Saif Khan

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Saif Khan

Saif Khan

@sfk_usc

Graduate student at @USC

Katılım Kasım 2019
202 Takip Edilen122 Takipçiler
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Saif Khan
Saif Khan@sfk_usc·
A part of my PhD work is now out in @Nature. We address one of the biggest open questions in GPCR biology — the structural basis of ligand efficacy. Using naloxone (Narcan) and loperamide, we capture GDP-bound MOR–Gi intermediates, visualize nucleotide release, and derive a comprehensive model of how these drugs modulate signaling: 🔗 nature.com/articles/s4158…
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Cornelius Gati
Cornelius Gati@CorneliusGati·
Fantastic news: our very own graduate student Aaliyah Tyson has been awarded a prestigious R36 NIDA Substance Use/Substance Use Disorder Dissertation Research Award. Many congratulations to this very well deserved recognition! @803Ast @NIDAnews
Cornelius Gati tweet mediaCornelius Gati tweet media
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Brady Johnston
Brady Johnston@bradyajohnston·
If there is big biotech announcement happening, #MolecularNodes is being used for it. I only had the realisation in the past day, but it's strange to have my software very quickly become the visual face for $100M announcements and massive scientific breakthroughs.
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Astrobiology
Astrobiology@astrobiology·
Interesting how two similar tweets - different scales - disciplines - appear in sequence on a social media. Look at the video in the left post x.com/CorneliusGati/… Molecular machines moving on a backbone similar to the Mobile Servicing System movement on @Space_station #nanotechnology #genomics #astrobiology @CorneliusGati @NASAScience
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Cornelius Gati@CorneliusGati

Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 nature.com/articles/s4158…

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Saif Khan
Saif Khan@sfk_usc·
A part of my PhD work is now out in @Nature. We address one of the biggest open questions in GPCR biology — the structural basis of ligand efficacy. Using naloxone (Narcan) and loperamide, we capture GDP-bound MOR–Gi intermediates, visualize nucleotide release, and derive a comprehensive model of how these drugs modulate signaling: 🔗 nature.com/articles/s4158…
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Saif Khan retweetledi
Shota Suzuki
Shota Suzuki@structure_bio36·
お、聞いていたやつだ。 ””Structural snapshots capture nucleotide release at the μ-opioid receptor” nature.com/articles/s4158…
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Cornelius Gati
Cornelius Gati@CorneliusGati·
Supported by extensive molecular dynamics simulations, we assembled the first half of the G protein activation pathway — a major step toward understanding how GPCRs translate drug binding into cellular signaling. (7/n)
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Cornelius Gati
Cornelius Gati@CorneliusGati·
The mind-blowing part: a “latent” state — where the receptor and G protein both appear inactive, yet remain bound to each other. Naloxone traps this state, stalling activation. This likely explains its ability to block opioid signaling so effectively. (6/n)
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Mukshud
Mukshud@Mukshud·
i love these animations. Reminds me of the seminal DE Shaw MD simulations showing how a ligand traverses the binding surfaces of protein kinases to find the binding pocket
Saif Khan@sfk_usc

A part of my PhD work is now out in @Nature. We address one of the biggest open questions in GPCR biology — the structural basis of ligand efficacy. Using naloxone (Narcan) and loperamide, we capture GDP-bound MOR–Gi intermediates, visualize nucleotide release, and derive a comprehensive model of how these drugs modulate signaling: 🔗 nature.com/articles/s4158…

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Cornelius Gati
Cornelius Gati@CorneliusGati·
Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 nature.com/articles/s4158…
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Saif Khan
Saif Khan@sfk_usc·
You can read all this and more in our paper that is out now in @Nature. I am deeply grateful to all those who have helped bring this work to life. First and foremost, my PhD advisor, the incredible @CorneliusGati, who makes it all possible. All our incredible co-authors. Gye Won Han for helping me survive new states, new maps and new models, on the daily! And a most special thanks to blender-sensei Vishwang (WANG-3D) for helping me create some stunning 3D art-work!
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Saif Khan
Saif Khan@sfk_usc·
The awesome Mohsen Ranjbar performed Molecular dynamics on these states, which tracked perfectly with the model we derived from experimental structures – GDP release follows a progressive loss of affinity driven by ligand-induced allosteric transitions across MOR–Gi. Efficacious ligands (e.g. loperamide) promote these transitions, while weaker ones (e.g. naloxone) stall them, precluding GDP release and Gi activation. Thus, addressing decades of debate on the structural and functional mechanisms of GDP in G-protein signaling.
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Keşfet

@803Ast @NIDAnews @Nature @USCDornsife @Space_station @CorneliusGati @NASAScience @elonmusk