David Stănete

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David Stănete

David Stănete

@stanete

tech and bjj

Katılım Aralık 2009
77 Takip Edilen4.1K Takipçiler
David Stănete
David Stănete@stanete·
@tunguz The Spanish way is to nap under an olive tree! That’s the way I do it
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Bojan Tunguz
Bojan Tunguz@tunguz·
Having a super comfy day bed in your home office is one of the best things you can do for your brain.
Massimo@Rainmaker1973

Skip your daily nap, shrink your brain. A study by researchers from University College London and the University of the Republic in Uruguay has found that people who habitually take daytime naps tend to have significantly larger total brain volume—a key indicator of brain health that typically declines with age and is associated with reduced dementia risk. The team used Mendelian randomization, a method that leverages genetic variants (present from birth) that make people more likely to nap regularly. By analyzing brain MRI scans and health records from more than 35,000 participants in the UK Biobank, they discovered that those genetically inclined to nap had brain volumes corresponding to 2.6 to 6.5 fewer years of aging. While this doesn’t definitively prove that napping itself enlarges the brain, the genetic approach helps rule out many lifestyle-related confounding factors, providing stronger evidence of a potential causal relationship than traditional observational studies. Notably, the researchers found no link between napping predisposition and performance on tests of reaction time, memory, or visual processing. However, previous studies have shown that short naps can deliver immediate cognitive benefits. The study lacked specific data on nap duration, but prior research suggests naps of 30 minutes or less provide the greatest advantages while minimizing disruption to nighttime sleep. This is the largest study to date linking regular napping with brain structure. Although further research is needed in more diverse populations, the findings bolster the idea that a brief daytime rest may help preserve brain volume and support long-term cognitive health.

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Polymarket
Polymarket@Polymarket·
JUST IN: Cuba's electrical grid collapses for the 2nd time this past week.
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Bojan Tunguz
Bojan Tunguz@tunguz·
The old bad SWE productivity metric: lines of code written. The new bad SWE productivity metric: tokens consumed.
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NXT EU
NXT EU@NXT4EU·
India to use Euro alongside Dollar to trade internationally, reducing reliance on the USA. Part of the EU-India trade deal, Europe is expanding the role of the Euro worldwide, and building mutually beneficial partnerships across the globe!
NXT EU tweet media
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javi santana
javi santana@javisantana·
sometimes people, I mean, developers, don't know when to start moving data from postgres or the OLTP database of your choice into something like ClickHouse. Data size is usually one of the main drivers but it's not the only one, it's the combination of "data size" + "scan size" + "query frequency" If you you have 3Tb in postgres and you need to run a query a day that scans all of it, you may want to stay using just postgres If you have 5gb and scan it hundreds of time a minute, you may want to move the data out The pain of moving data is something developers minds cannot comprehend. Developers are capable of spending $500k year in salaries to save $750 a month in a bigger postgres instance.
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David Stănete
David Stănete@stanete·
@bryan_johnson Adopt, don’t buy. I love Spanish Galgos, they sleep most of the day except one hour per day where they need to exercise (just like you)
GIF
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Bryan Johnson
Bryan Johnson@bryan_johnson·
I'm thinking about getting two dogs. What breeds should I consider?
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Norn Group
Norn Group@NornGroup·
Very interesting and novel work. The insight is that ribosomes age, and as they do, they stall more during elongation, which shifts how efficiently specific classes of proteins get made. "Understanding aging biology" is central to our map of where progress on aging will come from because the clearer our picture of why cells deteriorate, the better our therapeutic hypotheses. What's notable here is that ribosome aging appears discrete and measurable, which raises the question: is it also targetable? We've funded work on the clearance side of proteostasis (@TheVilchezLab, link below), and this new preprint opens up the upstream end of that.
Jordy F. Botello@JordyBotello

Some molecular machines, like ribosomes, persist for long periods in cells Could molecular aging of ribosomes shape how proteins are made? In our preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) biorxiv.org/content/10.648…

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Polymarket
Polymarket@Polymarket·
JUST IN: Elon Musk proclaims "we are in the Singularity"
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Polymarket
Polymarket@Polymarket·
BREAKING: Amazon reportedly holds mandatory meeting after “vibe coded” changes trigger major outages.
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Ruxandra Teslo 🧬
Ruxandra Teslo 🧬@RuxandraTeslo·
Many problems in today's world are human/institution-shaped. That means they won't be changed by tech alone. One of them is clinical trials, a critical bottleneck to medical progress. Read my response to @DarioAmodei here: asimov.press/p/ai-clinical-…
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David Stănete
David Stănete@stanete·
When people say last but not least… it is usually the least
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Artemy Shumskiy
Artemy Shumskiy@ArtemyShumskiy·
The last few weeks genuinely feel like the Singularity is starting
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owl
owl@owl_posting·
Heuristics for lab robotics, and where its future may go (8.4k words, 38 minutes reading time) owlposting.com/p/heuristics-f… this is the longest article i have ever written. in it, i discuss the three ideologies of lab robotics progress, why they may all converge on the same business model, whether any of it will be actually helpful for the problems that plague drug discovery the most, and more this article involved discussions with sixteen people over the course of three weeks, and i am very grateful to them for answering the many questions i had about a field that i had long considered alien finally: this is a complicated field that is really still being birthed, so please let me know if i got anything wrong
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