in people's best long term interests. Don't do things that cause other people to die, commit self harm, or create societal harm. This doesn't mean being paternalistic, it means using your best judgement about how you'd want someone else to treat you if the roles were reversed. Second, to ready yourself for the new philosophy that will be arriving shortly. One that prioritizes our shared existence and vitality above all other goals. Don’t Die is the foundation. Immortalism is what we’re going to build. Again, not for selfish reasons, but because we understand that we are warriors and caretakers of intelligent life in this part of the galaxy and we take on this responsibility with honor and nobility.

@Apfelbaum86 @elonmusk @davidasinclair Literally a comment I’ve left here a few times ! 😂😂 I’m like can we at least look amazing while we wait even if not reset on the inside!! 🤣🤣

@elonmusk @davidasinclair Please find something to stop or reverse at least the aging skin 🙏. That's what makes people look old and tired, even if they feel young and energetic.

You’re right @elonmusk. Focus on this topic. Aging has a relatively simple explanation and is apparently reversible. Clinical trials begin shortly🤞

@dave_imagines @elonmusk @davidasinclair Young adult my dude

@elonmusk @davidasinclair How far back can we go?

@sgtesco @elonmusk @davidasinclair You don’t “do your 20’s again” it’s not a Time Machine. You’ll be 70 in a 20 year old body with you 70 year old wisdom

@elonmusk @davidasinclair Please I can't do my 20s again!

@SciTechera Waste of time. I see exactly zero difference in those. If it can’t easily be seen at a glance let alone hurting your eyeballs trying to compare the images then no one cares and it doesn’t work lol

Skin Aging Breakthrough Scientists just reverse biological age at the DNA level. A 2026 clinical study published in Dermatology and Therapy shows that skin aging isn’t just about wrinkles or sun damage. It’s driven by epigenetic changes, specifically DNA methylation patterns that control how genes behave over time. Researchers analyzed skin samples across multiple ethnicities using advanced methylation profiling and confirmed that epigenetic aging follows a shared biological pattern, regardless of skin tone. In other words, aging looks different on the surface, but underneath, it runs on the same code. The team then tested a topical compound called dihydromyricetin (DHM) on 60 participants over 8 weeks. The results showed a statistically significant reduction in biological skin age, along with visible improvements in wrinkles, skin texture, and structural density. DHM works by inhibiting DNA methyltransferase 1 (DNMT1), helping reverse age-related gene silencing and restore a more youthful gene expression pattern. This isn’t just cosmetic skincare. It’s early evidence that aging can be partially reprogrammed at the molecular level, pushing skincare closer to biotechnology than beauty. We’re not just slowing aging anymore. We’re starting to edit it bro 👀

@AgingBiology @davidasinclair 🙄🙄 he hopefully won’t get to have it

Putin declares war on aging with $26 billion vaccine project nypost.com/2026/05/02/wor…

@davidasinclair Omg please let this be available soon! My mother needs this badly

😎👏 Throw in OSK

@micsolana @bryan_johnson She sounds pretty personal to me. Shes fuming and she hates him. And of course she does because the movement is taking all her copes away

@bryan_johnson I don't think it's personal tbh. what I have realized with kara is she really is a misandrist, and is actually incapable of talking about almost any man without insulting him. honestly, I don't even know if she realizes what she's saying half the time. it's a reflex.

Kara Swisher says I have a male eating disorder. She's closer to right than she knows. There is a decade of my life where I didn't take any pictures of myself because I was overweight, unhealthy, and sad. That version of me ate his feelings and self-destructed. No one called that version sick. The obsessive measurement didn't create the disorder. It was the treatment for one that already existed. My internal signals were so broken I couldn't trust them. I needed external data to find my way back. I had to rebuild from scratch. Kara says this is body dysmorphia cosplaying as science. I'd say it's what happens when a person loses the plot so completely that the only way home is through the numbers. I publish it all. Including the failures, embarrassment, and the erection data, because hiding is what created the disorder. She can call it a circus, repellent, or eating disorder. You cannot call it hiding.

@taz_devi @davidasinclair That was my first thought 3 years ago when I came across this.

@davidasinclair or is this a part of living longer? We no longer need to produce as many if we all live much longer?

It's a worry

@sama That’s absolutely abhorrent. People need to get a life. Unbelievable 😤😤😤😤😤

I wrote this early this morning and I wasn't sure if I would actually publish it, but here it is: blog.samaltman.com/2279512

@davidasinclair Higher vitamin d ages you? 😯

And cooked potatoes 🥔

@ViralClipmax @Cobratate @bryan_johnson 🤣🤣🤣🤣🤣🤣

@Cobratate @bryan_johnson

Just had sex with Kate. Goodnight everyone.

@paige_eden It’s all fillers hun

Babe it’s called an ethnic nose job trust me I’ve had three! Also she clearly had jaw surgery.

@davidasinclair Thanks but no thanks. We should never get to the point of needing it in the first place

Or some kind of LDL lowering medicine. There are newer ones than statins

@davidasinclair And it doesn’t have to classified as a disease. It’s not a nice thing. If we find out that it can softened, reversed etc why wouldn’t we do it? Also our ability as a species to find workarounds on things that aren’t that way “naturally” is our main NATURAL CHARACTERISTIC

Apparently aging isn’t a disease because it’s “natural,” therefore it should be managed, not treated I disagree. Aging has causes, biomarkers, clear pathology, and is modifiable If something can be measured & treated, it should be considered a disease tinyurl.com/3vee3f62

@davidasinclair I’ve been saying this for over a decade now! Specifically started with my arguments around weed. Where people would tell me it’s better than cigarettes because it’s “natural” and what is tobacco??? Or alcohol. Everything is natural including chemicals

Natural doesn’t mean good. Heart disease, Alzheimer’s, cancer - all natural

@RyanSChandler1 @james_xond Saaaammeeeee 😂😂😂

@james_xond I already don't drink alcohol so easy money.

You’re offered $1M, but you can never drink alcohol again. Could you do it?

@davidasinclair @StevenBartlett Finally!! I was wondering when you were going to go on this one! lol. Ant wait to watch.

Great convo with @StevenBartlett at DOAC with a bunch of props He wasn’t too happy I insisted he stay longer in a suit that mimics aging. Reason: older people can’t just take theirs off 😉

@WomenBeingAwful The author of this doesn’t realise that he doesn’t care. Also there are women who absolutely are into it. So it’s an amazing automatic magnet for the right type of person that you wish to attract.