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378 posts

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@sigmaphemoid

Katılım Mart 2020
48 Takip Edilen12 Takipçiler
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www@sigmaphemoid·
@endotheremin @fredsoda @ricardoalatorre do u ever feel like ur ideology fails to explain the many happily partnered people you come across in real life through family or work or whatever
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@trrrincakes @juliette_hiyb @SkinnyTuna 2/2) the easiest way of explaining why the substack post doesn’t accomplish that would be to paste/ss specific sections in papers but i’m not able to for some reason
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trin
trin@trrrincakes·
@sigmaphemoid @juliette_hiyb @SkinnyTuna oh so essentially your point is that it’s usually invalid to try and establish a causal relationship between a single biological factor and a clinical/behavioural outcome?
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Kyle Kringle
Kyle Kringle@SkinnyTuna·
wouldnt it be crazy if ADHD was just chronic poor sleep quality and we all caught it from being on the computer too much
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@trrrincakes @juliette_hiyb @SkinnyTuna 1/2) it depends on how isolated the factor is and on the reasoning used; better mechanistic reasoning takes into account complexity/compensation/heterogeneity, and treats mechanisms as hypothesis generation not evidence in itself
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@trrrincakes @juliette_hiyb @SkinnyTuna the substack post follows the pattern howick describes: partial mechanisms that ignore complexity, compensation, alternative explanations, and heterogeneity idk if you have journal access or not but i can share relevant studies
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@trrrincakes @juliette_hiyb @SkinnyTuna psychiatry is a particularly vulnerable culprit, and the framework hedged on neuroscience validating diagnostic constructs by discovering the neurobiological mechanisms responsible for mental disorders, but failed to do so in the vast majority of cases
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@m1garandgirl @rim_raff @WarpigsPod @GrantSlatton i don't think it's dogshit and i don't think you need to see 3 professionals for one thing in the us lol, i was just responding to the hypothetical zero-regulation state the other guy suggested
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Grant Slatton
Grant Slatton@GrantSlatton·
dentistry is like the one medical-adjacent profession where outright fraud is a common issue normal consumers have to watch out for why
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@soundcloud @SCsupport @SoundCloudDev AI slop is ruining your platform, please make it so: 1. Artists have to declare if something is AI-generated 2. Users can filter out AI content 3. Users can filter out/hide songs and artists
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@notcomplex_ important to note here that "musical ability" was operationalised as i) can you tell two rhythms apart ii) can you spot a wrong note in a melody, and iii) can you distinguish two similar pitches so the results are not super surprising
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Alex
Alex@notcomplex_·
It's important to practice the things you want to improve directly: A twin study found that practicing an instrument did not improve other musical talents; instead, it was those with greater talent who practiced more.
Alex tweet media
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malph0
malph0@malph0·
@Punished_Alien @SkinnyTuna Recent ADHD research/scholarly debate makes the directionality of causation fuzzier than you would think. Could be a two way street
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Strawman Arguments
Strawman Arguments@StrawmanArgs·
@SkinnyTuna Whaaat? You mean staring into a screen that gives you more stimulation in an hour than most humans traditionally got in a year might cause issues?
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@bomebebot @SkinnyTuna no it hasn't what are you talking about? why do you make things up?
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Andrew 🔻
Andrew 🔻@bomebebot·
@SkinnyTuna It's been pretty universally agreed by many specialized in ADHD that it is a sleep disorder and directly involves delays in our circadian rhythm. Me and all my peers with ADHD have had fucked up sleep schedules pretty much since middle school.
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@Coolzippity @cremieuxrecueil okay, so i’m right that you’re using “5k complaints” and “lobbying” as evidence for some conspiracy? 1. “legitimacy” is not the point, complaints are confounded by things like placebo, they are not and can not be a strong evidence point to begin with 2. not sufficient evidence
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Ippi
Ippi@Coolzippity·
@sigmaphemoid @cremieuxrecueil No you wrote those conclusions on my behalf. 1. 5000 complaints to the DEA must contain some bias, but the DEA was specific about which aspects of the complaints were legitimate. 2. Certainly there is lobbying, that should make you more suspicious of purity, not less.
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Crémieux
Crémieux@cremieuxrecueil·
When ADHD drugs were given out sparingly, they had bigger effects. Now that people with less severe symptoms are being given medication for ADHD, the benefits of ADHD medication look smaller. That's an implication of diagnostic drift!
Crémieux tweet media
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@Coolzippity @cremieuxrecueil so your conclusion is that 1. the 5,000 complaints about medication efficacy were not confounded (tolerance) and reflected a genuine manufacturing issue 2. manufacturers lobbying DEA to adjust quotas is evidence they ended up secretly selling weaker pills?
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Ippi
Ippi@Coolzippity·
@sigmaphemoid @cremieuxrecueil federalregister.gov/documents/2026… Received 5000 complaints. Raised the cap by ~4 million g due to projected cap being low. Acknowledged racemic imbalance between d & l. Say FDA should deal with it (which they won't). Maybe it is not an issue, I think it is worth considering though.
GIF
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Jacob
Jacob@SoilandStream·
@MasterTimBlais The orexin stuff looks really promising, I'm going to try the reta hopes that it helps, sounds like it might
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