Lorenz

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Lorenz

Lorenz

@studerl

Stem cell biologist @MSKCancerCenter studying human PSCs for modeling development & disease and for cell therapy. Opinions are my own and do not represent MSK.

New York, NY Katılım Mart 2009
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Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center@MSKCancerCenter·
Dr. @TabarViviane and Dr. @studerl, physician-scientists at MSK, have developed a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients. Early results show the treatment is safe and may improve Parkinson’s symptoms. "This is an important milestone on the road towards regenerative brain repair," says Dr. Tabar. "It represents more than two decades of collaborative work, based on very rigorous science beginning in our labs." Learn more: bit.ly/3EvfKbB bit.ly/4lxH2yC
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Faranak Fattahi
Faranak Fattahi@FaranakFattahi·
Thank you, Madhu! Grateful for the opportunity to visit you and your incredible colleagues at @MayoClinicGIHep. Truly inspired by the outstanding science and exciting discussions!
Madhusudan (Madhu) Grover M.D., AGAF@mgrover_gi

Had an awesome time hosting @FaranakFattahi for our motility visiting professorship. Phenomenal work on hPSC based models to interrogate ENS function and possible therapies. Very inspiring. Great company too! @MayoClinicGIHep @ANMSociety @esnm_eu @RomeFoundation @UCSF

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Lydia Finley
Lydia Finley@lydfinley·
Things I wish more people knew about doing science in the US (thread):
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Lorenz@studerl·
Congrats to @ZeltnerLab on their new paper. Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine science.org/doi/10.1126/sc…. It was exciting to see this story develop from way back.
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Lorenz
Lorenz@studerl·
Excited to see the work published @Nature. Excellent summary in thread below. Big collaborative effort with @ShenYingZhang1, @casanova_lab + many more. Special thanks to @yihaoo, @ZhiyongLiu7, Paul Bastard and in my lab @NoopurKhobrekar, Param Amin, @gabriele_ciceri & @harschnitz
Shen-Ying Zhang@ShenYingZhang1

1) Just out @Nature today! We show that human TMEFF1 is a restriction factor for #Herpes simplex virus 1(HSV1) in the brain, by limiting NECTIN1—HSV1-gD mediated HSV1 entry into cortical neurons. TMEFF1 defect can underlie HSV1 #encephalitis. nature.com/articles/s4158…

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Lorenz@studerl·
Excellent thread from @ShenYingZhang1 on this new collaborative story, and for our lab one of the first studies to test run new hindbrain neuron protocol developed by @harschnitz
Shen-Ying Zhang@ShenYingZhang1

(1) We are happy to share our new study, “SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency” @JExpMed! doi.org/10.1084/jem.20…. Accumulation of RNA lariats results in impaired antiviral immunity in hPSC-derived hindbrain neurons, underlying encephalitis. pic.twitter.com/UI6M7bwnxt

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Nathalie Saurat
Nathalie Saurat@NatSaurat·
Look, it’s the @studerl lab past and present at #ISSCR2024. Getting together is another awesome part of attending this conference 🤩
Nathalie Saurat tweet media
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Lorenz
Lorenz@studerl·
Super excited to see this study finally published after many years of work. Congrats to @NatSaurat for the heroic effort and to all the many amazing collaborators who made this work possible. Also big thanks to our funders particularly the JPB foundation, NIA and @ASAP_Research.
Lorenz@studerl

How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell bit.ly/3XBxCsA

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Lorenz@studerl·
How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell bit.ly/3XBxCsA
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Thomas Vierbuchen
Thomas Vierbuchen@TommyVierbuchen·
Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation. biorxiv.org/content/10.110…
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Lorenz
Lorenz@studerl·
Why do most dopamine neurons die shortly after transplantation and how can we fix it? Excited to see our story out at Cell. Congrats to @TaeWanKim0 & SoYeon Koo @MSKCancerCenter and to all the other collaborators who made this work possible. cell.com/cell/fulltext/…
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Keşfet

@TabarViviane @FaranakFattahi @MayoClinicGIHep @MSK_DeptOfMed @theNAMedicine @em6wong @DanielMedinaC12 @tarek10281