Shelly Sharma

🚨 #ISC26 delivered BIG for stroke care. Multiple practice-important and promising trials across thrombosis, reperfusion, EVT, ICH, and neuroprotection 🏥🧠👇 🔹 OCEANIC-STROKE – Positive phase III: FXIa inhibition with asundexian reduced ischemic stroke in patients with non-cardioembolic stroke or high-risk TIA on antiplatelet therapy without increased major bleeding 🔹 OPTION – In patients with salvageable tissue, tenecteplase (4.5–24h) significantly improved 90-day excellent outcomes with higher sICH (2.8% vs 0%) 🔹 CHOICE-2 – Largest phase III trial of IA alteplase after successful EVT: higher excellent outcomes (mRS 0–1), no increase in sICH, NNT ≈ 7 🔹 FASTEST – rFVIIa for spontaneous ICH: promising early results in spot sign–positive patients treated <90 min 🔹 LAIS – Loberamisal (dual-target neuroprotection) within 48h for AIS (NIHSS 7–20): 13% absolute increase in excellent functional outcomes at 90 days 🔹 DISTALS – Tigertriever for distal occlusions: higher successful reperfusion at 24h without increased sICH 🔹 ORIENTA-MeVO – EVT for MeVO improved 90-day functional outcomes without excess sICH in a Chinese population The stroke playbook is evolving in real time. 🔥 #Stroke #ISC26 #VascularNeurology #EVT #Tenecteplase #ICH #ClinicalTrials #AHAScience #StrokeResearch @StrokeAHA_ASA @AHAScience 🧠

Here is an app that I’ve created for cognitive testing. It’s freely available and collates most of the commonly used bedside tests in Neurology/Neurosurgery. Let me know if anyone has any suggestions, recommendations or questions! mindmap-lobes-app.lovable.app

Watch. To. The. End. #SVIN2025 just casually dropped a bombshell: CREST-2 says carotid stenting > CEA + medical management. Yes, you read that right. The data has spoken: ARD 3.2%, RR 2.13, and the p-value didn’t come to play. The plenary hall was purely electric. You could feel the field shift in real time.

YES MIKIE SHERRILL & NEW JERSEY!!!! So proud of my fave state for recognizing strong leadership and someone who will stand up for ALL people #Election2025

Continuing the tradition of Taylor Swift inspired birthday cakes! Here’s to 31! 💙🧡

Spreading the gospel of ~ time is brain~ not only during the last week of nights but at @cyclebar ! Glad I made all my post night float AM rides & survived residency night float 🙌🏽 #neurology 🧠

~to live for the hope of it all~ Happy August!

🚨1/8 Excited to share the final version of our #meningioma #mesothelin #CART-cell paper, now published @NeuroOnc with corrected proofs! This preclinical work lays the foundation for applying CAR T-cell therapy to aggressive and treatment-refractory meningiomas. Highlights ⬇️

Our first-ever issue of Continuum dedicated to disorders of CSF dynamics is online and shipping! Why did we decide to dedicate a full issue to these disorders? 1/ 🌊🌊🌊

Happy Thrombectomy Day! @svinsociety @AshuPJadhav @AlexandraCzap @almuftifawaz @DanHarrisonMD @caseyalbin @rkchoi @DiogoHaussen @SitaraKoneru @SuspectedLVO @juneuromd @gdawod1 @AmeerEHassan @a_charidimou

GW Neurology takes on Medicine Society of DC awards reception! A fun time hearing from inspiring DC physicians

Community is being free to sing/scream Breakaway by Kelly Clarkson while climbing a hill without judgement

@mattadler81 More vegan breakfast sandwich options

What’s DC’s brunch scene missing?

Am I a DelCo dad right now ? 🦅

Manifesting these feels again #FlyEaglesFly

@mattadler81 Mita and Pow Pow are good options. Busboy and Poets are some solid picks on their menu. I feel like more DC places need to provide better brunch vegan options/ egg alternatives.

What’s the best vegan friendly restaurant in DC? Doesn’t need to be strictly vegan across the board just lots of vegan options.

Nothing beat surprising the family for Christmas 🎄 From our family to yours, Happy Holidays 💜

A friend of mine saw this math problem on Twitter & now we can’t find the original tweet. The problem is to solve for the shaded area. I believe I have an answer, but want to know what answers other folks get! #Mathematics #mathpuzzle #BrainTeaser #Nerds 🤓🤓 @Daily_Epsilon

I was not prepared & now I’m crying in the work room 😭😭 This tour and everything about it was so special