Monte Winslow's Lab

.@EmilyAshkin et al @LabWinslow underscore important roles of STAG2 in suppressing lung tumorigenesis & highlight a STAG2-PAXIP1/PAGR1 tumor-suppressive program that may transcend cancer type. hubs.la/Q02-Y7_D0 @HaiqingXu3 @kinglhung @HowardYChang @Jesse_R_Dixon @ZXuSalk

Our latest preprint is online. Thanks to many in the lab for contributing to building these cell lines over the years including James’ and Alberto’s key contributions. biorxiv.org/content/10.110…

I'm thrilled to share our new study of the spatial evolution of Kras;p53-driven mouse lung adenocarcinoma! It's been fantastic leading this with @dianyang1117 & @sundakao, and enjoying a long-standing collaboration with @JswLab @YosefLab & @insitubiology. biorxiv.org/cgi/content/sh…

🚨🚨Now online @NatureCancer, my postdoc work in @SawyersLabMSKCC with @dana_peer 🚨🚨 we establish a powerful organoid transplantation model of prostate cancer neuroendocrine transformation. Open access for all! @HHMINEWS nature.com/articles/s4301… A 🧵... /1

Congratulations @dianyang1117 who did his PhD with @SageJulien and I some time ago… @stanfordcbio. Looking forward to some innovative things from him!

So excited to welcome the new @stanfordcbio students in the annual labcoat ceremony!

Newest preprint from @EmilyAshkin in our lab! Critical roles of a STAG2 cohesin-PAXIP1/PAGR1 tumor-suppressive axis in lung cancer in vivo. Might transcend cancer type. Amazing collaboration with @ZXuSalk @Jesse_R_Dixon @HaiqingXu3@PetrovADmitri biorxiv.org/content/10.110…

Excited to be part of this study by @TonyBoutelle @AttardiLaura on the key effectors of p53 in cancer. We love quantifying gene effects in tumors in vivo. p53->Zmat3 is an important axis during lung tumor initiation @HaiqingXu3 @PetrovADmitri biorxiv.org/content/10.110…

Looking for help with grad school applications? Apply to the Stanford Cancer Biology PhD Preview Program for 1-1 mentoring and student-led workshops!!! More details at med.stanford.edu/cancerbiology/… Apply: bit.ly/CBioPreview

Amazing collaboration between @EmilyShuldiner and @Alberto_DiazJ using somatic genome editing to model 60 different genotypes of EML4-ALK lung cancer. Genetics say that Variant 1 and Variant 3 should be considered distinct oncogenes @SotilloLab biorxiv.org/content/10.110…

Epigenetic dysregulation is widespread in cancer. Using a new in vivo method, we generated a phenotypic roadmap of 250 epigenetic regulators in lung tumorigenesis in vivo. Most critical epigenetic tumor suppressors including one I hadn’t heard of before. biorxiv.org/content/10.110…

SCI member @LabWinslow explores key variables in designing assays for studying #metastasis, preclinical models, and potential anti-metastatic therapies. bit.ly/3K3EJ5y

NEW content online! Dissecting metastasis using preclinical models and methods dlvr.it/SnStjX

NEW review out today published with @SpringerNature in @NatureRevCancer by our very own Jess Hebert @AmericanCancer !! rdcu.be/dbfSR #Metastasis #MouseModels #Methods

It is always exciting to be reminded that people in lab are not only great scientists but also talented pumpkin carvers!

Had a fantastic time learning about ongoing research in #pancreaticcancer at the Pancreas Cancer Research Symposium at @Stanford. Was amazing to catch up with Sohinee from @MaraShermanLab and @hanson_kathrynj from the Attardi lab!!

Fantastic meeting at #cshlcancer22 ! Great to spend time with the very first Winslow lab grad student @drmcaswell and the most recent @EmilyAshkin ! Many generations of science!!

Oncogene-negative lung adenocarcinomas afflict as many patients as those driven by either oncogenic KRAS or EGFR. Our paper in @CR_AACR uncovers biochemical drivers and therapeutic liabilities of these cancers. Great collaboration with @PetrovADmitri lab! doi.org/10.1158/0008-5…

Congratulation to our amazing postdoc Rui Tang (@Ruitang16) for receiving an NCI K99/R00 grant to dissect the reciprocal interactions between cancer cells and endothelial cells during metastasis!

@drmcaswell Amazing to see you two together! Wish I was there.