Sidi Chen

Excited to share our new Nature paper on in vivo CAR-NK CRISPRa screen + discovery of a hyperbooster for solid tumor nature.com/articles/s4158… Tx to Luojia, Paul, Drs Peng, Gunel, Moliterno, J Chen. #NK cell therapy @Yalegenetics @yalewestcampus @yalemed @yalecancer @yneurosurgery

Proud to share our new work at Nature biomedical engineering on mRNA vaccine platform innovation! nature.com/articles/s4155… @Carolina Lucas @zane_zhenhao Fang @Yale @YaleGenetics @YaleWestCampus

Proud to present our work at #KCRS25 on CAR-T screens, cell therapy and kidney cancer from @YaleMed @YaleGenetics @YaleWestCampus @YaleCancer Honored to be in session with Drs. Chuck Drake at JnJ, Nadal Rios at Hutch & Patrick Ott at Farber, hosted by David Braun &Hans Hammers.

#KCRS25 Session 6 highlighted how researchers are pushing the boundaries of what immunotherapy can do for kidney cancer patients. Engaging Native Immunity with ENPP3 with Chuck Drake TCR-Engineered Cell Therapy with @RosaNadalrios Next Generation T-Cell Engineering with @sidichen Future of Cancer Vaccines with Patrick Ott #AcceleratingCures

🎉 CRI is proud to announce the 2025 CLIP and Technology Impact Award projects, a new class of high‑potential studies and tools designed to push cancer immunotherapy further and faster! Explore: bit.ly/4lzfuZi #Immunotherapy #CancerResearch #CancerResearcher

Organizing an AI symposium on 6/20 with SAPA-CT at Yale. Please check it out and all are welcome to register/attend! @YaleWestCampus

Excited to present our new work on multiplex immune gene therapies for cancer @ASGCT 2025 @NOLA @YaleMed @YaleCancer @YaleGenetics @YaleWestCampus

.@sidichen co-chairs a symposium highlighting the transformative field of adoptive cell therapies for #cancer treatment #AACR25 with Dr. Daniel Powell @PennMedicine @AACR @SmilowCancer @YaleWestCampus @YaleGenetics

Our lab generated 4 new lines of Cas12a transgenic mice and demonstrated utility in immune engineering, tumor modeling, and genetic disease treatment. Around to share w the field & community! @YaleMed @YaleWest @YaleGenetics @YaleData Also @LabWinslow nature.com/articles/s4155…

Our new “MUCIG” therapy @FF Zhang ⁦@ScienceChow⁩ @GW ⁩ ⁦@YaleCancer⁩ ⁦@YaleGenetics⁩ ⁦@YaleWestCampus⁩ Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy | Nature Biotechnology nature.com/articles/s4158…

Our team’s new work “MUCIG” cancer therapy - Multi-target approach counters tumor growth in several cancers | Yale News @Feifei Zhang ⁦@ScienceChow⁩ @Guangchuan Wang ⁦@Yale⁩ ⁦@YaleCancer⁩ ⁦@YaleGenetics⁩ ⁦@YaleWestCampus⁩ news.yale.edu/2025/01/16/mul…

@jmuiuc @CarnegieMellon @SCSatCMU Great congrats! Exciting area and time!

Thrilled to launch the AI4BIO Center @CarnegieMellon! Our goal is to tackle grand challenges in understanding how cells work using AI/ML. Excited to help recruit faculty and foster collaboration across @SCSatCMU and campus. There is truly no place like CMU cs.cmu.edu/news/2024/ai4b…

@RongFan8 @MinaXu7 @Halene_lab @ZongmingMa @YaleCancer @YaleEngineering @YaleMed Congrats!

We are thrilled to receive the NCI Human Tumor Atlas Network (HTAN) center grant to map spatiotemporal dynamics of human lymphoma development, progression, transformation, and therapeutic response. 🤩🤩🤩 @MinaXu7 @Halene_lab @ZongmingMa @YaleCancer @YaleEngineering @YaleMed

@pdhsu Check out the origin of new genes

what were the very first genes? who were they? what did they do in this land before time?

Honored to serve on the panel of #AI for drug discovery in biomedicine at #AIME 2024 Utah. Very stimulating discussions on future of medicine, challenges etc, with experts and audience. @YaleData @yaledatascience @YaleGenetics @YaleCancer @Yale_Ventures

@pdhsu @Nature Very cool tech!

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

Our first in vivo primary NK screen that discovered new NK cellular checkpoints. Kudos for team for their 5 years of work. nature.com/articles/s4158… @YaleGenetics @YaleMed @YaleWestCampus @YaleCancer @YaleData

“Building a community and paying attention to that community is the essence of getting things done.” Today #JameelClinic Advisory Board Chair and Nobel laureate Phil Sharp celebrated the 50th anniversary of his lab, “The Sharpies” — half a century of sharp minds!

Our new high fidelity enhanced AsCas12a/Cpf1 transgenic mice after five years of work. Generated by Matt Dong and colleagues here in lab at @YaleGenetics @YaleCancer @YaleMed @YaleWestCampus Anyone who want to try them out feel free to please contact us. biorxiv.org/content/10.110…

Got the cover for this one as well at Nature Biomedical Engineering :)

Our new piece of tools for gene delivery and cell therapy.nature.com/articles/s4155… westcampus.yale.edu/news/yale-scie… @YaleGenetics @YaleMed @YaleWestCampus @YaleData @YaleCancer