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I'm pleased to share our latest preprint: Combinatorial effects of gene dosage, polygenic background and environment on complex traits 🧵medrxiv.org/content/10.648…
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Jonathan Sebat
17K posts
Jonathan Sebat
@sebatlab
From DNA to the brain. Occasionaly fatherhood, cycling, indie rock. No, Dad will not turn his music down.
La Jolla, CA Katılım Ekim 2014
2.8K Takip Edilen5K Takipçiler
What were the odds on Polymarket that the Muppets would play 7 Nation Army in the #worldcup final?
GIF
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@SashaGusevPosts @NagpalSini This makes sense. We’ve looked extensively at rare variant x PGS interactions and they mostly too small to detect but other rare variant x context interactions are quite strong PMID: 42094142
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Thought-provoking paper on interactions between genetic risk and exposures/behaviors:
nature.com/articles/s4158…
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I have a zoom call at 12. France and Spain are going to have to reschedule
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I love the smell of rodents in the morning. It smells like victory.
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@JG_Underwood I’m in the pocket of big grocery. They pay me in ahi steaks and cilantro
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This year I fielded alot of questions on the causes of autism. It's good to see that some of it is cutting through the noise.
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This makes me proud to be an American 🫡
Butthole Surfers@buttholesurfers
July 4, 1989. National Mall, Washington DC. We have always celebrated this holiday correctly. Happy Fourth 🔥🇺🇸
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Jonathan Sebat retweetledi
The Tartan Army marching through South Beach. The World Cup this year has been the most cathartic single event in uniting the world.
I get it. It’s soccer. But you don’t really have to appreciate the sport to appreciate the impact. Our nation is healing and other countries are helping. I love it. ❤️🇺🇸🏴🔥
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@JamesFasham Liseberg was the first place I took my son on a roller coaster and he was hooked instantly. Not sure why, but I have such fond my memories of that one day. The whole trip to Sweden was bliss
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I'm preparing a new talk. Here's one slide that I'm particularly proud of
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@sebatlab I only care about the 5% replication rate, thats perfect
👌
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Jonathan Sebat retweetledi
New [Souaiaia et al. 2026 Nature] paper argues that there is "distinct genetic architecture in the tails of complex traits". Some of my thoughts:
I'm not a fan of framing traits as having distinct architectures at the extremes when it's not really what's going on
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@effatma I prefer to be addressed based on my FTP. Jonathan Sebat 3.9 watts/kg
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@sebatlab and this is coming from someone who says "please call me Mike" to trainees and has to actively inhibit adding "Dr. Taffe is my dad" to it. but I learned about other people along the way.
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B.S. MDs are the only people I know who are addressed as “doctor” by their co-workers. I know very few academic scientists who refer to themselves or their colleagues by their credentials. “Dr.” is used mainly as formal way of addressing someone who you have just met.
Dr. Priyam Bordoloi@DocPriyamMD
Medical Doctors: Hey, I'm the cardiologist keeping you alive, just call me Alex. PhDs: Please refer to me as Dr. Monica, I did my thesis on ancient pottery. Look, I know the word 'Doctor' comes from the Latin docere (to teach). I know academics had the title first and I have full respect for the grind. But why are they always the ones defending the title like their lives depend on it? If someone screams "Is there a doctor on the plane?!" absolutely nobody is looking for a Doctor of Philosophy
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Jonathan Sebat retweetledi
1/ We conclude this Twitter takeover spotlighting an upcoming symposium at #WCPG2026
“Advancing Psychiatric Genomics through Large-Scale African Cohorts” 🌍🧬
The session will highlight how African cohorts are reshaping psychiatric genetics globally
@MLCampbell @rockyestroud2
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